Zobrazeno 1 - 10
of 44
pro vyhledávání: '"J. Stephen Fink"'
Autor:
J. Stephen Fink, James M. Schumacher, Samuel L. Ellias, E. Prather Palmer, Marie Saint-Hilaire, Kathleen Shannon, Richard Penn, Philip Starr, Craig Vanhorne, H. Stephen Kott M.D., Ph.D., Peter K. Dempsey, Alan J. Fischman, Ronald Raineri, Carolyn Manhart, Jonathan Dinsmore, Ole Isacson
Publikováno v:
Cell Transplantation, Vol 9 (2000)
The observation that fetal neurons are able to survive and function when transplanted into the adult brain fostered the development of cellular therapy as a promising approach to achieve neuronal replacement for treatment of diseases of the adult cen
Externí odkaz:
https://doaj.org/article/de6ee9c808c9450c8c89b0fb87edb67c
Autor:
Sumio Sugano, Michael A. Schwarzschild, Zhiping Weng, Yutaka Suzuki, Jiang-Fan Chen, Tom Gearan, Martin C. Frith, Liqun Yu, Robert A. Peterfreund, J. Stephen Fink
Publikováno v:
Brain Research. 1000:156-173
The adenosine A(2A) receptor (A(2A)R) is abundantly expressed in brain and emerging as an important therapeutic target for Parkinson's disease and potentially other neuropsychiatric disorders. To understand the molecular mechanisms of A(2A)R gene exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c538b515f630d2b60506390d975d884
https://doi.org/10.1016/j.brainres.2003.11.072
https://doi.org/10.1016/j.brainres.2003.11.072
Autor:
Anti Kalda, Hoon Ryu, J. Stephen Fink, Michael A. Schwarzschild, Jiang-Fan Chen, Edward C. Stack, Robert J. Ferrante
Publikováno v:
Journal of Neurochemistry. 88:538-544
Adenosine A2A receptor (A2AR) antagonism attenuates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurodegeneration and quinolinic acid-induced excitotoxicity in the neostriatum. As A2ARs are enriched in striatum, we investigated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c90977a57ce0bb7513b1a2b0e9cd06e8
https://doi.org/10.1046/j.1471-4159.2003.02145.x
https://doi.org/10.1046/j.1471-4159.2003.02145.x
Autor:
Liping Huang, Michael A. Schwarzschild, Jiang-Fan Chen, Joel Linden, Marcia McDuffie, Hong Ye, J. Stephen Fink, Mark D. Okusa, Yuan-Ji Day, Diane L. Rosin
Publikováno v:
Journal of Clinical Investigation. 112:883-891
Activation of A2A adenosine receptors (A2ARs) protects kidneys from ischemia-reperfusion injury (IRI). A2ARs are expressed on bone marrow-derived (BM-derived) cells and renal smooth muscle, epithelial, and endothelial cells. To measure the contributi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f686bf6101bcf9cf567b49f9108c8272
https://doi.org/10.1172/jci15483
https://doi.org/10.1172/jci15483
Autor:
Marlene A. Jacobson, Bruce N. Cronstein, Dave Delano, J. Stephen Fink, Jiang-Fan Chen, Avani Desai, M. Carmen Montesinos
Publikováno v:
Arthritis & Rheumatism. 48:240-247
Objective Low-dose weekly methotrexate therapy remains a mainstay in the treatment of inflammatory arthritis. Results of previous studies demonstrated that adenosine, acting at one or more of its receptors, mediates the antiinflammatory effects of me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19d9f717f7aaba00e3268536647c520a
https://doi.org/10.1002/art.10712
https://doi.org/10.1002/art.10712
Autor:
J. Stephen Fink, Susan E. Lewis, Lila K. Hamill, Steven E. Hyman, Michael A. Schwarzschild, William T. Dauer
Publikováno v:
Journal of Neurochemistry. 63:1246-1254
The cytokines leukemia inhibitory factor (LIF) and ciliary neurotrophic factor (CNTF) have been implicated in determination of neuronal phenotype as well as promotion of neuronal survival. However, the intracellular mechanisms by which their signals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3211c99df6f5885e66732cde389108b2
https://doi.org/10.1046/j.1471-4159.1994.63041246.x
https://doi.org/10.1046/j.1471-4159.1994.63041246.x
Autor:
Michael A. Schwarzschild, J. Stephen Fink, Marcelo Rubinstein, Rosario Moratalla, Mark A. Beilstein, Elizabeth Hackett, Jiang-Fan Chen, Ennio Ongini, David K. Grandy, Malcolm J. Low, Francesco Impagnatiello, Beatriz Cuellar
Publikováno v:
Proceedings of the National Academy of Sciences. 98:1970-1975
The A 2A R is largely coexpressed with D 2 Rs and enkephalin mRNA in the striatum where it modulates dopaminergic activity. Activation of the A 2A R antagonizes D 2 R-mediated behavioral and neurochemical effects in the basal ganglia through a mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10ee85e5dc5d2fca7d3c8f6964400bf8
https://doi.org/10.1073/pnas.98.4.1970
https://doi.org/10.1073/pnas.98.4.1970
Autor:
Christine Klein, Karla Schilling, Rachel J. Saunders‐Pullman, Jennifer Garrels, Xandra O. Breakefield, Mitchell F. Brin, Deborah deLeon, Dana Doheny, Stanley Fahn, J. Stephen Fink, Lars Forsgren, Jennifer Friedman, Steven Frucht, Juliette Harris, Gosta Holmgren, Bernhard Kis, Roger Kurlan, Martin Kyllerman, Anthony E. Lang, Joanne Leung, Deborah Raymond, Janet D. Robishaw, Gunnar Sanner, Eberhard Schwinger, Rowena E. Tabamo, Michele Tagliati, Peter Vieregge, Jan Wahlstrom, Kristin J. Wendt, Patricia L. Kramer, Susan B. Bressman, Laurie J. Ozelius
Publikováno v:
The American Journal of Human Genetics. 67:1314-1319
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aef3ca9163308ed5d1675d5ed7463e27
https://doi.org/10.1086/321193
https://doi.org/10.1086/321193
Autor:
Michael A. Schwarzschild, Sergey Apasov, Patrick T. Smith, Jiang-Fan Chen, Michail V. Sitkovsky, J. Stephen Fink
Publikováno v:
British Journal of Pharmacology. 131:43-50
Cell surface A2A adenosine receptor (A2AR) mediated signalling affects a variety of important processes and adenosine analogues possess promising pharmacological properties. Demonstrating the receptor specificity of potentially lymphotoxic adenosine-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab349093b14b649268eb509ec6dfe690
https://doi.org/10.1038/sj.bjp.0703532
https://doi.org/10.1038/sj.bjp.0703532
Publikováno v:
Brain Research. 802:198-204
We have used the response of the superior cervical ganglia (SCG) to axotomy to investigate interactions between neuropoietic cytokines and neurotrophins. Postganglionic sympathetic axotomy leads to a prolonged leukemia inhibitory factor (LIF)-depende
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5981e010f8bdac86f691185cf0d1f465
https://doi.org/10.1016/s0006-8993(98)00611-8
https://doi.org/10.1016/s0006-8993(98)00611-8