Zobrazeno 1 - 10
of 69
pro vyhledávání: '"J. Steyer"'
Autor:
Alexandra C. Sun, Daniel J. Steyer, Anthony R. Allen, Emory M. Payne, Robert T. Kennedy, Corey R. J. Stephenson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-6 (2020)
Translating discovery scale vial-based batch reactions to continuous flow scale-up conditions is limited by significant time and resource constraints. Here, the authors report a photochemical droplet microfluidic platform, which enables high throughp
Externí odkaz:
https://doaj.org/article/aec33517a74540628771a347128e1c41
Autor:
Alexandra C. Sun, Daniel J. Steyer, Richard I. Robinson, Carol Ginsburg‐Moraff, Scott Plummer, Jinhai Gao, Joseph W. Tucker, Dirk Alpers, Corey R. J. Stephenson, Robert T. Kennedy
Publikováno v:
Angewandte Chemie International Edition.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59464e51e5d2c31b8ffddc7ea65ec040
https://doi.org/10.1002/anie.202301664
https://doi.org/10.1002/anie.202301664
Publikováno v:
Analytical chemistry. 94(38)
Native mass spectrometry coupled to ion mobility (IM-MS) has become an important tool for the investigation of protein structure and dynamics upon ligand binding. Additionally, collisional activation or collision induced unfolding (CIU) can further p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::affe6e74fa37dd277d775015edefd109
https://pubmed.ncbi.nlm.nih.gov/36098981
https://pubmed.ncbi.nlm.nih.gov/36098981
Autor:
Emmanuel O. Ogunkunle, Matthew J. Donohue, Daniel J. Steyer, Damilola I. Adeoye, Wesley J. Eaton, Michael G. Roper
Publikováno v:
Analytical methods : advancing methods and applications. 14(21)
Islets of Langerhans are the endocrine tissue within the pancreas that secrete hormones for maintenance of blood glucose homeostasis. A variety of small molecules including classical neurotransmitters are also released from islets. While the roles of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e2b0308b7537e78a076a25a57e5c893
https://pubmed.ncbi.nlm.nih.gov/35567801
https://pubmed.ncbi.nlm.nih.gov/35567801
Autor:
Daniel J. Steyer, Robert T. Kennedy
Publikováno v:
Anal Chem
Droplet microfluidics enables high-throughput manipulation of fL-μL volume samples. Methods implemented for the chemical analysis of microfluidic droplets have been limited in scope, leaving some applications of droplet microfluidics difficult to pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::681208481a1241c676df4b9090ff80c5
https://doi.org/10.1021/acs.analchem.9b00571
https://doi.org/10.1021/acs.analchem.9b00571
An LC-MS method using multiple reaction monitoring for quantitation of insulin, C-peptide, glucagon, and somatostatin secretion from human islet populations is described. A 5 min separation was developed using a 2.1 × 30 mm (i.d. x length) C18 colum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::286c51111f8c8b8920b0b1082f5e466a
https://doi.org/10.17504/protocols.io.buw9nxh6
https://doi.org/10.17504/protocols.io.buw9nxh6
Autor:
Daniel J. Steyer, Robert T. Kennedy, Alexandra C. Sun, Emory M. Payne, Anthony R. Allen, Corey R. J. Stephenson
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-6 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-6 (2020)
The implementation of continuous flow technology is critical towards enhancing the application of photochemical reactions for industrial process development. However, there are significant time and resource constraints associated with translating dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e42df45686adef978006c48896a984a
http://europepmc.org/articles/PMC7712835
http://europepmc.org/articles/PMC7712835
Autor:
Daniel J. Steyer, Robert T. Kennedy, Corey R. J. Stephenson, Anthony R. Allen, Emory M. Payne, Sun A
We report the development of a droplet microfluidic/mass spectrometry platform for performing high-throughput photochemical reaction discovery on picomole scale. We also describe the successful translation of picomole scale flow screening conditions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed0a9ee91c4f669cb744d8f0a43586ba
https://doi.org/10.26434/chemrxiv.12123978.v1
https://doi.org/10.26434/chemrxiv.12123978.v1
Publikováno v:
International Journal of Biomedical Imaging, Vol 2012 (2012)
We developed and evaluated an algorithm for enumerating fluorescently labeled cells (e.g., stem and cancer cells) in mouse-sized, microscopic-resolution, cryo-image volumes. Fluorescent cell clusters were detected, segmented, and then fit with a mode
Externí odkaz:
https://doaj.org/article/df461fc781f64450b0c37bce78e74d90
Publikováno v:
Analytical Chemistry. 90:10943-10950
An essential approach for in vivo chemical monitoring is to use sampling probes coupled with analytical methods; however, this method traditionally has limited spatial and temporal resolution. To address this problem, we have developed an analytical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0d3b24d8eb79d7d8baf92c155d6654c
https://doi.org/10.1021/acs.analchem.8b02468
https://doi.org/10.1021/acs.analchem.8b02468