Zobrazeno 1 - 10
of 40
pro vyhledávání: '"J. Smyllie"'
Autor:
Andrew P. Patton, Mathew D. Edwards, Nicola J. Smyllie, Ryan Hamnett, Johanna E. Chesham, Marco Brancaccio, Elizabeth S. Maywood, Michael H. Hastings
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Circadian activity modulation in the suprachiasmatic nucleus (SCN) is a network-level emergent property that requires neuropeptide VIP signaling, yet the precise cellular mechanisms are unknown. Patton et al. show that cells expressing VIP or its rec
Externí odkaz:
https://doaj.org/article/ad309a8df6944f3b8e02686e390f2b1d
Autor:
Alex A Koch, James S Bagnall, Nicola J Smyllie, Nicola Begley, Antony D Adamson, Jennifer L Fribourgh, David G Spiller, Qing-Jun Meng, Carrie L Partch, Korbinian Strimmer, Thomas A House, Michael H Hastings, Andrew SI Loudon
Publikováno v:
eLife, Vol 11 (2022)
The mammalian circadian clock exerts control of daily gene expression through cycles of DNA binding. Here, we develop a quantitative model of how a finite pool of BMAL1 protein can regulate thousands of target sites over daily time scales. We used qu
Externí odkaz:
https://doaj.org/article/12909e7319834f59a2d8e05b4469036f
Autor:
Nan Yang, Nicola J Smyllie, Honor Morris, Cátia F Gonçalves, Michal Dudek, Dharshika R J Pathiranage, Johanna E Chesham, Antony Adamson, David G Spiller, Egor Zindy, James Bagnall, Neil Humphreys, Judith Hoyland, Andrew S I Loudon, Michael H Hastings, Qing-Jun Meng
Publikováno v:
PLoS Genetics, Vol 16, Iss 4, p e1008729 (2020)
Evolutionarily conserved circadian clocks generate 24-hour rhythms in physiology and behaviour that adapt organisms to their daily and seasonal environments. In mammals, the suprachiasmatic nucleus (SCN) of the hypothalamus is the principal co-ordina
Externí odkaz:
https://doaj.org/article/43fa25b09c644bd38b2e46c67b3637c5
Publikováno v:
Healthy Ageing and Longevity ISBN: 9783031224676
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb6e9aec88a20eabca8c1bfb3fb721e7
https://doi.org/10.1007/978-3-031-22468-3_2
https://doi.org/10.1007/978-3-031-22468-3_2
Autor:
David McManus, Lenka Polidarova, Nicola J. Smyllie, Andrew P. Patton, Johanna E. Chesham, Elizabeth S. Maywood, Jason W. Chin, Michael H. Hastings
The suprachiasmatic nucleus (SCN) of the hypothalamus is the principal clock driving circadian rhythms of physiology and behavior that adapt mammals to environmental cycles. Disruption of SCN-dependent rhythms compromises health, and so understanding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7a00c6b607904aec50518255f57ddb0
https://www.repository.cam.ac.uk/handle/1810/340378
https://www.repository.cam.ac.uk/handle/1810/340378
Autor:
James S Bagnall, Alex A Koch, Nicola J Smyllie, Nicola Begley, Antony D Adamson, Jennifer L Fribourgh, David G Spiller, Qing-Jun Meng, Carrie L Partch, Korbinian Strimmer, Thomas A House, Michael H Hastings, Andrew SI Loudon
Publikováno v:
Koch, A, Bagnall, J, Smyllie, N J, Begley, N, Adamson, A, Fribourgh, J L, Spiller, D, Meng, Q-J, Partch, C L, Strimmer, K, House, T, Hastings, M H & Loudon, A 2022, ' Quantification of protein abundance and interaction defines a mechanism for operation of the circadian clock ', eLife, vol. 11, e73976 . https://doi.org/10.7554/eLife.73976
The mammalian circadian clock exerts control of daily gene expression through cycles of DNA binding. Here, we develop a quantitative model of how a finite pool of BMAL1 protein can regulate thousands of target sites over daily time scales. We used qu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bda5ec2b702d72fdf720c555831088b1
