Zobrazeno 1 - 10
of 31
pro vyhledávání: '"J. Scott Hayes"'
Autor:
J. Scott Hayes, David W. Robertson
Publikováno v:
Cardiovascular Drug Reviews. 5:189-215
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 36:1199-1203
[ 3 H]RU38486 (RU486) was synthesized from its penultimate precursor, desmethyl RU486, by substitution of the secondary amine with tritiated methyl iodide ; specific activity 85 Ci/mmol. Ligand binding studies confirm that RU486 binds with high affin
Publikováno v:
Journal of Cardiovascular Pharmacology. 20:742-749
Autor:
Federico Dies, Ronald B. Franklin, John McNay, Raymond F. Kauffman, J. Scott Hayes, George E. Sandusky, David W. Robertson
Publikováno v:
Cardiovascular Drug Reviews. 8:303-322
Autor:
Raymond F. Kauffman, Virginia L. Wyss, Barbara G. Utterback, J. Scott Hayes, Peter J. Gengo, Nancy Bowling
Publikováno v:
European journal of pharmacology. 187(2)
Effects of prolonged isoproterenol infusion upon the density of cardiac calcium channels, calcium-mediated contractile responses, and the ability of forskolin to enhance tension development and cyclic AMP accumulation were studied in ventricular musc
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 812:313-320
Isoproterenol increased contractility in isolated cat papillary muscles 2-fold with an EC 50 of 6.3·10 -8 M. Nifedipine (3·10 -7 M) reduced contractility in control muscles by 43%; however, inotropic state was restored by isoproterenol with a compa
Publikováno v:
Life Sciences. 31:2519-2527
The effects of insulin and glucagon on CAMP accumulation, protein kinase activation, and glycogenolysis were investigated in isolated rat hepatocytes. Glucagon (0.01 nM to 10 μM) increased the activation state of protein kinase and the rate of gluco
Publikováno v:
Proceedings of the National Academy of Sciences. 76:1570-1574
The relationship between the effects of isoproterenol and prostaglandin E 1 (PGE 1 ) on contractile state, cyclic AMP accumulation, and the activation states of protein kinase (ATP: protein phosphotransferase, EC 2.7.1.37), phosphorylase kinase, glyc
Publikováno v:
Nature. 280:78-80
WE recently reported that PGE1 and isoprenaline have very different effects on the substrates of cyclic AMP-dependent protein kinase that regulate cardiac glycogen metabolism. Both agents elevated the cyclic" AMP content and the protein kinase activi