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Akademický článek

Transcriptional coactivator MED15 is required for beta cell maturation

Autor: Alex Z. Kadhim, Ben Vanderkruk, Samantha Mar, Meixia Dan, Katarina Zosel, Eric E. Xu, Rachel J. Spencer, Shugo Sasaki, Xuanjin Cheng, Shannon L. J. Sproul, Thilo Speckmann, Cuilan Nian, Robyn Cullen, Rocky Shi, Dan S. Luciani, Bradford G. Hoffman, Stefan Taubert, Francis C. Lynn

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)

Abstract Mediator, a co-regulator complex required for RNA Polymerase II activity, interacts with tissue-specific transcription factors to regulate development and maintain homeostasis. We observe reduced Mediator subunit MED15 expression in endocrin

Externí odkaz: https://doaj.org/article/a99eab33e6ef46a1bcc1575a5001e336

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Physioxic human cell culture improves viability, metabolism, and mitochondrial morphology while reducing DNA damage

Autor: Brianna D. Guild, James Uniacke, Sara Timpano, Philip J. Medeiros, Gaelan Melanson, Shannon L. J. Sproul, Erin J. Specker

Publikováno v: The FASEB Journal. 33:5716-5728

Multicellular organisms balance oxygen delivery and toxicity by having oxygen pass through several barriers before cellular delivery. In human cell culture, these physiologic barriers are removed, exposing cells to higher oxygen levels. Human cells c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1f263b478fbb2fa094d21ad3003d01d
https://doi.org/10.1096/fj.201802279r

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Practical Application of Ozone: Principles and Case Studies

Ozone is used in three ways: as a biocide, as a classical oxidant, and as a pretreatment for improving the performance of subsequent processes. The ability of ozone to act as a disinfectant and classical oxidant has long been known. Ozone can also be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::60e047457d0b97d2aa54036ce733f2a2
https://doi.org/10.1201/9780203744635-3

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Decontamination technologies for release from bioprocessing facilities. Part VI. Verification of wastewater decontamination

Autor: Otis J. Sproul, G. B. Wickramanayake

Publikováno v: Critical Reviews in Environmental Control. 19:539-555

The purpose of this article is to address issues related to verification of inactivation or removal of microorganisms in waste streams to meet the permissible levels during decontamination processes. The sampling statistics are discussed to identify

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bce3cc36e7ad9c108dc4f91cd9018fad
https://doi.org/10.1080/10643389009388383

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Decontamination technologies for release from bioprocessing facilities. Part I. introduction. Part II. Decontamination of wastewater

Autor: G. B. Wickramanayake, Otis J. Sproul

Publikováno v: Critical Reviews in Environmental Control. 19:359-446

The objective of this study was to assess the current state of knowledge regarding the effectiveness of available technologies to decontaminate or treat the air, equipment surfaces, wastewater, and sludge at the facilities that process biologically a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4d77c732e6e45d0584c3960b13af495b
https://doi.org/10.1080/10643389009388376

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Decontamination technologies for release from bioprocessing facilities. Part IV. Decontamination of equipment/surfaces

Autor: G. B. Wickramanayake, Otis J. Sproul

Publikováno v: Critical Reviews in Environmental Control. 19:481-513

The selection of a method for treatment of surfaces contaminated with rDNA microorganisms or their subcellular components will vary depending upon such factors as the type of surface or the type of equipment to be treated — in addition to consideri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c175a5b40235d39b25e0eaa6315c4295
https://doi.org/10.1080/10643389009388381

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Decontamination technologies for release from bioprocessing facilities. Part III. Decontamination of air

Autor: G. B. Wickramanayake, Otis J. Sproul

Publikováno v: Critical Reviews in Environmental Control. 19:447-463

Sludge generated at rDNA processing facilities consists mainly of biological solids. The processes that have potential applications for decontamination of rDNA sludge include incineration, thermal (dry‐heat and steam) treatment, 7 and electron irra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::88829e35b9add8c23d6708db54f37e2c
https://doi.org/10.1080/10643389009388377

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