https://research.manchester.ac.uk/en/publications/238e144d-a42e-4255-b827-1bca6bd15350
https://research.manchester.ac.uk/en/publications/238e144d-a42e-4255-b827-1bca6bd15350
Autor:
James S Bagnall, Alex A Koch, Nicola J Smyllie, Nicola Begley, Antony D Adamson, Jennifer L Fribourgh, David G Spiller, Qing-Jun Meng, Carrie L Partch, Korbinian Strimmer, Thomas A House, Michael H Hastings, Andrew SI Loudon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d655c11a625b7a52ac09ef266b502c35
https://doi.org/10.7554/elife.73976.sa2
https://doi.org/10.7554/elife.73976.sa2
Autor:
Michael H. Hastings, Korbinian Strimmer, Andrew S. I. Loudon, Nicola J. Smyllie, Alex A. Koch, Thomas House, Nicola Begley, Carrie L. Partch, Antony Adamson, David G. Spiller, Qing-Jun Meng, Jennifer L. Fribourgh, James Bagnall
The mammalian circadian clock exerts substantial control of daily gene expression through cycles of DNA binding. Understanding of mechanisms driving the circadian clock is hampered by lack of quantitative data, without which predictive mathematical m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::331ede3812dadd198d35b62e38ea7712
https://doi.org/10.1101/2021.08.27.456017
https://doi.org/10.1101/2021.08.27.456017
Autor:
Johanna E. Chesham, Nicola J. Smyllie, Marco Brancaccio, Mathew D. Edwards, Ryan Hamnett, Andrew P. Patton, Michael H. Hastings, Elizabeth S. Maywood
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
The hypothalamic suprachiasmatic nuclei (SCN) are the principal mammalian circadian timekeeper, co-ordinating organism-wide daily and seasonal rhythms. To achieve this, cell-autonomous circadian timing by the ~20,000 SCN cells is welded into a tight
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b88a126f17493edc39d8f87ddf19f122
http://europepmc.org/articles/PMC7341843
http://europepmc.org/articles/PMC7341843
Autor:
Michael H. Hastings, Johanna E. Chesham, Nan Yang, Honor Morris, Neil E. Humphreys, Judith A. Hoyland, Dharshika Pathiranage, Andrew S. I. Loudon, David G. Spiller, Michal Dudek, Nicola J. Smyllie, Egor Zindy, Antony Adamson, Qing-Jun Meng, James Bagnall, Cátia F. Gonçalves
Publikováno v:
PLoS Genetics, Vol 16, Iss 4, p e1008729 (2020)
PLOS genetics, 16 (4
PLoS Genetics
Yang, N, Smyllie, N J, Morris, H, Gonçalves, C F, Dudek, M, Pathiranage, D R J, Chesham, J E, Adamson, A, Spiller, D G, Zindy, E, Bagnall, J, Humphreys, N, Hoyland, J, Loudon, A S I, Hastings, M H, Meng, Q & Kramer, A (ed.) 2020, ' Quantitative live imaging of Venus::BMAL1 in a mouse model reveals complex dynamics of the master circadian clock regulator ', PLoS Genetics, vol. 16, no. 4, pp. e1008729 . https://doi.org/10.1371/journal.pgen.1008729
PLOS genetics, 16 (4
PLoS Genetics
Yang, N, Smyllie, N J, Morris, H, Gonçalves, C F, Dudek, M, Pathiranage, D R J, Chesham, J E, Adamson, A, Spiller, D G, Zindy, E, Bagnall, J, Humphreys, N, Hoyland, J, Loudon, A S I, Hastings, M H, Meng, Q & Kramer, A (ed.) 2020, ' Quantitative live imaging of Venus::BMAL1 in a mouse model reveals complex dynamics of the master circadian clock regulator ', PLoS Genetics, vol. 16, no. 4, pp. e1008729 . https://doi.org/10.1371/journal.pgen.1008729
Evolutionarily conserved circadian clocks generate 24-hour rhythms in physiology and behaviour that adapt organisms to their daily and seasonal environments. In mammals, the suprachiasmatic nucleus (SCN) of the hypothalamus is the principal co-ordina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08a4c82b2f5f68e1c52340be72ff2921
https://doaj.org/article/43fa25b09c644bd38b2e46c67b3637c5
https://doaj.org/article/43fa25b09c644bd38b2e46c67b3637c5