Zobrazeno 1 - 10
of 351
pro vyhledávání: '"J. Stoermer"'
Autor:
Wilko Duprez, Prabhakar Bachu, Martin J Stoermer, Stephanie Tay, Róisín M McMahon, David P Fairlie, Jennifer L Martin
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0133805 (2015)
Antibacterial drugs with novel scaffolds and new mechanisms of action are desperately needed to address the growing problem of antibiotic resistance. The periplasmic oxidative folding system in Gram-negative bacteria represents a possible target for
Externí odkaz:
https://doaj.org/article/2f95337ff29749fc959b5c5d047c8662
Autor:
Martin J. Stoermer
A regional outbreak of pneumonia in Wuhan, Hubei Province of China in late 2019 was associated with a novel coronavirus. Rapid release of genomic data for the isolated virus enabled the construction of first-generation homology models of the new CoV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a867b1d57a93be48d12716b6eab5d5c2
https://doi.org/10.26434/chemrxiv.11637294.v3
https://doi.org/10.26434/chemrxiv.11637294.v3
Autor:
Martin J. Stoermer
The December 2019 outbreak of pneumonia in Wuhan, Hubei Province of China was rapidly linked to a novel coronavirus 2019-nCoV. The rapid spread and severity of the virus has led the World Health Organization to declare it a Public Health Emergency of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f4d4f3c372a1f4aba46596feefd05fd
https://doi.org/10.26434/chemrxiv.11799705.v1
https://doi.org/10.26434/chemrxiv.11799705.v1
Autor:
Martin J. Stoermer
A regional outbreak of pneumonia in Wuhan, Hubei Province of China in late 2019 was associated with a novel coronavirus. Rapid release of genomic data for the isolated virus enabled the construction of first-generation homology models of the new CoV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21954de20b2018ed38b3f8ef60986293
https://doi.org/10.26434/chemrxiv.11637294.v2
https://doi.org/10.26434/chemrxiv.11637294.v2
Autor:
Martin J. Stoermer
A regional outbreak of pneumonia in Wuhan, Hubei Province of China in late 2019 was associated with a novel coronavirus. Rapid release of genomic data for the isolated virus enabled the construction of first-generation homology models of the new CoV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d5a24165486229c348e6fae6ca745c2
https://doi.org/10.26434/chemrxiv.11637294.v1
https://doi.org/10.26434/chemrxiv.11637294.v1
Autor:
Jeffrey Y. W. Mak, David P. Fairlie, Allan H. White, Martin J. Stoermer, Alexandre N. Sobolev, David C. R. Hockless, Karl A. Byriel, Brian W. Skelton, W. A. Wickramasinghe
Publikováno v:
European Journal of Organic Chemistry. 2017:6793-6796
The formal cycloaddition adduct of 1,4-benzoquinone with two equivalents of cyclopentadiene is a scaffold with two non-conjugated alkenes. Both alkenes undergo endo [4+2] cycloaddition with a diene to form a rigid U-shaped molecular cleft. Here we sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c9a1a9adc4d3760670133386b4e2dfd
https://doi.org/10.1002/ejoc.201701319
https://doi.org/10.1002/ejoc.201701319
Autor:
Karla J. Stoermer-Grossman, Ixsy A. Ramirez, Toby C. Lewis, Manuel Arteta, Kelley M. Kidwell, Khalid H. Safi, Julie Sturza, Thomas G. Saba, Marc B. Hershenson
Publikováno v:
Pediatric Allergy, Immunology, and Pulmonology. 29:17-23
We evaluated the impact of a comprehensive pediatric asthma management program (the Children's Asthma Wellness Program, CAWP) on the frequency of emergency department (ED) visits and hospital admissions. The CAWP generally consisted of 4 clinic sessi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2afc5fc84e6332c5cd2b2392f1a9d988
https://doi.org/10.1089/ped.2015.0561
https://doi.org/10.1089/ped.2015.0561
Autor:
Martin J. Stoermer, Weijun Xu, David P. Fairlie, Andrew J. Lucke, Daniel S. Nielsen, Nicholas E. Shepherd
Publikováno v:
Chemical reviews. 117(12)
Peptides and proteins are not orally bioavailable in mammals, although a few peptides are intestinally absorbed in small amounts. Polypeptides are generally too large and polar to passively diffuse through lipid membranes, while most known active tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f63d6040bf01c33967b2f142651b505f
https://pubmed.ncbi.nlm.nih.gov/28541045
https://pubmed.ncbi.nlm.nih.gov/28541045
Autor:
Robert Reid, Ranee Singh, Mei-Kwan Yau, David P. Fairlie, Junxian Lim, Martin J. Stoermer, Johan K. Hamidon
Publikováno v:
Journal of Medicinal Chemistry. 57:8459-8470
The G-protein coupled receptor (C3aR) for human inflammatory protein complement C3a is an important component of immune, inflammatory, and metabolic diseases. A flexible compound (N2-[(2,2-diphenylethoxy)acetyl]-l-arginine, 4), known as a weak C3aR a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28f4610fa08861a6941697b347bfe4e3
https://doi.org/10.1021/jm500956p
https://doi.org/10.1021/jm500956p
Autor:
Barbara Colless, Stephanie Chaousis, Timothy A. Hill, Martin J. Stoermer, Andrew J. Lucke, Rink-Jan Lohman, Ligong Liu, Daniel S. Nielsen, Spiros Liras, Roger B. Ruggeri, Charles J. Rotter, Conor C G Scully, David J. Edmonds, Huy N. Hoang, W. Mei Kok, David Price, David P. Fairlie, Paul V. Bernhardt, David A. Griffith, Christina I. Schroeder, David J. Craik
Publikováno v:
ACS Medicinal Chemistry Letters. 5:1148-1151
Development of peptide-based drugs has been severely limited by lack of oral bioavailability with less than a handful of peptides being truly orally bioavailable, mainly cyclic peptides with N-methyl amino acids and few hydrogen bond donors. Here we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0776d1fb6036db55fc9f76aad6682322
https://doi.org/10.1021/ml5002823
https://doi.org/10.1021/ml5002823