Zobrazeno 1 - 10
of 95
pro vyhledávání: '"J. Trammell"'
Publikováno v:
AGU Advances, Vol 4, Iss 6, Pp n/a-n/a (2023)
Abstract The interdependent crises of climate change and biodiversity losses require strategic policies to protect, manage, and restore essential ecosystems. Here, we evaluate the relative importance of US national forests (NFs) for protection and co
Externí odkaz:
https://doaj.org/article/14add81f14a74c87b53505a1916da265
Autor:
Bandar D. Alrehaili, Mikang Lee, Shogo Takahashi, Robert Novak, Bipin Rimal, Shannon Boehme, Samuel A. J. Trammell, Trisha J. Grevengoed, Devendra Kumar, Yazen Alnouti, Katya Chiti, Xinwen Wang, Andrew D. Patterson, John Y. L. Chiang, Frank J. Gonzalez, Yoon‐Kwang Lee
Publikováno v:
Hepatology Communications, Vol 6, Iss 10, Pp 2765-2780 (2022)
Abstract Bile acid‐CoA: amino acid N‐acyltransferase (BAAT) catalyzes bile acid conjugation, the last step in bile acid synthesis. BAAT gene mutation in humans results in hypercholanemia, growth retardation, and fat‐soluble vitamin insufficienc
Externí odkaz:
https://doaj.org/article/d79211ba0cd04455982000fdada5d57f
Autor:
A. Augusto Peluso, Agnete T. Lundgaard, Parizad Babaei, Felippe Mousovich-Neto, Andréa L. Rocha, Mads V. Damgaard, Emilie G. Bak, Thiyagarajan Gnanasekaran, Ole L. Dollerup, Samuel A. J. Trammell, Thomas S. Nielsen, Timo Kern, Caroline B. Abild, Karolina Sulek, Tao Ma, Zach Gerhart-Hines, Matthew P. Gillum, Manimozhiyan Arumugam, Cathrine Ørskov, Douglas McCloskey, Niels Jessen, Markus J. Herrgård, Marcelo A. S. Mori, Jonas T. Treebak
Publikováno v:
Peluso, A A, Lundgaard, A T, Babaei, P, Mousovich-Neto, F, Rocha, A L, Damgaard, M V, Bak, E G, Gnanasekaran, T, Dollerup, O L, Trammell, S A J, Nielsen, T S, Kern, T, Abild, C B, Sulek, K, Ma, T, Gerhart-Hines, Z, Gillum, M P, Arumugam, M, Ørskov, C, McCloskey, D, Jessen, N, Herrgård, M J, Mori, M A S & Treebak, J T 2023, ' Oral supplementation of nicotinamide riboside alters intestinal microbial composition in rats and mice, but not humans ', npj aging, vol. 9, 7 . https://doi.org/10.1038/s41514-023-00106-4
Peluso, A A, Lundgaard, A T, Babaei, P, Mousovich-Neto, F, Rocha, A L, Damgaard, M V, Bak, E G, Gnanasekaran, T, Dollerup, O L, Trammell, S A J, Nielsen, T S, Kern, T, Abild, C B, Sulek, K, Ma, T, Gerhart-Hines, Z, Gillum, M P, Arumugam, M, Ørskov, C, McCloskey, D, Jessen, N, Herrgård, M J, Mori, M A S & Treebak, J T 2023, ' Oral supplementation of nicotinamide riboside alters intestinal microbial composition in rats and mice, but not humans ', npj aging, vol. 9, no. 1, pp. 1-21 . https://doi.org/10.1038/s41514-023-00106-4
Peluso, A A, Lundgaard, A T, Babaei, P, Mousovich-Neto, F, Rocha, A L, Damgaard, M V, Bak, E G, Gnanasekaran, T, Dollerup, O L, Trammell, S A J, Nielsen, T S, Kern, T, Abild, C B, Sulek, K, Ma, T, Gerhart-Hines, Z, Gillum, M P, Arumugam, M, Ørskov, C, McCloskey, D, Jessen, N, Herrgård, M J, Mori, M A S & Treebak, J T 2023, ' Oral supplementation of nicotinamide riboside alters intestinal microbial composition in rats and mice, but not humans ', npj aging, vol. 9, no. 1, pp. 1-21 . https://doi.org/10.1038/s41514-023-00106-4
The gut microbiota impacts systemic levels of multiple metabolites including NAD+ precursors through diverse pathways. Nicotinamide riboside (NR) is an NAD+ precursor capable of regulating mammalian cellular metabolism. Some bacterial families expres
Autor:
Faisal Hayat, Manoj Sonavane, Mikhail V. Makarov, Samuel A. J. Trammell, Pamela McPherson, Natalie R. Gassman, Marie E. Migaud
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 3, p 1145 (2021)
As catabolites of nicotinamide possess physiological relevance, pyridones are often included in metabolomics measurements and associated with pathological outcomes in acute kidney injury (AKI). Pyridones are oxidation products of nicotinamide, its me
Externí odkaz:
https://doaj.org/article/d51e685506e24e0cbc927e332246a7ba
Autor:
