The Plasmodium PI(4)K inhibitor KDU691 selectively inhibits dihydroartemisinin-pretreated Plasmodium falciparum ring-stage parasites

Autor: L. Dembele, X. Ang, M. Chavchich, G. M. C. Bonamy, J. J. Selva, M. Yi-Xiu Lim, C. Bodenreider, B. K. S. Yeung, F. Nosten, B. M. Russell, M. D. Edstein, J. Straimer, D. A. Fidock, T. T. Diagana, P. Bifani

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)

Abstract Malaria control and elimination are threatened by the emergence and spread of resistance to artemisinin-based combination therapies (ACTs). Experimental evidence suggests that when an artemisinin (ART)-sensitive (K13 wild-type) Plasmodium fa

Externí odkaz: https://doaj.org/article/99f7a3c6162945b384400f88d2d8584f

Lactam Truncation Yields a Dihydroquinazolinone Scaffold with Potent Antimalarial Activity that Targets PfATP4.

Autor: Ashton TD; Walter and Eliza Hall Institute of Medical Research, Parkville, 3052, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, 3010, Victoria, Australia., Calic PPS; Walter and Eliza Hall Institute of Medical Research, Parkville, 3052, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, 3010, Victoria, Australia., Dans MG; Walter and Eliza Hall Institute of Medical Research, Parkville, 3052, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, 3010, Victoria, Australia., Kang Ooi Z; Walter and Eliza Hall Institute of Medical Research, Parkville, 3052, Victoria, Australia., Zhou Q; Walter and Eliza Hall Institute of Medical Research, Parkville, 3052, Victoria, Australia., Loi K; Walter and Eliza Hall Institute of Medical Research, Parkville, 3052, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, 3010, Victoria, Australia., Jarman KE; Walter and Eliza Hall Institute of Medical Research, Parkville, 3052, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, 3010, Victoria, Australia., Palandri J; Walter and Eliza Hall Institute of Medical Research, Parkville, 3052, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, 3010, Victoria, Australia., Qiu D; Research School of Biology, Australian National University, Canberra, 2601, Australia., Lehane AM; Research School of Biology, Australian National University, Canberra, 2601, Australia., Maity B; TCG Lifesciences, Kolkata, West Bengal, 700091, India., De N; TCG Lifesciences, Kolkata, West Bengal, 700091, India., Famodimu MT; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK., Delves MJ; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK., Mao EY; Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, Adelaide, 5005, Australia., Gancheva MR; Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, Adelaide, 5005, Australia., Wilson DW; Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, Adelaide, 5005, Australia., Chowdury M; School of Medicine, Deakin University, Waurn Ponds, Victoria, 3216, Australia.; Institute for Mental and Physical Health and Clinical Translation, Deakin University, Geelong, Victoria, 3216, Australia., de Koning-Ward TF; School of Medicine, Deakin University, Waurn Ponds, Victoria, 3216, Australia.; Institute for Mental and Physical Health and Clinical Translation, Deakin University, Geelong, Victoria, 3216, Australia., Baud D; MMV Medicines for Malaria Venture, ICC, Route de Pré-Bois 20, 1215, Geneva, Switzerland., Brand S; MMV Medicines for Malaria Venture, ICC, Route de Pré-Bois 20, 1215, Geneva, Switzerland., Jackson PF; Emerging Science & Innovation, Discovery Sciences, Janssen R&D LLC, La Jolla, California, 92121, USA., Cowman AF; Walter and Eliza Hall Institute of Medical Research, Parkville, 3052, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, 3010, Victoria, Australia., Sleebs BE; Walter and Eliza Hall Institute of Medical Research, Parkville, 3052, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, 3010, Victoria, Australia.

Publikováno v: ChemMedChem [ChemMedChem] 2024 Dec 16; Vol. 19 (24), pp. e202400549. Date of Electronic Publication: 2024 Oct 29.

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