Zobrazeno 1 - 10
of 84
pro vyhledávání: '"J. Selden"'
Autor:
Harsimran Kaur, Cody N. Heiser, Eliot T. McKinley, Lissa Ventura-Antunes, Coleman R. Harris, Joseph T. Roland, Melissa A. Farrow, Hilary J. Selden, Ellie L. Pingry, John F. Moore, Lauren I. R. Ehrlich, Martha J. Shrubsole, Jeffrey M. Spraggins, Robert J. Coffey, Ken S. Lau, Simon N. Vandekar
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract Spatially resolved molecular assays provide high dimensional genetic, transcriptomic, proteomic, and epigenetic information in situ and at various resolutions. Pairing these data across modalities with histological features enables powerful
Externí odkaz:
https://doaj.org/article/5020e650cae64416958a5b3aac787054
Autor:
Yu Li, Pablo Guaman Tipan, Hilary J Selden, Jayashree Srinivasan, Laura P Hale, Lauren IR Ehrlich
Publikováno v:
eLife, Vol 12 (2023)
Central tolerance ensures autoreactive T cells are eliminated or diverted to the regulatory T cell lineage, thus preventing autoimmunity. To undergo central tolerance, thymocytes must enter the medulla to test their T-cell receptors (TCRs) for autore
Externí odkaz:
https://doaj.org/article/f904cf568a384c8db57d3b896c19a9ae
Autor:
Zicheng Hu, Yu Li, Annemarie Van Nieuwenhuijze, Hilary J. Selden, Angela M. Jarrett, Anna G. Sorace, Thomas E. Yankeelov, Adrian Liston, Lauren I.R. Ehrlich
Publikováno v:
Cell Reports, Vol 21, Iss 1, Pp 168-180 (2017)
Upon recognition of auto-antigens, thymocytes are negatively selected or diverted to a regulatory T cell (Treg) fate. CCR7 is required for negative selection of auto-reactive thymocytes in the thymic medulla. Here, we describe an unanticipated contri
Externí odkaz:
https://doaj.org/article/25d11f79f27b4d3fbca6883e6c7e9b5c
Autor:
Jayashree Srinivasan, Anusha Vasudev, Carolyn Shasha, Hilary J. Selden, Encarnacion Perez, Bonnie LaFleur, Shripad A. Sinari, Andreas Krueger, Ellen R. Richie, Lauren I. R. Ehrlich
Publikováno v:
Aging Cell.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc3501512f550861374a489870f54b9a
https://doi.org/10.1111/acel.13870
https://doi.org/10.1111/acel.13870
Autor:
Sanghee Ki, Daechan Park, Hilary J. Selden, Jun Seita, Haewon Chung, Jonghwan Kim, Vishwanath R. Iyer, Lauren I.R. Ehrlich
Publikováno v:
Cell Reports, Vol 9, Iss 1, Pp 402-415 (2014)
Summary: Age-associated thymic involution results in diminished T cell output and function in aged individuals. However, molecular mediators contributing to the decline in thymic function during early thymic involution remain largely unknown. Here, w
Externí odkaz:
https://doaj.org/article/7300ae8b0df448139fc78d53f96b80f1
Autor:
Yu Li, Pablo Guaman Tipan, Hilary J. Selden, Jayashree Srinivasan, Laura P. Hale, Lauren I.R. Ehrlich
Central tolerance ensures autoreactive T cells are eliminated or diverted to the regulatory T cell lineage, thus preventing autoimmunity. To undergo central tolerance, thymocytes must enter the medulla to test their TCRs for autoreactivity against th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fde6c776c56d7f2927a8090dee8278e1
https://doi.org/10.1101/2022.04.03.486911
https://doi.org/10.1101/2022.04.03.486911
Autor:
Jessica N. Lancaster, Damaris E. Keatinge‐Clay, Jayashree Srinivasan, Yu Li, Hilary J. Selden, Seohee Nam, Ellen R. Richie, Lauren I. R. Ehrlich
Publikováno v:
Aging cell. 21(6)
One of the earliest hallmarks of immune aging is thymus involution, which not only reduces the number of newly generated and exported T cells, but also alters the composition and organization of the thymus microenvironment. Thymic T-cell export conti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a69c98114cc0d649c6f96e4293c0dcee
https://pubmed.ncbi.nlm.nih.gov/35561351
https://pubmed.ncbi.nlm.nih.gov/35561351
Autor:
George Georgiou, Seo Hee Nam, Aram Lyu, Hilary J. Selden, Chang-Han Lee, Wesley H. Godfrey, Lauren I.R. Ehrlich, Adviti Sarang, Todd A. Triplett, Dhivya Arasappan, Terzah M. Horton, Rachel Y. Ames, Zicheng Hu
Publikováno v:
Blood. 136:1837-1850
Despite harboring mutations in oncogenes and tumor suppressors that promote cancer growth, T-cell acute lymphoblastic leukemia (T-ALL) cells require exogenous cells or signals to survive in culture. We previously reported that myeloid cells, particul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b8746cfd2b9313a83ccd0b6e8f4d9e9
https://doi.org/10.1182/blood.2020007145
https://doi.org/10.1182/blood.2020007145
Autor:
Jayashree Srinivasan, Anusha Vasudev, Hilary J. Selden, Encarnacion Perez, Bonnie LaFleur, Shripad A. Sinari, Andreas Krueger, Ellen R. Richie, Lauren I. R. Ehrlich
Age-related thymus involution results in decreased T-cell production, contributing to increased susceptibility to pathogens. Elucidating mechanisms underlying involution will inform strategies to restore thymopoiesis. The thymus is colonized by circu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a8edec147e0db3342c6ea50ddd0f567
https://doi.org/10.1101/2022.01.18.476832
https://doi.org/10.1101/2022.01.18.476832
Autor:
Hilary J. Selden, Anna G. Sorace, Adrian Liston, Lauren I.R. Ehrlich, Annemarie van Nieuwenhuijze, Yu Li, Angela M. Jarrett, Zicheng Hu, Thomas E. Yankeelov
Publikováno v:
Cell Reports, Vol 21, Iss 1, Pp 168-180 (2017)
Upon recognition of auto-antigens, thymocytes are negatively selected or diverted to a regulatory T cell (Treg) fate. CCR7 is required for negative selection of auto-reactive thymocytes in the thymic medulla. Here, we describe an unanticipated contri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::951f646c9fbb691a0eba2fede1e94bd5
https://doi.org/10.1016/j.celrep.2017.09.016
https://doi.org/10.1016/j.celrep.2017.09.016