Zobrazeno 1 - 10
of 57
pro vyhledávání: '"J. Stehbens"'
Autor:
Teodor E. Yordanov, Mikaela S. Keyser, Marco A. Enriquez Martinez, Tyron Esposito, Juliann B. Tefft, Elysse K. Morris, Larisa I. Labzin, Samantha J. Stehbens, Alan E. Rowan, Benjamin M. Hogan, Christopher S. Chen, Jan Lauko, Anne K. Lagendijk
Publikováno v:
APL Bioengineering, Vol 8, Iss 1, Pp 016108-016108-14 (2024)
Cerebral cavernous malformations (CCMs) are vascular lesions that predominantly form in blood vessels of the central nervous system upon loss of the CCM multimeric protein complex. The endothelial cells within CCM lesions are characterized by overact
Externí odkaz:
https://doaj.org/article/a60ddf22761145ba8d3826e7dbcf0896
Autor:
Sina Jami, Jennifer R. Deuis, Tabea Klasfauseweh, Xiaoyang Cheng, Sergey Kurdyukov, Felicity Chung, Andrei L. Okorokov, Shengnan Li, Jiangtao Zhang, Ben Cristofori-Armstrong, Mathilde R. Israel, Robert J. Ju, Samuel D. Robinson, Peng Zhao, Lotten Ragnarsson, Åsa Andersson, Poanna Tran, Vanessa Schendel, Kirsten L. McMahon, Hue N. T. Tran, Yanni K.-Y. Chin, Yifei Zhu, Junyu Liu, Theo Crawford, Saipriyaa Purushothamvasan, Abdella M. Habib, David A. Andersson, Lachlan D. Rash, John N. Wood, Jing Zhao, Samantha J. Stehbens, Mehdi Mobli, Andreas Leffler, Daohua Jiang, James J. Cox, Stephen G. Waxman, Sulayman D. Dib-Hajj, G. Gregory Neely, Thomas Durek, Irina Vetter
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Voltage-gated sodium (NaV) channels are critical regulators of neuronal excitability and are targeted by many toxins that directly interact with the pore-forming α subunit, typically via extracellular loops of the voltage-sensing domains, o
Externí odkaz:
https://doaj.org/article/ef7fee6301d340c5b67edc494cc4b801
Autor:
Heike Chauvistré, Batool Shannan, Sheena M. Daignault-Mill, Robert J. Ju, Daniel Picard, Stefanie Egetemaier, Renáta Váraljai, Christine S. Gibhardt, Antonio Sechi, Farnusch Kaschani, Oliver Keminer, Samantha J. Stehbens, Qin Liu, Xiangfan Yin, Kirujan Jeyakumar, Felix C. E. Vogel, Clemens Krepler, Vito W. Rebecca, Linda Kubat, Smiths S. Lueong, Jan Forster, Susanne Horn, Marc Remke, Michael Ehrmann, Annette Paschen, Jürgen C. Becker, Iris Helfrich, Daniel Rauh, Markus Kaiser, Sheraz Gul, Meenhard Herlyn, Ivan Bogeski, José Neptuno Rodríguez-López, Nikolas K. Haass, Dirk Schadendorf, Alexander Roesch
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Slow-cycling melanoma persister cells are characterised by a high, reversible expression of H3K4 demethylase KDM5B. Here, the authors use genetic and chemical methods to enforce a permanent high expression of KDM5B and show that these cells transit t
Externí odkaz:
https://doaj.org/article/37bb3c7c6ed14e8aa7ac035cb7135585
Autor:
Elysse K. Morris, Sheena Daignault-Mill, Samantha J. Stehbens, Laura A. Genovesi, Anne K. Lagendijk
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Brain tumors represent the leading cause of disease-related mortality and morbidity in children, with effective treatments urgently required. One factor limiting the effectiveness of systemic therapy is the blood-brain-barrier (BBB), which limits the
Externí odkaz:
https://doaj.org/article/2a636aab84154f5e8082e37af25f7e55
Autor:
Hiroko Katsuno-Kambe, Jessica L Teo, Robert J Ju, James Hudson, Samantha J Stehbens, Alpha S Yap
Publikováno v:
eLife, Vol 10 (2021)
Epithelial networks are commonly generated by processes where multicellular aggregates elongate and branch. Here, we focus on understanding cellular mechanisms for elongation using an organotypic culture system as a model of mammary epithelial anlage
Externí odkaz:
https://doaj.org/article/f8d14b1296864762afc74d5ceeffe548
Autor:
Leisl M. Packer, Samantha J. Stehbens, Vanessa F. Bonazzi, Jennifer H. Gunter, Robert J. Ju, Micheal Ward, Michael G. Gartside, Sara A. Byron, Pamela M. Pollock
Publikováno v:
Molecular Oncology, Vol 13, Iss 4, Pp 738-756 (2019)
Endometrial cancer is the most commonly diagnosed gynaecological malignancy. Unfortunately, 15–20% of women demonstrate persistent or recurrent tumours that are refractory to current chemotherapies. We previously identified activating mutations in
Externí odkaz:
https://doaj.org/article/234c76f07ab648e28386f7e7423d6c89
Autor:
Etai Sapoznik, Bo-Jui Chang, Jaewon Huh, Robert J Ju, Evgenia V Azarova, Theresa Pohlkamp, Erik S Welf, David Broadbent, Alexandre F Carisey, Samantha J Stehbens, Kyung-Min Lee, Arnaldo Marín, Ariella B Hanker, Jens C Schmidt, Carlos L Arteaga, Bin Yang, Yoshihiko Kobayashi, Purushothama Rao Tata, Rory Kruithoff, Konstantin Doubrovinski, Douglas P Shepherd, Alfred Millett-Sikking, Andrew G York, Kevin M Dean, Reto P Fiolka
Publikováno v:
eLife, Vol 9 (2020)
We present an oblique plane microscope (OPM) that uses a bespoke glass-tipped tertiary objective to improve the resolution, field of view, and usability over previous variants. Owing to its high numerical aperture optics, this microscope achieves lat
Externí odkaz:
https://doaj.org/article/2e2ea231dd3f469fb756c32b4e680715
Editorial: Forces in Biology - Cell and Developmental Mechanobiology and Its Implications in Disease
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Externí odkaz:
https://doaj.org/article/9354204a9a7e41bcb34d3a6107ba2c5f
Publikováno v:
Frontiers in Medicine, Vol 5 (2018)
The importance of studying cancer cell invasion is highlighted by the fact that 90% of all cancer-related mortalities are due to metastatic disease. Melanoma metastasis is driven fundamentally by aberrant cell motility within three-dimensional or con
Externí odkaz:
https://doaj.org/article/b9490d90dc4f498f88c096a118c83b69
Autor:
Teodor E. Yordanov, Marco A. E. Martinez, Tyron Esposito, Juliann B. Tefft, Larisa I. Labzin, Samantha J. Stehbens, Alan Rowan, Benjamin M. Hogan, Christopher S. Chen, Jan Lauko, Anne K. Lagendijk
Cerebral Cavernous Malformations (CCMs) are vascular lesions that predominantly form in blood vessels of the central nervous system (CNS) upon loss of the CCM multimeric protein complex. The endothelial cells (ECs) within CCM lesions are characterise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57617e14dde2d78c2e134afac74b35ed
https://doi.org/10.1101/2023.03.27.534302
https://doi.org/10.1101/2023.03.27.534302