Zobrazeno 1 - 10
of 105
pro vyhledávání: '"J. Schimenti"'
Autor:
Priti Singh, Robert Fragoza, Cecilia S. Blengini, Tina N. Tran, Gianno Pannafino, Najla Al-Sweel, Kerry J. Schimenti, Karen Schindler, Eric A. Alani, Haiyuan Yu, John C. Schimenti
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Proper meiotic chromosome segregation requires mismatch repair genes MLH1 and MLH3, of which variants occur in the human population. Here, the authors use computational predictions and yeast assays to select human MLH1/3 variants for modelling in mic
Externí odkaz:
https://doaj.org/article/ea5df12e8dcb4fb3a1ae13ed6a79b628
Autor:
Eric A. Alani, Priti Singh, Haiyuan Yu, Najla Al-Sweel, John C. Schimenti, Karen Schindler, Cecilia S. Blengini, Robert Fragoza, Kerry J. Schimenti, Tina N. Tran, Gianno Pannafino
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Embryonic aneuploidy from mis-segregation of chromosomes during meiosis causes pregnancy loss. Proper disjunction of homologous chromosomes requires the mismatch repair (MMR) genes MLH1 and MLH3, essential in mice for fertility. Variants in these gen
Autor:
Jeremy O Ward, Laura G Reinholdt, William W Motley, Lisa M Niswander, Dekker C Deacon, Laurie B Griffin, Kristofor K Langlais, Vickie L Backus, Kerry J Schimenti, Marilyn J O'Brien, John J Eppig, John C Schimenti
Publikováno v:
PLoS Genetics, Vol 3, Iss 8, p e139 (2007)
Crossing over during meiotic prophase I is required for sexual reproduction in mice and contributes to genome-wide genetic diversity. Here we report on the characterization of an N-ethyl-N-nitrosourea-induced, recessive allele called mei4, which caus
Externí odkaz:
https://doaj.org/article/7b0560d3de224235b846cf2a83a09ae2
Autor:
Laura A Bannister, Roberto J Pezza, Janet R Donaldson, Dirk G de Rooij, Kerry J Schimenti, R Daniel Camerini-Otero, John C Schimenti
Publikováno v:
PLoS Biology, Vol 5, Iss 5, p e105 (2007)
DMC1 is a meiosis-specific homolog of bacterial RecA and eukaryotic RAD51 that can catalyze homologous DNA strand invasion and D-loop formation in vitro. DMC1-deficient mice and yeast are sterile due to defective meiotic recombination and chromosome
Externí odkaz:
https://doaj.org/article/89ca2432a52d48e2b6a7cd5b7213de99
Publikováno v:
Oncogene
Defective DNA replication can result in genomic instability, cancer and developmental defects. To understand the roles of DNA damage response (DDR) genes on carcinogenesis in mutants defective for core DNA replication components, we utilized the Mcm4
Autor:
Suzanne Hartford, Kerry J. Schimenti, Laurie B. Griffin, John C. Schimenti, Sky K. Feuer, Janice K. Pendola, Carl Lessard, Claire A. Bovet, Nancy R. Graham, Jeremy O. Ward
Publikováno v:
Genetics. 194:447-457
Mammalian male fertility relies on complex inter- and intracellular signaling during spermatogenesis. Here we describe three alleles of the widely expressed A-kinase anchoring protein 9 (Akap9) gene, all of which cause gametogenic failure and inferti
Akademický článek
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Autor:
Suzanne Hartford, Kerry J. Schimenti, Dana L. Philipps, John J. Eppig, Shrivatsav Pattabiraman, Fengyun Sun, John C. Schimenti, Mary Ann Handel, Karen Wigglesworth
Publikováno v:
Developmental Biology. 317:72-82
A novel mutation, repro5, was isolated in a forward genetic screen for infertility mutations induced by ENU mutagenesis. Homozygous mutant mice were phenotypically normal but were infertile. Oocytes from mutant females appeared normal, but were sever
Autor:
M. Bellani, Marvin L. Meistrich, J. Schimenti, Toru Nakano, Maria Jasin, Marco Barchi, T de Lange, G. Petukhova, Rafael Daniel Camerini‐Otero, Herbert Braselmann, Scott Keeney, Harry Scherthan, Tej K. Pandita, W. M. Baarends, Bodo Liebe, Albert J. Fornace
Publikováno v:
Experimental Cell Research, 312(19), 3768-3781. Elsevier Inc.
Meiosis pairs and segregates homologous chromosomes and thereby forms haploid germ cells to compensate the genome doubling at fertilization. Homologue pairing in many eukaryotic species depends on formation of DNA double strand breaks (DSBs) during e
Autor:
Jeremy O. Ward, Lawriston A. Wilson, Brian J. Libby, Laura G. Reinholdt, John C. Schimenti, Marilyn J. O'Brien, Suzanne Hartford, Robert J. Munroe, Kerry J. Schimenti, John J. Eppig, Janice K. Pendola
Publikováno v:
Biology of Reproduction. 69:1615-1625
The genetic control of mammalian gametogenesis is inadequately characterized because of a lack of mutations causing infertility. To further the discovery of genes required for mammalian gametogenesis, phenotype-driven screens were performed in mice u