Zobrazeno 1 - 10
of 109
pro vyhledávání: '"J. Sterckx"'
Autor:
Kwabena F.M. Opuni, Manuela Ruß, Rob Geens, Line De Vocht, Pieter Van Wielendaele, Christophe Debuy, Yann G.-J. Sterckx, Michael O. Glocker
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 3300-3314 (2024)
Background: Bioanalytical methods that enable rapid and high-detail characterization of binding specificities and strengths of protein complexes with low sample consumption are highly desired. The interaction between a camelid single domain antibody
Externí odkaz:
https://doaj.org/article/f588cf0ec2c44023b04b9b3a3fddf5b2
Autor:
Hagen Sülzen, Alexander N Volkov, Rob Geens, Farnaz Zahedifard, Benoit Stijlemans, Martin Zoltner, Stefan Magez, Yann G-J Sterckx, Sebastian Zoll
Publikováno v:
PLoS Pathogens, Vol 20, Iss 4, p e1012186 (2024)
In the bloodstream of mammalian hosts, African trypanosomes face the challenge of protecting their invariant surface receptors from immune detection. This crucial role is fulfilled by a dense, glycosylated protein layer composed of variant surface gl
Externí odkaz:
https://doaj.org/article/0ae2a89c4ccd486dacda8a4e16e9ce6f
Autor:
Laura Dirkx, Sara I Van Acker, Yasmine Nicolaes, João Luís Reis Cunha, Rokaya Ahmad, Rik Hendrickx, Ben Caljon, Hideo Imamura, Didier G Ebo, Daniel C Jeffares, Yann G-J Sterckx, Louis Maes, Sarah Hendrickx, Guy Caljon
Publikováno v:
PLoS Pathogens, Vol 20, Iss 4, p e1012181 (2024)
Addressing the challenges of quiescence and post-treatment relapse is of utmost importance in the microbiology field. This study shows that Leishmania infantum and L. donovani parasites rapidly enter into quiescence after an estimated 2-3 divisions i
Externí odkaz:
https://doaj.org/article/c3328a026fb045d3b54dc41a434fc149
Autor:
Natalia Smiejkowska, Lauren Oorts, Kevin Van Calster, Linda De Vooght, Rob Geens, Henri-Philippe Mattelaer, Koen Augustyns, Sergei V. Strelkov, Dirk Lamprecht, Koen Temmerman, Yann G.-J. Sterckx, Davie Cappoen, Paul Cos
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 3 (2024)
ABSTRACTThe World Health Organization’s goal to combat tuberculosis (TB) is hindered by the emergence of anti-microbial resistance, therefore necessitating the exploration of new drug targets. Multidrug regimens are indispensable in TB therapy as t
Externí odkaz:
https://doaj.org/article/c8fac40f6384460fafe887ecb260e268
Autor:
Gabriela Llauger, Roberto Melero, Demián Monti, Gabriela Sycz, Cristián Huck-Iriart, María L. Cerutti, Sebastián Klinke, Evelyn Mikkelsen, Ariel Tijman, Rocío Arranz, Victoria Alfonso, Sofía M. Arellano, Fernando A. Goldbaum, Yann G. J. Sterckx, José-María Carazo, Sergio B. Kaufman, Pablo D. Dans, Mariana del Vas, Lisandro H. Otero
Publikováno v:
mBio, Vol 14, Iss 2 (2023)
ABSTRACT Fijiviruses replicate and package their genomes within viroplasms in a process involving RNA-RNA and RNA-protein interactions. Here, we demonstrate that the 24 C-terminal residues (C-arm) of the P9-1 major viroplasm protein of the mal de Rí
Externí odkaz:
https://doaj.org/article/47601c9d422e4d1aa16f2724f43f127c
Autor:
Aya Hefnawy, Gabriel Negreira, Marlene Jara, James A. Cotton, Ilse Maes, Erika D’Haenens, Hideo Imamura, Bart Cuypers, Pieter Monsieurs, Christina Mouchtoglou, Hans De Winter, Isabel Pintelon, Jean-Pierre Timmermans, Matt Berriman, Mandy Sanders, Julio Martin, Geraldine de Muylder, Jean-Claude Dujardin, Yann G.-J. Sterckx, Malgorzata Anna Domagalska
Publikováno v:
mBio, Vol 13, Iss 1 (2022)
ABSTRACT The implementation of prospective drug resistance (DR) studies in the research-and-development (R&D) pipeline is a common practice for many infectious diseases but not for neglected tropical diseases (NTDs). Here, we explored and demonstrate
Externí odkaz:
https://doaj.org/article/e80a58f28d3e4a0b837c97b9b12a4bca
Autor:
Steven Odongo, Hedmon Okella, Christian Ndekezi, Moses Okee, Monica Namayanja, Brian Mujuni, Yann G J Sterckx, Dennison Kizito, Magdalena Radwanska, Stefan Magez, Kokas Ikwap, Frank Nobert Mwiine, Julius Julian Lutwama, Charles Ibingira
Publikováno v:
PLoS ONE, Vol 17, Iss 12, p e0279428 (2022)
The SARS-CoV-2 virus, the agent of COVID-19, caused unprecedented loss of lives and economic decline worldwide. Although the introduction of public health measures, vaccines, diagnostics, and therapeutics disrupted the spread of the SARS-CoV-2, the e
Externí odkaz:
https://doaj.org/article/a66faa92a1e94e999158a773edfe783e
Autor:
Chloé Ackaert, Natalia Smiejkowska, Catarina Xavier, Yann G. J. Sterckx, Sofie Denies, Benoit Stijlemans, Yvon Elkrim, Nick Devoogdt, Vicky Caveliers, Tony Lahoutte, Serge Muyldermans, Karine Breckpot, Marleen Keyaerts
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Nanobodies (Nbs), the variable domains of camelid heavy chain-only antibodies, are a promising class of therapeutics or in vivo imaging reagents entering the clinic. They possess unique characteristics, including a minimal size, providing fast pharma
Externí odkaz:
https://doaj.org/article/d0675eea2e384e6ba27da35657ce2a41
Autor:
Zeng Li, Joar Esteban Pinto Torres, Julie Goossens, Benoit Stijlemans, Yann G-J Sterckx, Stefan Magez
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 2, p e0008044 (2020)
BACKGROUND:Animal trypanosomosis caused by Trypanosoma evansi is known as "surra" and is a widespread neglected tropical disease affecting wild and domestic animals mainly in South America, the Middle East, North Africa and Asia. An essential necessi
Externí odkaz:
https://doaj.org/article/bdb16b6ff20b47cbac3dcf5bf08ea51f
Autor:
Joar E. Pinto Torres, Julie Goossens, Jianzu Ding, Zeng Li, Shaohong Lu, Didier Vertommen, Peter Naniima, Rui Chen, Serge Muyldermans, Yann G.-J. Sterckx, Stefan Magez
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Abstract Animal African trypanosomosis (AAT), a disease affecting livestock, is caused by parasites of the Trypanosoma genus (mainly T. vivax and T. congolense). AAT is widespread in Sub-Saharan Africa, where it continues to impose a heavy socio-econ
Externí odkaz:
https://doaj.org/article/b0ab489491d949b589362f495b917920