Zobrazeno 1 - 10
of 237
pro vyhledávání: '"J. Swen"'
Autor:
Jonathan E. Knikman, Qinglian Zhai, Carin A. T. C. Lunenburg, Linda M. Henricks, Stefan Böhringer, Maaike van der Lee, Femke M. de Man, Steven M. Offer, Shikshya Shrestha, Geert-Jan Creemers, Arnold Baars, Vincent O. Dezentjé, Alexander L. T. Imholz, Frank J. F. Jeurissen, Johanna E. A. Portielje, Rob L. H. Jansen, Paul Hamberg, Helga J. Droogendijk, Miriam Koopman, Peter Nieboer, Marlène H. W. van de Poel, Caroline M. P. W. Mandigers, Ron H. N. van Schaik, Hans Gelderblom, Ron H. J. Mathijssen, Jan H. M. Schellens, Annemieke Cats, Henk-Jan Guchelaar, Jesse J. Swen
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-11 (2024)
Abstract Background The Alpe-DPD study (NCT02324452) demonstrated that prospective genotyping and dose-individualization using four alleles in DPYD (DPYD*2A/rs3918290, c.1236G > A/rs75017182, c.2846A > T/rs67376798 and c.1679 T > G/rs56038477) can mi
Externí odkaz:
https://doaj.org/article/b16be71c28a348628ff01bad41681526
Autor:
Sylvia D. Klomp, Anette Veringa, Jan‐Willem C. Alffenaar, Mark G. J. deBoer, Lambert F. R. Span, Henk‐Jan Guchelaar, Jesse J. Swen
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 7, Pp n/a-n/a (2024)
Abstract Voriconazole is the cornerstone of the treatment and prevention of fungal infections. While there is a good correlation between CYP2C19 genotype and voriconazole exposure during prophylactic treatment, no correlation was found in patients wi
Externí odkaz:
https://doaj.org/article/6d2407fc26434dd2b9215c84b25c3c29
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundPharmacogenomics (PGx) is a well-established concept of how genes impact medication response, with many studies demonstrating reductions in medication side effects, improved efficacy and cost effectiveness. Despite these benefits, implement
Externí odkaz:
https://doaj.org/article/d878021235cc499bae3896e4992900e9
Autor:
Denise Feick, Simeon Rüdesheim, Fatima Zahra Marok, Dominik Selzer, Helena Leonie Hanae Loer, Donato Teutonico, Sebastian Frechen, Maaike van derLee, Dirk Jan A. R. Moes, Jesse J. Swen, Matthias Schwab, Thorsten Lehr
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 8, Pp 1143-1156 (2023)
Abstract The antiarrhythmic agent quinidine is a potent inhibitor of cytochrome P450 (CYP) 2D6 and P‐glycoprotein (P‐gp) and is therefore recommended for use in clinical drug–drug interaction (DDI) studies. However, as quinidine is also a subst
Externí odkaz:
https://doaj.org/article/503a323dba2b45ac83fda9c9d5d71582
Autor:
Qinglian Zhai, Dirk Jan A. R. Moes, Teun vanGelder, Maaike van derLee, Jan‐Stephan Sanders, Frederike J. Bemelman, Johan W. deFijter, Kathrin Klein, Matthias Schwab, Jesse J. Swen
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 2, Pp n/a-n/a (2024)
Abstract CYP3A4 activity shows considerable interindividual variability. Although studies indicate 60%–80% is heritable, common single nucleotide variants (SNVs) in CYP3A4 together only explain ~10%. Transcriptional factors, such as the testis‐sp
Externí odkaz:
https://doaj.org/article/cf902441beee46b8b8ebb244b07235fe
Autor:
Margarita-Ioanna Koufaki, Vasileios Fragoulakis, Xando Díaz-Villamarín, Kariofyllis Karamperis, Athanassios Vozikis, Jesse J. Swen, Cristina L. Dávila-Fajardo, Konstantinos Z. Vasileiou, George P. Patrinos, Christina Mitropoulou
Publikováno v:
Human Genomics, Vol 17, Iss 1, Pp 1-15 (2023)
Abstract Background Cardiovascular diseases and especially Acute Coronary Syndrome (ACS) constitute a major health issue impacting millions of patients worldwide. Being a leading cause of death and hospital admissions in many European countries inclu
Externí odkaz:
https://doaj.org/article/41e170597012483583eb06f5df3ae358
Autor:
Helena Leonie Hanae Loer, Denise Feick, Simeon Rüdesheim, Dominik Selzer, Matthias Schwab, Donato Teutonico, Sebastian Frechen, Maaike van derLee, Dirk Jan A. R. Moes, Jesse J. Swen, Thorsten Lehr
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 5, Pp 724-738 (2023)
Abstract The immunosuppressant and narrow therapeutic index drug tacrolimus is metabolized mainly via cytochrome P450 (CYP) 3A4 and CYP3A5. For its pharmacokinetics (PK), high inter‐ and intra‐individual variability can be observed. Underlying ca
Externí odkaz:
https://doaj.org/article/8f442549019b44338f8e3c2b8a8de9ff
Autor:
Maaike van derLee, Jesse J. Swen
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 1, Pp 31-36 (2023)
Abstract In recent years, the use of artificial intelligence (AI) in health care has risen steadily, including a wide range of applications in the field of pharmacology. AI is now used throughout the entire continuum of pharmacology research and clin
Externí odkaz:
https://doaj.org/article/e4914a3493644e809884bcfb25071ec5
Publikováno v:
Tijdschrift voor Gerontologie en Geriatrie, Iss 5 (2023)
Patiënt A, 58 jaar, wordt naar de geriatrie verwezen door de reumatoloog in verband met apathie. Anamnese vermeldt verspringende gewrichtspijnen, rode ontstoken ogen, apathie en interesseverlies. Lichamelijk onderzoek toont rode tranende ogen, brady
Externí odkaz:
https://doaj.org/article/724076f04a084e5a936e6bf64c339993
Autor:
Laura M. de Jong, Soukayna Boussallami, Elena Sánchez-López, Martin Giera, Maarten E. Tushuizen, Menno Hoekstra, Lukas J. A. C. Hawinkels, Robert Rissmann, Jesse J. Swen, Martijn L. Manson
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: Pharmacogenetics-informed drug prescribing is increasingly applied in clinical practice. Typically, drug metabolizing phenotypes are determined based on genetic test results, whereupon dosage or drugs are adjusted. Drug-drug-interaction
Externí odkaz:
https://doaj.org/article/dfd4b7aa0cba4a3db6f51c0bbc61c879