Zobrazeno 1 - 10
of 100
pro vyhledávání: '"J. Schuppler"'
Publikováno v:
Toxicologic pathology. 10(2)
Putative preneoplastic foci (islands) of altered hepatocytes were induced by single doses of initiating hepatocarcinogens and identified by various histochemical and morphological markers. DNA synthesis, measured by 3H-thymidine and autoradiography,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f44237f768dbbf853a4885b2d321ee3f
https://pubmed.ncbi.nlm.nih.gov/28094714
https://pubmed.ncbi.nlm.nih.gov/28094714
Publikováno v:
Toxicology and applied pharmacology. 106(3)
The benzofurane derivative benzbromarone (BBR) previously has led to liver tumor formation after long-term treatment of rats, but no indications of genotoxicity were detected. The present studies were designed to elucidate the mechanism(s) possibly i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e962f23dd989b3964db994e2aae7838c
https://pubmed.ncbi.nlm.nih.gov/1701930
https://pubmed.ncbi.nlm.nih.gov/1701930
Publikováno v:
Carcinogenesis. 5:453-458
Numerous drugs, hormones and environmental pollutants induce liver growth by hypertrophy and/or hyperplasia, and promote preferential growth of putative preneoplastic foci in the liver. In the present study the regression of hyperplasia after cessati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d95b5cb3c305aac4a9f45988fdb3983a
https://doi.org/10.1093/carcin/5.4.453
https://doi.org/10.1093/carcin/5.4.453
Publikováno v:
Research in Experimental Medicine. 165:271-284
In rats a chronic uremic syndrome was induced by 5/6 resection and subsequent irradiation of the kidneys. After 5 weeks 45Ca and 89Sr were injected simultaneously, and the different metabolic handling of the two elements was determined applying an op
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46601907f1a58b74e40eaa62297e6b81
https://doi.org/10.1007/bf01971387
https://doi.org/10.1007/bf01971387
Autor:
M J, Mihatsch, H U, Zollinger, F, Gudat, J, Schuppler, U N, Riede, G, Thiel, F, Brunner, F, Enderlin
Publikováno v:
Pathobiology. 43:219-223
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58c0ab7db62818a32f7fef18b2efbe2d
https://doi.org/10.1159/000162823
https://doi.org/10.1159/000162823
Publikováno v:
Toxicologic Pathology. 10:132-143
In standard two year tumorigenicity studies some gestagens, alone or in combination with an estrogen have been shown to produce proliferative liver lesions (PLL) in rats. Estrogens in general have not produced PLLs; for ethinyl estradiol the situatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d6012feb6323f0275adefd7f4a9c8ec
https://doi.org/10.1177/019262338201000216
https://doi.org/10.1177/019262338201000216
Autor:
W. Parzefall, Marianne Kallenbach, Anneliese Gerhardt, R. Schulte-Hermann, J. Schuppler, Verena Hoffman
Publikováno v:
Chemico-Biological Interactions. 31:287-300
Treatment of female Wistar rats with cyproterone acetate (CPA) leads to considerable enlargement of the liver. The organ content of water, dry mass, protein, RNA, and DNA increased in parallel with the enlargement; only lipid accumulation showed a sl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e229519281fbdbf4d74b77a1cedde38
https://doi.org/10.1016/0009-2797(80)90017-4
https://doi.org/10.1016/0009-2797(80)90017-4
Publikováno v:
Carcinogenesis. 5:149-153
Putative preneoplastic foci of rat liver, so far believed to be deficient in monooxygenases, are shown to contain a cytochrome P450 isoenzyme inducible by phenobarbital. The isoenzyme is also present and appears catalytically active in liver tumors o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d29b53c689805bea672950b8aa56a33a
https://doi.org/10.1093/carcin/5.2.149
https://doi.org/10.1093/carcin/5.2.149
Autor:
I. Timmermann-Trosiener, Wilfried Bursch, H. Berger, J. Schuppler, G. Ohde, Rolf Schulte-Hermann
Publikováno v:
Environmental Health Perspectives
A number of different compounds, including phenobarbital, hypolipidemic drugs such as clofibrate and nafenopin, the sex steroids progesterone, cyproterone acetate, estradiol and mestranol, chlorinated hydrocarbons such as DDT, hexachlorocyclohexane,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99f4e3b9d2af52303bf02b9a0e657415
http://europepmc.org/articles/PMC1569243
http://europepmc.org/articles/PMC1569243
Autor:
J. Schuppler
Publikováno v:
Protoplasma. 68:457-470
Die Injektion von3H-Thymidin und von Kontrollsubstanzen in bebrutete Huhnereier wurde in bezug auf Lokalisation und Zeit untersucht. Die Absterberate der Embryonen wird bei Injektion von3H-Thymidin in das Amnion am starksten erhoht, geringer bei Appl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9935cef9781bb381d04b3a318b84f5e9
https://doi.org/10.1007/bf01293613
https://doi.org/10.1007/bf01293613