Zobrazeno 1 - 10
of 12
pro vyhledávání: '"J. T. Bruder"'
Publikováno v:
Gene Therapy. 11:1321-1330
Research has shown that the use of a muscle-specific promoter can reduce immune response and improve gene transfer to muscle fibers. We investigated the efficiency of direct and ex vivo gene transfer to the skeletal muscles of 6- to 8-week-old mdx mi
Autor:
JE June, Paul D. Kessler, J T Bruder, Wendy Rosebury, Imre Kovesdi, LA Perrin, D Gordon, Andrew Robertson, Joan A. Keiser
Publikováno v:
Gene Therapy. 11:512-521
Adenovirus-mediated VEGF gene delivery is being evaluated in clinical trials as a treatment for patients with vascular diseases that stem from ischemia, such as diffuse coronary artery disease and peripheral vascular disease. Although adenoviral vect
Publikováno v:
Gene Therapy. 7:587-595
Effective repeat administration of adenovirus vectors following intranasal or intravenous delivery is hindered by a strong neutralizing antibody response to the vector. Intramuscular administration of adenovirus vectors elicited a neutralizing antibo
Publikováno v:
Journal of Virology. 70:2260-2268
The serine/threonine protein kinase Raf-1 is a component of a conserved intracellular signaling cascade that controls responses to various extracellular stimuli. Transcription from several promoters, including the oncogene-responsive element in the p
Publikováno v:
Journal of Biological Chemistry. 269:8817-8825
Protein kinases and phosphatases play an important role in signal transduction. In the T cell, activation via the T cell receptor-CD3 complex results in rapid tyrosine phosphorylation of proteins, as well as subsequent increases in serine/threonine p
Autor:
K. Alexandropoulos, S. A. Qureshi, U. R. Rapp, David A. Foster, J. T. Bruder, Myunghi Rim, C K Joseph
Publikováno v:
Journal of Biological Chemistry. 267:17635-17639
v-Src activates promoters under the control of 12-O-tetradecanoylphorbol-13-acetate (TPA) response elements (TREs) and serum response elements (SREs) via two distinguishable intracellular signaling mechanisms. The induction of TRE- and SRE-mediated g
Autor:
U. R. Rapp, Vikas P. Sukhatme, Myunghi Rim, David A. Foster, S. A. Qureshi, Walter Kolch, J. T. Bruder
Publikováno v:
Scopus-Elsevier
The protein-tyrosine kinase activity of v-Src leads to the transcriptional activation of the mitogen-responsive transcription factor Egr-1. c-Raf-1 is a serine/threonine protein kinase that has been implicated in the transduction of signals induced b
Autor:
J, Troppmair, J T, Bruder, H, Munoz, P A, Lloyd, J, Kyriakis, P, Banerjee, J, Avruch, U R, Rapp
Publikováno v:
The Journal of biological chemistry. 269(9)
The protein kinase cascade Raf-MAPKK/MEK-MAPK/ERK connects protein tyrosine kinase receptors in the membrane with control of transcription factor activity in the nucleus. We have examined whether Raf is obligatory for activation of this cascade and w
Publikováno v:
Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 3(10)
Activating the protein-tyrosine kinase activity of v-Fps leads to the rapid transcriptional activation of the Egr-1 gene, which encodes a mitogen-responsive transcription factor. Activation of Egr-1 by v-Fps was insensitive to protein kinase C deplet
Publikováno v:
Oncogene. 7(9)
A dominant negative mutant of Ras, M17 Ras, was used to study the role of Ras in receptor coupling of Raf-1 and B-Raf protein serine/threonine kinases (PSKs). We found that mutant Ras blocks serum- and 12-O-tetradecanoyl phorbol 13-acetate-induced ac