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Akademický článek

An Abundant and Diverse New Family of Electron Bifurcating Enzymes With a Non-canonical Catalytic Mechanism

Autor: Gerrit J. Schut, Dominik K. Haja, Xiang Feng, Farris L. Poole, Huilin Li, Michael W. W. Adams

Publikováno v: Frontiers in Microbiology, Vol 13 (2022)

Microorganisms utilize electron bifurcating enzymes in metabolic pathways to carry out thermodynamically unfavorable reactions. Bifurcating FeFe-hydrogenases (HydABC) reversibly oxidize NADH (E′∼−280 mV, under physiological conditions) and redu

Externí odkaz: https://doaj.org/article/d80938e3ee074279a9e4c97a386c3003

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Adaptations to high pressure of Nautilia sp. strain PV ‐1, a piezophilic Campylobacterium (aka Epsilonproteobacterium) isolated from a deep‐sea hydrothermal vent

Autor: Francesco Smedile, Dionysis I. Foustoukos, Sushmita Patwardhan, Kelli Mullane, Ian Schlegel, Michael W. Adams, Gerrit J. Schut, Donato Giovannelli, Costantino Vetriani

Publikováno v: Environmental Microbiology. 24:6164-6183

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::076aefa7a761c106cfed4eb7382e5839
https://doi.org/10.1111/1462-2920.16256

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Akademický článek

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Adaptations to high pressure of Nautilia sp. strain PV-1, a piezophilic Campylobacterium (aka Epsilonproteobacterium) isolated from a deep-sea hydrothermal vent

Autor: Francesco, Smedile, Dionysis I, Foustoukos, Sushmita, Patwardhan, Kelli, Mullane, Ian, Schlegel, Michael W, Adams, Gerrit J, Schut, Donato, Giovannelli, Costantino, Vetriani

Publikováno v: Environmental microbiologyREFERENCES.

Physiological and gene expression studies of deep-sea bacteria under pressure conditions similar to those experienced in their natural habitat are critical for understanding growth kinetics and metabolic adaptations to in situ conditions. The Campylo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5132603de480acfa7fba4071d2459233
https://pubmed.ncbi.nlm.nih.gov/36271901

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Obligately aerobic human gut microbe expresses an oxygen resistant tungsten-containing oxidoreductase for detoxifying gut aldehydes

Autor: Michael P. Thorgersen, Gerrit J. Schut, Farris L. Poole, Dominik K. Haja, Saisuki Putumbaka, Harriet I. Mycroft, Willem J. de Vries, Michael W. W. Adams

Publikováno v: Frontiers in microbiology. 13

Brevibacillus massiliensis strain phR is an obligately aerobic microbe that was isolated from human feces. Here, we show that it readily takes up tungsten (W), a metal previously associated only with anaerobes. The W is incorporated into an oxidoredu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f34ac594e26065720500d482dccb3d5
https://pubmed.ncbi.nlm.nih.gov/36051760

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The reductive half-reaction of two bifurcating electron-transferring flavoproteins: Evidence for changes in flavin reduction potentials mediated by specific conformational changes

Autor: Wayne, Vigil, Jessica, Tran, Dimitri, Niks, Gerrit J, Schut, Xiaoxuan, Ge, Michael W W, Adams, Russ, Hille

Publikováno v: The Journal of biological chemistry. 298(6)

The EtfAB components of two bifurcating flavoprotein systems, the crotonyl-CoA-dependent NADH:ferredoxin oxidoreductase from the bacterium Megasphaera elsdenii and the menaquinone-dependent NADH:ferredoxin oxidoreductase from the archaeon Pyrobaculum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::950f47abcc08eb0763d83ffebd617f45
https://pubmed.ncbi.nlm.nih.gov/35429498

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Structure and electron transfer pathways of an electron-bifurcating NiFe-hydrogenase

Autor: Xiang Feng, Gerrit J. Schut, Dominik K. Haja, Michael W. W. Adams, Huilin Li

Publikováno v: Science Advances. 8

Electron bifurcation enables thermodynamically unfavorable biochemical reactions. Four groups of bifurcating flavoenzyme are known and three use FAD to bifurcate. FeFe-HydABC hydrogenase represents the fourth group, but its bifurcation site is unknow

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::158aef2c001753cf69cd491d136c7f91
https://doi.org/10.1126/sciadv.abm7546

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CCG•CGG interruptions in high‐penetrance SCA8 families increase RAN translation and protein toxicity

Autor: Christopher M. Gomez, Lawrence J. Schut, Yoshio Ikeda, Lisa E.L. Romano, Tetsuo Ashizawa, Tammy Reid, Lis Hasholt, Tao Zu, Thomas D. Bird, Kaalak Reddy, S Subramony, Barbara A. Perez, J. Andrew Berglund, Laura P.W. Ranum, Jørgen E. Nielsen, Hannah K. Shorrock, Lauren A. Laboissonniere, Monica Banez-Coronel, Alfredo Brusco

Publikováno v: EMBO Molecular Medicine
Perez, B A, Shorrock, H K, Banez-Coronel, M, Zu, T, Romano, L E, Laboissonniere, L A, Reid, T, Ikeda, Y, Reddy, K, Gomez, C M, Bird, T, Ashizawa, T, Schut, L J, Brusco, A, Berglund, J A, Hasholt, L F, Nielsen, J E, Subramony, S H & Ranum, L P 2021, ' CCG•CGG interruptions in high-penetrance SCA8 families increase RAN translation and protein toxicity ', EMBO Molecular Medicine, vol. 13, no. 11, e14095 . https://doi.org/10.15252/emmm.202114095
EMBO Molecular Medicine, Vol 13, Iss 11, Pp n/a-n/a (2021)

Spinocerebellar ataxia type 8 (SCA8), a dominantly inherited neurodegenerative disorder caused by a CTG•CAG expansion, is unusual because most individuals that carry the mutation do not develop ataxia. To understand the variable penetrance of SCA8,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ff48419dc26e4372e10886d7f4906a0
http://europepmc.org/articles/PMC8573593

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