Zobrazeno 1 - 10
of 6 482
pro vyhledávání: '"J. Timothy"'
Autor:
Filippo Pullara, Madison C. Forsmann, Ignacio J. General, Joseph C. Ayoob, Emily Furbee, Sandra L. Castro, Xiaoping Hu, J. Timothy Greenamyre, Roberto Di Maio
Publikováno v:
Redox Biology, Vol 75, Iss , Pp 103254- (2024)
Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα) signaling in the brain plays a critical role in regulating neuronal Ca2+ homeostasis. Its dysfunctional activity is associated with various neurological and neurodegenerative disorders, includ
Externí odkaz:
https://doaj.org/article/b3192ef9b1694825bce7a14bb59f7c08
Autor:
Dito Anurogo, Chia-Yuan Chen, Chu-Chi Lin, Jeanne Adiwinata Pawitan, Daniel W. Qiu, J. Timothy Qiu
Publikováno v:
Journal of Immunotoxicology, Vol 21, Iss 1 (2024)
Infections caused by the influenza virus lead to both epidemic and pandemic outbreaks in humans and animals. Owing to their rapid production, safety, and stability, DNA vaccines represent a promising avenue for eliciting immunity and thwarting viral
Externí odkaz:
https://doaj.org/article/d02dd6f30363438db5dbe6495b524511
Autor:
Neda M. Ilieva, Eric K. Hoffman, Mohammed A. Ghalib, J. Timothy Greenamyre, Briana R. De Miranda
Publikováno v:
Neurobiology of Disease, Vol 196, Iss , Pp 106522- (2024)
Idiopathic Parkinson's disease (PD) is epidemiologically linked with exposure to toxicants such as pesticides and solvents, which comprise a wide array of chemicals that pollute our environment. While most are structurally distinct, a common cellular
Externí odkaz:
https://doaj.org/article/a92ed5ed1b54404a8a38e89a2172c19a
Autor:
Amber D. Van Laar, Katherine R. Webb, Matthew T. Keeney, Victor S. Van Laar, Alevtina Zharikov, Edward A. Burton, Teresa G. Hastings, Kelly E. Glajch, Warren D. Hirst, J. Timothy Greenamyre, Emily M. Rocha
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-9 (2023)
Abstract Individuals with Parkinson’s disease (PD) typically receive a diagnosis once they have developed motor symptoms, at which point there is already significant loss of substantia nigra dopamine neurons, α-synuclein accumulation in surviving
Externí odkaz:
https://doaj.org/article/3bb4b73d2d3c4865a71165a73daefadb
Autor:
J. Huybregts, S. Polak, W. Jacobs, M. Arts, B. Meyer, M. Wostrack, V. ButenschÖN, M. Osti, C. Oner, W.B. Slooff, R. Feller, G.J. Bouma, S. Harhangi, B. Depreitere, Ø. Nygaard, C. Weber, K. MÜLler, J. Timothy, F. Pellise, M.M. Rasmussen, E.V. Zwet, E. Steyerberg, W. Peul, C. Vleggeert-Lankamp
Publikováno v:
Brain and Spine, Vol 4, Iss , Pp 103207- (2024)
Externí odkaz:
https://doaj.org/article/e8c774f2c60a4211aab8bf90cdfb0ffc
Autor:
Roberto Di Maio, Matthew T. Keeney, Veronika Cechova, Amanda Mortimer, Ahssan Sekandari, Pascal Rowart, J. Timothy Greenamyre, Bruce A. Freeman, Marco Fazzari
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-11 (2023)
Abstract To date there are no therapeutic strategies that limit the progression of Parkinson’s disease (PD). The mechanisms underlying PD-related nigrostriatal neurodegeneration remain incompletely understood, with multiple factors modulating the c
Externí odkaz:
https://doaj.org/article/5eee1875d5414f4f93c5537ba12898e0
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Height-induced postural threat affects emotional state and standing balance behaviour during static, voluntary, and dynamic tasks. Facing a threat to balance also affects sensory and cortical processes during balance tasks. As sensory and cognitive f
Externí odkaz:
https://doaj.org/article/172dcc2ff8f04e7e86870f04b62eeab9
Autor:
Tiffany Shi, Ashley R. Burg, J. Timothy Caldwell, Krishna M. Roskin, Cyd M. Castro-Rojas, P. Chukwunalu Chukwuma, George I. Gray, Sara G. Foote, Jesus A. Alonso, Carla M. Cuda, David A. Allman, James S. Rush, Catherine H. Regnier, Grazyna Wieczorek, Rita R. Alloway, Adele R. Shields, Brian M. Baker, E. Steve Woodle, David A. Hildeman
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 14 (2023)
Bulk analysis of renal allograft biopsies (rBx) identified RNA transcripts associated with acute cellular rejection (ACR); however, these lacked cellular context critical to mechanistic understanding of how rejection occurs despite immunosuppression
Externí odkaz:
https://doaj.org/article/42e02f11da09405283e3b6ddcd572117
Autor:
Matthew T. Keeney, Eric K. Hoffman, Kyle Farmer, Christopher R. Bodle, Marco Fazzari, Alevtina Zharikov, Sandra L. Castro, Xiaoping Hu, Amanda Mortimer, Julia K. Kofler, Eugenia Cifuentes-Pagano, Patrick J. Pagano, Edward A. Burton, Teresa G. Hastings, J. Timothy Greenamyre, Roberto Di Maio
Publikováno v:
Neurobiology of Disease, Vol 170, Iss , Pp 105754- (2022)
Mitochondrial dysfunction and oxidative stress are strongly implicated in Parkinson's disease (PD) pathogenesis and there is evidence that mitochondrially-generated superoxide can activate NADPH oxidase 2 (NOX2). Although NOX2 has been examined in th
Externí odkaz:
https://doaj.org/article/95c583e7c1c84f7fafa51c450059efc9
Autor:
Liyang Ji, Prabuddha Waduge, Yan Wu, Chengchi Huang, Avinash Kaur, Paola Oliveira, Hong Tian, Jinsong Zhang, J. Timothy Stout, Christina Y. Weng, Keith A. Webster, Wei Li
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 10531 (2023)
Diabetic retinopathy (DR), a leading cause of vision loss in working-age adults, induces mosaic patterns of vasculopathy that may be associated with spatial heterogeneity of intraretinal endothelial cells. We recently reported that secretogranin III
Externí odkaz:
https://doaj.org/article/0be05a1266c142fb8281a28fb0582ab3