Zobrazeno 1 - 10
of 2 558
pro vyhledávání: '"J. Thiele"'
Autor:
Deblina Banerjee, Sukriti Bagchi, Zhihui Liu, Hsien-Chao Chou, Man Xu, Ming Sun, Sara Aloisi, Zalman Vaksman, Sharon J. Diskin, Mark Zimmerman, Javed Khan, Berkley Gryder, Carol J. Thiele
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Temporal regulation of super-enhancer (SE) driven transcription factors (TFs) underlies normal developmental programs. Neuroblastoma (NB) arises from an inability of sympathoadrenal progenitors to exit a self-renewal program and terminally d
Externí odkaz:
https://doaj.org/article/e046b0fa15084801bf258b679fd00713
Publikováno v:
Malaria Journal, Vol 23, Iss 1, Pp 1-15 (2024)
Abstract The use of fluorescent proteins (FPs) in Plasmodium parasites has been key to understand the biology of this obligate intracellular protozoon. FPs like the green fluorescent protein (GFP) enabled to explore protein localization, promoter act
Externí odkaz:
https://doaj.org/article/b2b359d88d3342089b6ac1f234c2793f
Autor:
Qi Li, Yexi Chen, Yang Chen, Zhongyan Hua, Baocheng Gong, Zhihui Liu, Carol J. Thiele, Zhijie Li
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 174, Iss , Pp 116562- (2024)
Rhabdomyosarcoma (RMS), a mesenchymal tumor occurring in the soft tissue of children, is associated with a defect in differentiation. This study unveils a novel anti-tumor mechanism of dimethylaminomicheliolide (DMAMCL), which is a water-soluble deri
Externí odkaz:
https://doaj.org/article/87dca72106b843bcb8e24ef28cd7257d
Autor:
Zhihui Liu, Xiyuan Zhang, Man Xu, Jason J Hong, Amanda Ciardiello, Haiyan Lei, Jack F Shern, Carol J Thiele
Publikováno v:
PLoS Biology, Vol 22, Iss 3, p e3002240 (2024)
MYCN activates canonical MYC targets involved in ribosome biogenesis, protein synthesis, and represses neuronal differentiation genes to drive oncogenesis in neuroblastoma (NB). How MYCN orchestrates global gene expression remains incompletely unders
Externí odkaz:
https://doaj.org/article/c1ec3c76324c4ee8b3762bb57f013072
Autor:
Stacey Stauffer, Jacob S. Roth, Edjay R. Hernandez, Joshua T. Kowalczyk, Nancy E. Sealover, Katie E. Hebron, Amy James, Kristine A. Isanogle, Lisa A. Riffle, Lilia Ileva, Xiaoling Luo, Jin-Qiu Chen, Noemi Kedei, Robert L. Kortum, Haiyan Lei, Jack F. Shern, Joseph D. Kalen, Elijah F. Edmondson, Matthew D. Hall, Simone Difilippantonio, Carol J. Thiele, Marielle E. Yohe
Publikováno v:
Cancers, Vol 16, Iss 13, p 2320 (2024)
Activating mutations in the RAS/MAPK pathway are observed in relapsed neuroblastoma. Preclinical studies indicate that these tumors have an increased sensitivity to inhibitors of the RAS/MAPK pathway, such as MEK inhibitors. MEK inhibitors do not ind
Externí odkaz:
https://doaj.org/article/6aa231f7d2064697bf39a93b7ac6369e
Autor:
Christina J. Thiele, Laura J. Grange, Emily Haggett, Malcolm D. Hudson, Philippa Hudson, Andrea E. Russell, Lina M. Zapata-Restrepo
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 255, Iss , Pp 114782- (2023)
Microplastics are contaminants of emerging concern, not least due to their global presence in marine surface waters. Unsurprisingly, microplastics have been reported in salts harvested from numerous locations. We extracted microplastics from 13 Europ
Externí odkaz:
https://doaj.org/article/aebb5e2684db4bb18b207b3d6982f3e0
Autor:
Barbara Kunzler Souza, Natalia Hogetop Freire, Thiago Santos Monteiro, Alice Laschuk Herlinger, Mariane Jaeger, Matheus G. S. Dalmolin, Caroline Brunetto de Farias, Lauro Gregianin, André T. Brunetto, Algemir L. Brunetto, Carol J. Thiele, Rafael Roesler
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 20, p 15242 (2023)
Changes in epigenetic programming have been proposed as being key events in the initiation and progression of childhood cancers. HMT euchromatic histone lysine methyltransferase 2 (G9a, EHMT2), which is encoded by the G9a (Ehmt2) gene, as well as its
Externí odkaz:
https://doaj.org/article/01066e73efb24012a3a2e46f5e70e212
Autor:
Nan Li, Haiying Qin, Rosa Nguyen, Mitchell Ho, Ming Sun, Eytan Ruppin, Michael C Kelly, Yingying Cao, Reona Okada, Jeyshka M Reyes-González, Hannah G Stack, Charlie Seibert, Carol J Thiele
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 1 (2023)
Background Although most patients with newly diagnosed high-risk neuroblastoma (NB) achieve remission after initial therapy, more than 50% experience late relapses caused by minimal residual disease (MRD) and succumb to their cancer. Therapeutic stra
Externí odkaz:
https://doaj.org/article/c2a4dbca004d4ad9aeecc39207e2e0f9
Autor:
Corinna Probst, Sarela Garcia-Santamarina, Jacob T Brooks, Inge Van Der Kloet, Oliver Baars, Martina Ralle, Dennis J Thiele, J Andrew Alspaugh
Publikováno v:
PLoS Pathogens, Vol 18, Iss 6, p e1010195 (2022)
Copper homeostasis mechanisms are essential for microbial adaption to changing copper levels within the host during infection. In the opportunistic fungal pathogen Cryptococcus neoformans (Cn), the Cn Cbi1/Bim1 protein is a newly identified copper bi
Externí odkaz:
https://doaj.org/article/8aa673c0ea3e4b4ba86626efcff9d0ae
Publikováno v:
Biochemical and Biophysical Research Communications. 663:171-178