Zobrazeno 1 - 10
of 949
pro vyhledávání: '"J. Schütz"'
Autor:
Ashwathi Puravankara Menon, Helena Villanueva, Daniel Meraviglia-Crivelli, Hisse M. van Santen, Joschka Hellmeier, Angelina Zheleva, Francesca Nonateli, Timo Peters, Tassilo L.A. Wachsmann, Mercedes Hernandez-Rueda, Johannes B. Huppa, Gerhard J. Schütz, Eva Sevcsik, Beatriz Moreno, Fernando Pastor
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 102198- (2024)
The CD3/T cell receptor (TCR) complex is responsible for antigen-specific pathogen recognition by T cells, and initiates the signaling cascade necessary for activation of effector functions. CD3 agonistic antibodies are commonly used to expand T lymp
Externí odkaz:
https://doaj.org/article/6c3ef753dfa94901b0ef2480454cb96e
Advanced Quantification of Receptor–Ligand Interaction Lifetimes via Single-Molecule FRET Microscopy
Autor:
Lukas Schrangl, Vanessa Mühlgrabner, René Platzer, Florian Kellner, Josephine Wieland, Reinhard Obst, José L. Toca-Herrera, Johannes B. Huppa, Gerhard J. Schütz, Janett Göhring
Publikováno v:
Biomolecules, Vol 14, Iss 8, p 1001 (2024)
Receptor–ligand interactions at cell interfaces initiate signaling cascades essential for cellular communication and effector functions. Specifically, T cell receptor (TCR) interactions with pathogen-derived peptides presented by the major histocom
Externí odkaz:
https://doaj.org/article/f6adba3fa60549a596c4b8d1a3fc9875
Autor:
Dino Luethi, Julian Maier, Deborah Rudin, Dániel Szöllősi, Thomas J. F. Angenoorth, Stevan Stankovic, Matthias Schittmayer, Isabella Burger, Jae-Won Yang, Kathrin Jaentsch, Marion Holy, Anand Kant Das, Mario Brameshuber, Gisela Andrea Camacho-Hernandez, Andrea Casiraghi, Amy Hauck Newman, Oliver Kudlacek, Ruth Birner-Gruenberger, Thomas Stockner, Gerhard J. Schütz, Harald H. Sitte
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
Phosphatidylinositol 4,5-bisphosphate (PIP2) directly regulates norepinephrine transporter (NET) dimer stabilization at the plasma membrane. Furthermore, PIP2 interaction with NET affects efflux.
Externí odkaz:
https://doaj.org/article/bf06230a2bde4a6abd1164301e9e14ad
Autor:
Markus Barden, Astrid Holzinger, Lukas Velas, Marianna Mezősi-Csaplár, Árpád Szöőr, György Vereb, Gerhard J. Schütz, Andreas A. Hombach, Hinrich Abken
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
In engineered T cells the CAR is co-expressed along with the physiological TCR/CD3 complex, both utilizing the same downstream signaling machinery for T cell activation. It is unresolved whether CAR-mediated T cell activation depends on the presence
Externí odkaz:
https://doaj.org/article/e06e8704a97446f89d093d4b3e77ab95
Autor:
Janett Göhring, Florian Kellner, Lukas Schrangl, René Platzer, Enrico Klotzsch, Hannes Stockinger, Johannes B. Huppa, Gerhard J. Schütz
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Mechanical forces acting on ligand-engaged T-cell receptors (TCRs) have previously been implicated in T-cell antigen recognition, yet their sensitivity and specificity are still poorly defined. Here, authors report a FRET-based sensor that informs di
Externí odkaz:
https://doaj.org/article/9aaa195dbacc438b8940b42f235fb0e2
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Efficient scanning of tissue that T cells encounter during their migratory life is pivotal to protective adaptive immunity. In fact, T cells can detect even a single antigenic peptide/MHC complex (pMHC) among thousands of structurally similar yet non
Externí odkaz:
https://doaj.org/article/f1ba4d92a052403e9b4a4fc397e205ba
Publikováno v:
Frontiers in Bioinformatics, Vol 2 (2022)
The human mind shows extraordinary capability at recognizing patterns, while at the same time tending to underestimate the natural scope of random processes. Taken together, this easily misleads researchers in judging whether the observed characteris
Externí odkaz:
https://doaj.org/article/6b9a69f8f0444a4f91d0ccc05f651ddd
Autor:
René Platzer, Benedikt K. Rossboth, Magdalena C. Schneider, Eva Sevcsik, Florian Baumgart, Hannes Stockinger, Gerhard J. Schütz, Johannes B. Huppa, Mario Brameshuber
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Determining molecular clustering in Photoactivated Localization Microscopy (PALM) experiments requires knowledge of the blinking properties of the fluorophore to prevent overcounting artefacts. Here the authors develop an experimental and analytical
Externí odkaz:
https://doaj.org/article/d92f7a805d0a4aa697e8c1c2b9ffabca
Autor:
Fabian Hinterer, Magdalena C. Schneider, Simon Hubmer, Montserrat López-Martinez, Philipp Zelger, Alexander Jesacher, Ronny Ramlau, Gerhard J. Schütz
Publikováno v:
PLoS ONE, Vol 17, Iss 2 (2022)
Single molecule localization microscopy (SMLM) has the potential to resolve structural details of biological samples at the nanometer length scale. Compared to room temperature experiments, SMLM performed under cryogenic temperature achieves higher p
Externí odkaz:
https://doaj.org/article/9e52bddbd4284779ac1094446a05e3f2
A workflow for sizing oligomeric biomolecules based on cryo single molecule localization microscopy.
Autor:
Magdalena C Schneider, Roger Telschow, Gwenael Mercier, Montserrat López-Martinez, Otmar Scherzer, Gerhard J Schütz
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0245693 (2021)
Single molecule localization microscopy (SMLM) has enormous potential for resolving subcellular structures below the diffraction limit of light microscopy: Localization precision in the low digit nanometer regime has been shown to be achievable. In o
Externí odkaz:
https://doaj.org/article/96151b32bc9c4722a62ca40806f5f6e1