Zobrazeno 1 - 10
of 32
pro vyhledávání: '"J. T. Holt"'
Autor:
Y. Artioli, J. C. Blackford, G. Nondal, R. G. J. Bellerby, S. L. Wakelin, J. T. Holt, M. Butenschön, J. I. Allen
Publikováno v:
Biogeosciences, Vol 11, Iss 3, Pp 601-612 (2014)
The increase in atmospheric CO2 is a dual threat to the marine environment: from one side it drives climate change, leading to modifications in water temperature, circulation patterns and stratification intensity; on the other side it causes a decrea
Externí odkaz:
https://doaj.org/article/be427d788e0a4caa985b8e1569af46af
Publikováno v:
Ocean Science, Vol 8, Iss 5, Pp 903-913 (2012)
Three shelf sea models are compared against observed surface temperature and salinity in Liverpool Bay and the Irish Sea: a 7 km NEMO (Nucleus for European Modelling of the Ocean) model, and 12 km and 1.8 km POLCOMS (Proudman Oceanographic Laboratory
Externí odkaz:
https://doaj.org/article/c93d38f72fc94c8689042c91948d878c
Publikováno v:
Ocean Science, Vol 5, Iss 4, Pp 621-634 (2009)
We review mechanisms and studies of exchange between the north-east Atlantic and the adjacent shelf seas. Well-developed summer upwelling and associated filaments off Portugal and north-west Spain give exchange O(3 m2/s per unit length of shelf). Pre
Externí odkaz:
https://doaj.org/article/d1f85f655b424fba889db77eab8e0c74
Publikováno v:
The Journal of Cell Biology
Myristylation of FBR v-fos, a c-fos retroviral homologue that causes osteosarcomas in mice, determines many of its transcriptional properties in vitro. To determine whether myristylation of FBR v-fos contributes to in vivo tumorigenicity, we examined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a677a7aaea44a3a1cb9f089b92678c0
https://doi.org/10.1083/jcb.135.2.457
https://doi.org/10.1083/jcb.135.2.457
Autor:
P S, Obermiller, J T, Holt
Publikováno v:
Methods in molecular medicine. 35
The human breast and ovarian cancer susceptibility gene BRCA1 is a tumorsuppressor gene which is mutated and lost in hereditary breast and ovarian cancer, and has both alleles mutated in approximately 10-15% of cases of sporadic ovarian cancer. Studi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ba6552cd36dccced4c3875ab9e23aea6
https://pubmed.ncbi.nlm.nih.gov/21390833
https://pubmed.ncbi.nlm.nih.gov/21390833
Publikováno v:
Molecular and Cellular Biology. 12:876-882
The myristylated v-fos product, FBR murine sarcoma virus (Gag-Fos) protein, exhibits a lower level of transrepression of the serum response element (SRE) than does c-fos protein (Fos). Mutation of the N-terminal myristylation site in FBR protein rest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b906137ad8d8b5272c4f049a91201561
https://doi.org/10.1128/mcb.12.2.876
https://doi.org/10.1128/mcb.12.2.876
Publikováno v:
Molecular and Cellular Biology. 11:765-772
FBR murine sarcoma virus (gag-fos) protein, a virally transduced Fos protein, exhibits decreased gene transactivation in comparison with the cellular Fos protein. Biochemical analysis suggests that myristylation of the virally encoded N-terminal gag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a5758876b4c280b53eaa88047ee90f3
https://doi.org/10.1128/mcb.11.2.765
https://doi.org/10.1128/mcb.11.2.765
Publikováno v:
The Journal of pathology. 217(3)
Disease-associated BRCA2 mutations typically result in protein truncations that delete the phosphorylation-regulated S3291 BRCA2 domain that interacts with Rad51. BRCA2 hereditary breast cancers are usually ER+, differing from BRCA1 hereditary cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c700fa259b2f1e0ccf6e921d2329a00
https://pubmed.ncbi.nlm.nih.gov/19016568
https://pubmed.ncbi.nlm.nih.gov/19016568
Publikováno v:
Methods in enzymology. 314
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::69b4f08dd510d627ad1d9936f60040f6
https://pubmed.ncbi.nlm.nih.gov/10565035
https://pubmed.ncbi.nlm.nih.gov/10565035
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 5(7)
Gene therapy with viral vectors has shown some promise in nude mice models and in initial Phase I trials of patients with extensive metastatic cancer. A Phase I clinical trial (D. L. Tait et al., Clin. Cancer Res., 3: 1959-1968, 1997) of ovarian canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::73d13f238e0213023f7a8bf941e95d84
https://pubmed.ncbi.nlm.nih.gov/10430073
https://pubmed.ncbi.nlm.nih.gov/10430073