Samuel A. J. Trammell, Mark S. Schmidt, Benjamin J. Weidemann, Philip Redpath, Frank Jaksch, Ryan W. Dellinger, Zhonggang Li, E. Dale Abel, Marie E. Migaud, Charles Brenner
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
NAD+ is an important coenzyme that mediates cellular metabolism and defends against stresses due to age and overnutrition. Here the authors demonstrate unique bioavailability of the NAD+ precursor vitamin nicotinamide riboside (NR) in mice and humans
Externí odkaz:
https://doaj.org/article/e34c321832984f148c714a8f86a0f42b
Autor:
Joanna Ratajczak, Magali Joffraud, Samuel A. J. Trammell, Rosa Ras, Núria Canela, Marie Boutant, Sameer S. Kulkarni, Marcelo Rodrigues, Philip Redpath, Marie E. Migaud, Johan Auwerx, Oscar Yanes, Charles Brenner, Carles Cantó
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Raising cellular levels of the metabolic cofactor NAD+ reverses key indicators of aging. Here, Ratajczak et al. show that cellular levels of NAD+ depend on the extracellular catalytic activity of NRK1, which processes two NAD+precursors, nicotinamide
Externí odkaz:
https://doaj.org/article/bed4a8bce0a947e6b296d8080b0074aa
Publikováno v:
Molecules, Vol 25, Iss 10, p 2371 (2020)
Farnesoid X receptor (FXR) and Takeda G-protein coupled receptor 5 (TGR5) are the two known bile acid (BA) sensitive receptors and are expressed in the intestine and liver as well as in extra-enterohepatic tissues. The physiological effects of extra-
Externí odkaz:
https://doaj.org/article/617308ddb86a41f78757a8e47bda6c0e
Autor:
Emilie Elmelund, Katrine Galsgaard, Christian D. Johansen, Samuel A. J. Trammell, Anna B. Bomholt, Marie Winther-Sørensen, Jenna E. Hunt, Charlotte M. Sørensen, Thomas Kruse, Jesper F. Lau, Trisha J. Grevengoed, Jens J. Holst, Nicolai Jacob Wewer Albrechtsen
Publikováno v:
SSRN Electronic Journal.
Autor:
Kaare V. Grunddal, Samuel A. J. Trammell, Cecilie Bæch-Laursen, Daniel B. Andersen, Stella F. S. Xu, Helle Andersen, Matthew P. Gillum, Seyed M. Ghiasi, Ivana Novak, Björn Tyrberg, Chien Li, Mette M. Rosenkilde, Bolette Hartmann, Jens J. Holst, Rune E. Kuhre
Publikováno v:
Grunddal, K V, Trammell, S A J, Bæch-Laursen, C, Andersen, D B, Xu, S F S, Andersen, H, Gillum, M P, Ghiasi, S M, Novak, I, Tyrberg, B, Li, C, Rosenkilde, M M, Hartmann, B, Holst, J J & Kuhre, R E 2022, ' Opposing roles of the entero-pancreatic hormone urocortin-3 in glucose metabolism in rats ', Diabetologia, vol. 65, no. 6, pp. 1018-1031 . https://doi.org/10.1007/s00125-022-05675-9
Grunddal, K V, Trammell, S A J, Bæch-Laursen, C, Andersen, D B, Xu, S F S, Andersen, H, Gillum, M P, Ghiasi, S M, Novak, I, Tyrberg, B, Li, C, Rosenkilde, M M, Hartmann, B, Holst, J J & Kuhre, R E 2022, ' Opposing roles of the entero-pancreatic hormone urocortin-3 in glucose metabolism in rats ', Diabetologia, vol. 65, pp. 1018–1031 . https://doi.org/10.1007/s00125-022-05675-9
Grunddal, K V, Trammell, S A J, Bæch-Laursen, C, Andersen, D B, Xu, S F S, Andersen, H, Gillum, M P, Ghiasi, S M, Novak, I, Tyrberg, B, Li, C, Rosenkilde, M M, Hartmann, B, Holst, J J & Kuhre, R E 2022, ' Opposing roles of the entero-pancreatic hormone urocortin-3 in glucose metabolism in rats ', Diabetologia, vol. 65, pp. 1018–1031 . https://doi.org/10.1007/s00125-022-05675-9
Aim/hypothesis Urocortin-3 (UCN3) is a glucoregulatory peptide produced in the gut and pancreatic islets. The aim of this study was to clarify the acute effects of UCN3 on glucose regulation following an oral glucose challenge and to investigate the
Autor:
Morten, Dall, Anna S, Hassing, Lili, Niu, Thomas S, Nielsen, Lars R, Ingerslev, Karolina, Sulek, Samuel A J, Trammell, Matthew P, Gillum, Romain, Barrès, Steen, Larsen, Steen S, Poulsen, Matthias, Mann, Cathrine, Ørskov, Jonas T, Treebak
Publikováno v:
The Journal of Biological Chemistry
Nicotinamide phosphoribosyltransferase (NAMPT) converts nicotinamide to NAD+. As low hepatic NAD+ levels have been linked to the development of nonalcoholic fatty liver disease, we hypothesized that ablation of hepatic Nampt would affect susceptibili