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Akademický článek

Lipoprotein[a] in the chimpanezee: relationship of apo[a] phenotype to elevated plasma Lp[a] levels.

Autor: C Doucet, T Huby, J Chapman, J Thillet

Publikováno v: Journal of Lipid Research, Vol 35, Iss 2, Pp 263-270 (1994)

Several studies have documented the presence of Lp[a] in nonhuman primates. However, data are lacking in great apes such as the chimpanzee. We have studied the quantitative distribution of Lp[a], as well as the frequency of apo[a] phenotypes, in a po

Externí odkaz: https://doaj.org/article/8caed0a2e5654363938ecefe042f1b8d

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Genetic polymorphisms of the gene for apolipoprotein(a) and their association with lipoprotein(a) levels and myocardial infarction

Autor: J. Thillet

Publikováno v: Biochemical Society Transactions. 27:463-466

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8837fb8837f8ab758be871f662cae6ed
https://doi.org/10.1042/bst0270463

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Lipoprotein(a) Is a Potent Chemoattractant for Human Peripheral Monocytes

Autor: M.J. Chapman, J Thillet, Thomas Simmet, Tatjana Syrovets

Publikováno v: Blood. 90:2027-2036

We have previously reported that the serine protease plasmin triggers chemotaxis in human peripheral monocytes, but not in polymorphonuclear leukocyte. We now show that the structurally related lipoprotein(a) (Lp[a]) as well as recombinant apolipopro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d20ff832db6e4d6168135759752bcfb2
https://doi.org/10.1182/blood.v90.5.2027

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Functional analysis of the chimpanzee and human apo(a) promoter sequences: identification of sequence variations responsible for elevated transcriptional activity in chimpanzee

Autor: T, Huby, C, Dachet, R M, Lawn, J, Wickings, M J, Chapman, J, Thillet

Publikováno v: The Journal of biological chemistry. 276(25)

Lp(a) concentrations vary considerably among individuals and are primarily determined by the apo(a) gene locus. We have previously shown that mean plasma Lp(a) levels in the chimpanzee are significantly higher than those observed in humans (Doucet, C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::699def7584d066dc34a2c9f746c0e836
https://pubmed.ncbi.nlm.nih.gov/11301336

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Structural elucidation of the N- and O-glycans of human apolipoprotein(a): role of o-glycans in conferring protease resistance

Autor: B, Garner, A H, Merry, L, Royle, D J, Harvey, P M, Rudd, J, Thillet

Publikováno v: The Journal of biological chemistry. 276(25)

Apolipoprotein(a) (apo(a)) is a multikringle domain glycoprotein that exists covalently linked to apolipoprotein B100 of low density lipoprotein, to form the lipoprotein(a) (Lp(a)) particle, or as proteolytic fragments. Elevated plasma concentrations

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d96c888d0e4ab1fc348374fc8caab1a5
https://pubmed.ncbi.nlm.nih.gov/11294842

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Elevated lipoprotein(a) levels and small apo(a) isoforms are compatible with longevity: evidence from a large population of French centenarians

Autor: J, Thillet, C, Doucet, J, Chapman, B, Herbeth, D, Cohen, L, Faure-Delanef

Publikováno v: Atherosclerosis. 136(2)

Epidemiological studies have shown lipoprotein(a) (Lp(a)) to be an independent risk factor for cardiovascular disease. Lp(a) is a cholesterol-rich, low-density lipoprotein (LDL)-like particle to which a large glycoprotein, apolipoprotein(a) (apo(a))

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ad6f67f7e19565698554bc7d98153d3b
https://pubmed.ncbi.nlm.nih.gov/9543111

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Lipoprotein(a) is a potent chemoattractant for human peripheral monocytes

Autor: T, Syrovets, J, Thillet, M J, Chapman, T, Simmet

Publikováno v: Blood. 90(5)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::be4d3a059f84bbfc5d40b83758af80a4
https://pubmed.ncbi.nlm.nih.gov/9292539

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Trimethoprim binds in a bacterial mode to the wild-type and E30D mutant of mouse dihydrofolate reductase

Autor: C R, Groom, J, Thillet, A C, North, R, Pictet, A J, Geddes

Publikováno v: The Journal of biological chemistry. 266(30)

Previous crystallographic studies of the antibacterial trimethoprim in complexes with bacterial and avian dihydrofolate reductases have shown substantial differences in the mode of binding, providing plausible explanations for the origin of the remar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::faa12228c366181932615fa2c0cde723
https://pubmed.ncbi.nlm.nih.gov/1939053

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