Zobrazeno 1 - 8
of 8
pro vyhledávání: '"J. Trae Hampton"'
Autor:
Peng-Hsun Chase Chen, Xuejiao Shirley Guo, Hanyuan Eric Zhang, Gopal K. Dubey, Zhi Zachary Geng, Carol A. Fierke, Shiqing Xu, J. Trae Hampton, Wenshe Ray Liu
Publikováno v:
ACS Central Science, Vol 10, Iss 4, Pp 782-792 (2024)
Externí odkaz:
https://doaj.org/article/d71941143edf450a9bfc51584dc72d67
Autor:
Jeffery M. Tharp, J. Trae Hampton, Catrina A. Reed, Andreas Ehnbom, Peng-Hsun Chase Chen, Jared S. Morse, Yadagirri Kurra, Lisa M. Pérez, Shiqing Xu, Wenshe Ray Liu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Most epigenetic regulator inhibitors target tunnels of active sites, rather than the peptide binding groove, leading to concerns with low selectivity. Here the authors use an amber obligate phage library to rapidly identify isoform-selective inhibito
Externí odkaz:
https://doaj.org/article/b1aac1c05c7c4fed851748bbcd7bc307
Autor:
J. Trae Hampton, Chia-Chuan Dean Cho, Zhi Zachary Geng, Demonta D. Coleman, Peng-Hsun Chase Chen, Gopal K. Dubey, Lauralee D. Sylvain, Shiqing Xu, Wenshe Ray Liu
In the past two decades, phage display has emerged as a powerful technique for the identification of antibodies and peptide ligands for therapeutic targets. Using the amber suppression-based noncanonical amino acid (ncAA) mutagenesis approach, we and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::692615a02308800f6244faf2e2def003
https://doi.org/10.1101/2022.12.19.521047
https://doi.org/10.1101/2022.12.19.521047
Autor:
J. Trae Hampton, Tyler J. Lalonde, Jeffery M. Tharp, Yadagiri Kurra, Yugendar R. Alugubelli, Christopher M. Roundy, Gabriel L. Hamer, Shiqing Xu, Wenshe Ray Liu
Publikováno v:
ACS chemical biology. 17(10)
Using the regioselective cyanobenzothiazole condensation reaction with an N-terminal cysteine and the chloroacetamide reaction with an internal cysteine, a phage-displayed macrocyclic 12-mer peptide library was constructed and subsequently validated.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b17c78a98ce80b5c2a0e788bd2637e83
https://pubmed.ncbi.nlm.nih.gov/36174018
https://pubmed.ncbi.nlm.nih.gov/36174018
Autor:
Jared S. Morse, Yan J. Sheng, J. Trae Hampton, Lauralee D. Sylvain, Sukant Das, Yugendar R. Alugubelli, Peng-Hsun Chase Chen, Kai S. Yang, Shiqing Xu, Carol A. Fierke, Wenshe Ray Liu
The phage-assisted, active site-directed ligand evolution (PADLE) is a recently developed technique that uses an amber codon-encoded noncanonical amino acid (ncAA) as an anchor to direct phage-displayed peptides to a target for an enhanced ligand ide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6bd525d84b0b2f9d07d7846bcd96523
https://doi.org/10.1101/2022.09.14.508049
https://doi.org/10.1101/2022.09.14.508049
Autor:
J. Trae Hampton, Tyler J. Lalonde, Jeffery M. Tharp, Yadagiri Kurra, Yugendar R. Alugubelli, Christopher M. Roundy, Gabriel L. Hamer, Shiqing Xu, Wenshe Ray Liu
Using the regioselective cyanobenzothiazole condensation reaction with the N-terminal cysteine and the chloroacetamide reaction with an internal cysteine, a phage-displayed macrocyclic 12-mer peptide library was constructed and subsequently validated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ff854f1e0ff7c13bc50cdb41309f0d2
https://doi.org/10.1101/2022.07.06.498864
https://doi.org/10.1101/2022.07.06.498864
Autor:
J. Trae Hampton, Duen Shian Wang, Jin Liu, Wenshe R. Liu, Sukant K. Das, Jeffery M. Tharp, Xiaoshan Shayna Wang, Catrina A. Reed, Peng Hsun Chase Chen, Yang Shen, Hamed S. Hayatshahi
Publikováno v:
Angew Chem Int Ed Engl
Superior to linear peptides in biological activities, cyclic peptides are considered to have great potentials used as therapeutic agents. In order to identify cyclic peptide ligands for therapeutic targets, selection from phage-displayed peptide libr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afb35f4a61f551d4af12876361d84689
https://doi.org/10.1002/anie.201908713
https://doi.org/10.1002/anie.201908713
Autor:
Catrina A. Reed, Peng-Hsun Chase Chen, Jared S. Morse, Jeffery M. Tharp, J. Trae Hampton, Andreas Ehnbom, Yadagirri Kurra, Wenshe R. Liu, Shiqing Xu, Lisa M. Pérez
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
Although noncanonical amino acids (ncAAs) were first incorporated into phage libraries through amber suppression nearly two decades ago, their application for use in drug discovery has been limited due to inherent library bias towards sense-containin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef5ded75688845688a26eda79e158570
https://doi.org/10.1038/s41467-020-15057-7
https://doi.org/10.1038/s41467-020-15057-7