Zobrazeno 1 - 10
of 139
pro vyhledávání: '"J. Thaddeus Beck"'
Autor:
Peter A. Fasching, J. Thaddeus Beck, Arlene Chan, Michele De Laurentiis, Francisco J. Esteva, Guy Jerusalem, Patrick Neven, Xavier Pivot, Giulia V. Bianchi, Miguel Martin, David Chandiwana, Brad Lanoue, Antonia Ridolfi, Yingbo Wang, Karen Rodriguez Lorenc, Arnd Nusch
Publikováno v:
Breast, Vol 54, Iss , Pp 148-154 (2020)
Purpose: In the MONALEESA-3 Phase III trial of patients with hormone receptor–positive human epidermal growth factor receptor–negative advanced breast cancer, ribociclib plus fulvestrant significantly improved progression-free survival (PFS) and
Externí odkaz:
https://doaj.org/article/a5b481e9a0e5458182d897e58fbb782f
Autor:
Sara M. Tolaney, Muralidhar Beeram, J. Thaddeus Beck, Alison Conlin, E. Claire Dees, Shannon L. Puhalla, Brent N. Rexer, Howard A. Burris, Komal Jhaveri, Teresa Helsten, Carlos Becerra, Kevin Kalinsky, Kathleen N. Moore, Allison M. Manuel, Andrew Lithio, Gregory L. Price, Sonya C. Chapman, Lacey M. Litchfield, Matthew P. Goetz
Publikováno v:
Frontiers in Oncology, Vol 11 (2022)
BackgroundCyclin-dependent kinases (CDK) 4 and 6 regulate G1 to S cell cycle progression and are often altered in cancers. Abemaciclib is a selective inhibitor of CDK4 and CDK6 approved for administration on a continuous dosing schedule as monotherap
Externí odkaz:
https://doaj.org/article/0ebf489cd41e4cb59d2713c43b686f6f
Autor:
Jean-Louis Pujol, MD, PhD, Johan Vansteenkiste, MD, PhD, Luis Paz-Ares Rodríguez, MD, PhD, Vanesa Gregorc, MD, Julien Mazieres, MD, PhD, Mark Awad, MD, PhD, Pasi A. Jänne, MD, PhD, Michael Chisamore, PhD, Anwar M. Hossain, MStat, Yanyun Chen, PhD, J. Thaddeus Beck, MD, FACP
Publikováno v:
JTO Clinical and Research Reports, Vol 2, Iss 11, Pp 100234- (2021)
Introduction: Abemaciclib is an oral, selective small-molecule CDK 4 and 6 inhibitor. In preclinical models, abemaciclib synergized with programmed cell death protein-1 blockade to enhance antitumor efficacy. Here, we report the safety and anticancer
Externí odkaz:
https://doaj.org/article/c9caff189596499fa7e9767a030f2c97
Autor:
Cinthia Violeta Hernandez Puente, Ping-Ching Hsu, Lora J. Rogers, Fariba Jousheghany, Eric Siegel, Susan A. Kadlubar, J. Thaddeus Beck, Issam Makhoul, Laura F. Hutchins, Thomas Kieber-Emmons, Behjatolah Monzavi-Karbassi
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Immune response to a given antigen, particularly in cancer patients, is complex and is controlled by various genetic and environmental factors. Identifying biomarkers that can predict robust response to immunization is an urgent need in clinical canc
Externí odkaz:
https://doaj.org/article/e2cd64a39bf247c885718604edef1358
Autor:
Raymond P. Perez, Eric Chen, J. Thaddeus Beck, Keisuke Shirai, David Neil Hayes, Tong Shen, John R. Baldwin, Katherine B. Bryant, Shuang He, Steve Chin
Publikováno v:
Pharmacology Research & Perspectives, Vol 7, Iss 6, Pp n/a-n/a (2019)
Abstract The pharmacokinetics and potential drug–drug interactions between cetuximab and cisplatin or carboplatin from two studies (JXBA and JXBB) were evaluated. These studies were multicenter, open‐label phase II trials designed to evaluate the
Externí odkaz:
https://doaj.org/article/cc24d75a6e42422b97db94a263522bb4
Autor:
J. Thaddeus Beck, Ryan Mantooth
Publikováno v:
Case Reports in Oncology, Vol 8, Iss 1, Pp 101-105 (2015)
Breast cancer is one of the most frequently diagnosed cancers and a leading cause of death in women worldwide. Despite significant advances in the treatment of hormone receptor-positive breast cancer, tumor metastasis occurs frequently and is associa
Externí odkaz:
https://doaj.org/article/685dc369f86d4aa981530de47b75e0a4
Autor:
Elizabeth Evans, Nagashree Seetharamu, Crystal Mallow, Maurice Zauderer, Barbara Burtness, Marya Chaney, Alexander Spira, Conor Steuer, Tarek Mekhail, J Thaddeus Beck, Douglas Adkins, Terrence Fisher, Amber Foster, John Leonard, Nabil F Saba, Megan Baumgart, Steven Hager, Christopher Chay
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/b0d9d82d46d944f0bc9f5f99a3a31fd0
Autor:
Craig E. Devoe, H. Michael Shepard, Ping Jiang, Samuel Dychter, Natarajan Raghunand, Ronald Korn, Randall F. Holcombe, Oleg A. Gladkov, Sergei A. Tjulandin, Eduard M. Pshevlotsky, Stephanie A. Wagner, Boris A. Berdov, J. Thaddeus Beck, William P. Harris, Sunil R. Hingorani
1) Supplementary Table 1. Summary of imaging assessment. 2) Supplementary Table 2. Efficacy results by HA content and dose level of PEGPH20. 3) Supplementary Figure 1. Change from baseline in serum CA19-9 concentration for treated patients. 4) Supple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06c592d69198d7808723d6cda5f3366a
https://doi.org/10.1158/1078-0432.22458756
https://doi.org/10.1158/1078-0432.22458756
Autor:
Clifford A. Hudis, Nathalie A. Lokker, Sunhee Kwon Ro, Alexander Starr, Rubina Qamar, Diana C. Medgyesy, Ellis Levine, Mark Keaton, Richard Emanuelson, Peter Eisenberg, Jeffrey J. Kirshner, Katherine Bell-McGuinn, Wei Wang, Hope S. Rugo, Edward J. Stepanski, Virginia Kaklamani, J. Thaddeus Beck, Claudine Isaacs, Grace Makari-Judson, Robert C. Hermann, Kurt W. Tauer, Lee S. Schwartzberg
PDF file - 55K, Study Drug Dosing (Safety Population)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19c4e3025c6f5aa3ba9893bbb6839078
https://doi.org/10.1158/1078-0432.22447572.v1
https://doi.org/10.1158/1078-0432.22447572.v1
Autor:
Craig E. Devoe, H. Michael Shepard, Ping Jiang, Samuel Dychter, Natarajan Raghunand, Ronald Korn, Randall F. Holcombe, Oleg A. Gladkov, Sergei A. Tjulandin, Eduard M. Pshevlotsky, Stephanie A. Wagner, Boris A. Berdov, J. Thaddeus Beck, William P. Harris, Sunil R. Hingorani
Purpose: This phase Ib study evaluated the safety and tolerability of PEGylated human recombinant hyaluronidase (PEGPH20) in combination with gemcitabine (Gem), and established a phase II dose for patients with untreated stage IV metastatic pancreati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf1d1f67e02547529ace826ff367841f
https://doi.org/10.1158/1078-0432.c.6524031.v1
https://doi.org/10.1158/1078-0432.c.6524031.v1