Zobrazeno 1 - 10
of 354
pro vyhledávání: '"J. Sawynok"'
Publikováno v:
Pain Research and Management, Vol 17, Iss 1, Pp 10-14 (2012)
The prevalence of neuropathic pain approaches 10% in Canada and the United States. Given the aging population and the increasing survival rates following interventions for neuropathic pain, the prevalence of neuropathic pain conditions is expected to
Externí odkaz:
https://doaj.org/article/5a55c6cf39c143e880ffac3f079492f8
Publikováno v:
Pain Research and Management, Vol 17, Iss 1, Pp 10-14 (2012)
The prevalence of neuropathic pain approaches 10% in Canada and the United States. Given the aging population and the increasing survival rates following interventions for neuropathic pain, the prevalence of neuropathic pain conditions is expected to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::310e2c58d225a5600455689970b99f8e
https://doi.org/10.1155/2012/970423
https://doi.org/10.1155/2012/970423
Autor:
J, Sawynok
Publikováno v:
European journal of pain (London, England). 18(4)
Topical analgesics applied locally to skin or to specialized compartments modify pain by actions on sensory nerve endings and/or adjacent cellular elements. With this approach, there are low systemic drug levels, good tolerability and few drug intera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2c2303d61b2d1ec6c2706e5e15d772f1
https://pubmed.ncbi.nlm.nih.gov/24108446
https://pubmed.ncbi.nlm.nih.gov/24108446
Autor:
J, Sawynok
Publikováno v:
Handbook of experimental pharmacology. (177)
Adenosine and ATP, via P1 and P2 receptors respectively, can modulate pain transmission under physiological, inflammatory, and neuropathic pain conditions. Such influences reflect peripheral and central actions and effects on neurons as well as other
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ea77c39bb6daa490e6d81773f2591c7c
https://pubmed.ncbi.nlm.nih.gov/17087128
https://pubmed.ncbi.nlm.nih.gov/17087128
Autor:
J, Sawynok
Publikováno v:
Journal of psychiatryneuroscience : JPN. 26(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::07e8ae5cb9ee69caf91e1e962ba487c4
https://pubmed.ncbi.nlm.nih.gov/11212589
https://pubmed.ncbi.nlm.nih.gov/11212589
Autor:
J. Sawynok
Publikováno v:
Serotoninergic Neurons and 5-HT Receptors in the CNS ISBN: 9783540667155
5-Hydroxytryptamine (5-HT) plays a multifaceted role in the regulation of nociceptive transmission. Complexity arises from actions at multiple sites within the pain transmission system (periphery, spinal cord, supraspinal sites), actions at multiple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79f3cb715820c3f502e6fed63929365b
https://doi.org/10.1007/978-3-642-60921-3_24
https://doi.org/10.1007/978-3-642-60921-3_24
Autor:
J, Sawynok, A, Reid
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 277(2)
Our study examined the effects of neurotoxin-induced lesions to central 5-hydroxytryptamine (5-HT), noradrenaline (NA) and dopamine (DA) systems on antinociception by caffeine in the formalin test and on locomotor stimulation by caffeine. Locomotor a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::26e8482913221091fc763eacfa3da451
https://pubmed.ncbi.nlm.nih.gov/8627541
https://pubmed.ncbi.nlm.nih.gov/8627541
Publikováno v:
European journal of pharmacology. 298(1)
Morphine releases adenosine from the spinal cord and this contributes to spinal antinociception. The present study examined possible interactions between mu- and subclasses of delta-opioid receptors in the release of adenosine. Nanomolar (10(-8), 10(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ee77e59f7221bb19ee65965344e9e081
https://pubmed.ncbi.nlm.nih.gov/8867918
https://pubmed.ncbi.nlm.nih.gov/8867918
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 275(1)
Release of adenosine from the spinal cord contributes to spinal antinociception by morphine. Morphine induces a Ca(++)-dependent release of adenosine from dorsal spinal cord synaptosomes, which is augmented under partially depolarizing conditions. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4e4f8857533e70e8c2c11a7a596140ba
https://pubmed.ncbi.nlm.nih.gov/7562600
https://pubmed.ncbi.nlm.nih.gov/7562600
Autor:
J, Sawynok, T L, Yaksh
Publikováno v:
Pharmacological reviews. 45(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5dd7649cb7edf93ac98d5c7eb6baa6ca
https://pubmed.ncbi.nlm.nih.gov/8475169
https://pubmed.ncbi.nlm.nih.gov/8475169