Zobrazeno 1 - 10
of 304
pro vyhledávání: '"J. Stephen Dumler"'
Autor:
Paul W. Blair, Kenneth Kobba, Stephen Okello, Sultanah Alharthi, Prossy Naluyima, Emily Clemens, Hannah Kibuuka, Danielle V. Clark, Francis Kakooza, Mohammed Lamorde, Yukari C. Manabe, J. Stephen Dumler, Acute Febrile Illness
Publikováno v:
Emerging Infectious Diseases, Vol 30, Iss 7, Pp 1442-1446 (2024)
At 3 severe infection cohort sites in Uganda, Orientia seropositivity was common. We identified 4 seroconversion cases and 1 PCR-positive case. These results provide serologic and molecular support for Orientia spp. circulating in sub-Saharan Africa,
Externí odkaz:
https://doaj.org/article/03b48287b06e468baaf9c6ad0f9943f4
Autor:
Abraham J Kandathil, Paul W Blair, Jennifer Lu, Raghavendran Anantharam, Kenneth Kobba, Matthew L Robinson, Sultanah Alharthi, Edgar C Ndawula, J Stephen Dumler, Francis Kakooza, Mohammed Lamorde, David L Thomas, Steven L Salzberg, Yukari C Manabe
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 18, Iss 9, p e0012451 (2024)
Metagenomic next generation metagenomic sequencing (mNGS) has proven to be a useful tool in the diagnosis and identification of novel human pathogens and pathogens not identified on routine clinical microbiologic tests. In this study, we applied mNGS
Externí odkaz:
https://doaj.org/article/ede602405b7a41ab964a1ce3530e2cae
Autor:
Emily R. Ko, Megan E. Reller, L. Gayani Tillekeratne, Champica K. Bodinayake, Cameron Miller, Thomas W. Burke, Ricardo Henao, Micah T. McClain, Sunil Suchindran, Bradly Nicholson, Adam Blatt, Elizabeth Petzold, Ephraim L. Tsalik, Ajith Nagahawatte, Vasantha Devasiri, Matthew P. Rubach, Venance P. Maro, Bingileki F. Lwezaula, Wasantha Kodikara-Arachichi, Ruvini Kurukulasooriya, Aruna D. De Silva, Danielle V. Clark, Kevin L. Schully, Deng Madut, J. Stephen Dumler, Cecilia Kato, Renee Galloway, John A. Crump, Geoffrey S. Ginsburg, Timothy D. Minogue, Christopher W. Woods
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Diagnostic limitations challenge management of clinically indistinguishable acute infectious illness globally. Gene expression classification models show great promise distinguishing causes of fever. We generated transcriptional data for a 2
Externí odkaz:
https://doaj.org/article/6b810e23001a49d88802db46e9e5c9d3
Autor:
Andrés F Londoño, Jennifer M Farner, Marlon Dillon, Dennis J Grab, Yuri Kim, Diana G Scorpio, J Stephen Dumler
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 18, Iss 2, p e0011993 (2024)
Spotted fever group rickettsiae are tick-borne obligate intracellular bacteria that infect microvascular endothelial cells. Humans and mammalian infection results in endothelial cell barrier dysfunction and increased vascular permeability. We previou
Externí odkaz:
https://doaj.org/article/303aaa7626214e9fa6ff891afd627703
Autor:
Marcos Rogério André, Priscila Ikeda, Daniel Antônio Braga Lee, Renan Bressianini do Amaral, Lucas Amoroso Lopes Carvalho, Daniel Guariz Pinheiro, Jaire Marinho Torres, Victória Valente Califre de Mello, Gregory K. Rice, Regina Z. Cer, Elizabete Captivo Lourenço, Carisa Elisei Oliveira, Heitor Miraglia Herrera, Darci Moraes Barros-Battesti, Rosangela Zacarias Machado, Kimberly A. Bishop-Lilly, Clifton L. Dalgard, J. Stephen Dumler
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
IntroductionBats, along with their ectoparasites, harbor a wide diversity of symbiotic and potential pathogenic bacteria. Despite the enormous diversity of bats (181 species), few studies aimed to investigate the bacterial microbiome of Brazilian chi
Externí odkaz:
https://doaj.org/article/8c8afb9453df454fa036df36879788cf
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
Rickettsial agents are a diverse group of alpha-proteobacteria within the order Rickettsiales, which possesses two families with human pathogens, Rickettsiaceae and Anaplasmataceae. These obligate intracellular bacteria are most frequently transmitte
Externí odkaz:
https://doaj.org/article/719eec70b97646b78a0a3349fea2a0db
Autor:
Zhaobin Guo, Nan Zhao, Tracy D. Chung, Anjan Singh, Ikshu Pandey, Linus Wang, Xinyue Gu, Aisha Ademola, Raleigh M. Linville, Utpal Pal, J. Stephen Dumler, Peter C. Searson
Publikováno v:
Advanced Science, Vol 9, Iss 35, Pp n/a-n/a (2022)
Abstract Lyme disease is a tick‐borne disease prevalent in North America, Europe, and Asia. Despite the accumulated knowledge from epidemiological, in vitro, and in animal studies, the understanding of dissemination of vector‐borne pathogens, suc
Externí odkaz:
https://doaj.org/article/8b58abd72416402cbf9484cb6dd46537
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Anaplasma phagocytophilum, a tick-borne obligately intracellular bacterium of neutrophils, causes human granulocytic anaplasmosis. Ankyrin A (AnkA), an effector protein with multiple ankyrin repeats (AR) is injected via type IV-secretion into the hos
Externí odkaz:
https://doaj.org/article/4a7ef48f2cbf447fa9c937a9c3346678
Autor:
Matthew J. Grigg, Timothy William, Emily G. Clemens, Kaajal Patel, Arjun Chandna, Christopher S. Wilkes, Bridget E. Barber, Nicholas M. Anstey, J. Stephen Dumler, Tsin W. Yeo, Megan E. Reller
Publikováno v:
Emerging Infectious Diseases, Vol 26, Iss 7, Pp 1409-1419 (2020)
Orientia tsutsugamushi, spotted fever group rickettsioses, and typhus group rickettsioses (TGR) are reemerging causes of acute febrile illness (AFI) in Southeast Asia. To further delineate extent, we enrolled patients >4 weeks of age with nonmalarial
Externí odkaz:
https://doaj.org/article/142b02aab77340f3a0aedc41366918d7
Autor:
Joost Brandsma, Josh G Chenoweth, Melissa K Gregory, Subramaniam Krishnan, Paul W Blair, Deborah A Striegel, Rittal Mehta, Kevin L Schully, J Stephen Dumler, Cdr Cynthia S Sikorski, Kelsey O'Connor, Susan A Reichert-Scrivner, Carmen M Paguirigan, Catherine F T Uyehara, Col Viseth Ngauy, Christopher A Myers, Danielle V Clark
Publikováno v:
PLoS ONE, Vol 17, Iss 8, p e0272572 (2022)
BackgroundVenous phlebotomy performed by trained personnel is critical for patient diagnosis and monitoring of chronic disease, but has limitations in resource-constrained settings, and represents an infection control challenge during outbreaks. Self
Externí odkaz:
https://doaj.org/article/9ab084dd987146e1ae97ef249231302c