Zobrazeno 1 - 10
of 5 488
pro vyhledávání: '"J. Sansom"'
Autor:
Johanna Lilja, Jasmin Kaivola, James R. W. Conway, Joni Vuorio, Hanna Parkkola, Pekka Roivas, Michal Dibus, Megan R. Chastney, Taru Varila, Guillaume Jacquemet, Emilia Peuhu, Emily Wang, Ulla Pentikäinen, Itziar Martinez D. Posada, Hellyeh Hamidi, Arafath K. Najumudeen, Owen J. Sansom, Igor L. Barsukov, Daniel Abankwa, Ilpo Vattulainen, Marko Salmi, Johanna Ivaska
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract The KRAS oncogene drives many common and highly fatal malignancies. These include pancreatic, lung, and colorectal cancer, where various activating KRAS mutations have made the development of KRAS inhibitors difficult. Here we identify the s
Externí odkaz:
https://doaj.org/article/aab4a06c715b4e4481e20d3e6037ab7e
Autor:
Reshmi Nair, Tamsin R. M. Lannagan, Rene Jackstadt, Anna Andrusaite, John Cole, Caitlin Boyne, Robert J. B. Nibbs, Owen J. Sansom, Simon Milling
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
Colorectal cancer (CRC) is the third most prevalent cancer worldwide with a high mortality rate (20–30%), especially due to metastasis to adjacent organs. Clinical responses to chemotherapy, radiation, targeted and immunotherapies are limited to a
Externí odkaz:
https://doaj.org/article/990e4b206f444c4f9e950f6acf44d5d0
Autor:
Yuting Lu, Jana Travnickova, Mihaly Badonyi, Florian Rambow, Andrea Coates, Zaid Khan, Jair Marques, Laura C. Murphy, Pablo Garcia-Martinez, Richard Marais, Pakavarin Louphrasitthiphol, Alex H.Y. Chan, Christopher J. Schofield, Alex von Kriegsheim, Joseph A. Marsh, Valeria Pavet, Owen J. Sansom, Robert S. Illingworth, E. Elizabeth Patton
Publikováno v:
Cell Reports, Vol 43, Iss 11, Pp 114927- (2024)
Externí odkaz:
https://doaj.org/article/a0bd1226210f449ba3106f231ea41cf1
Autor:
Kathryn A. F. Pennel, Phimmada Hatthakarnkul, Colin S. Wood, Guang-Yu Lian, Sara S. F. Al-Badran, Jean A. Quinn, Assya Legrini, Jitwadee Inthagard, Peter G. Alexander, Hester van Wyk, Ahmad Kurniawan, Umar Hashmi, Michael A. Gillespie, Megan Mills, Aula Ammar, Jennifer Hay, Ditte Andersen, Colin Nixon, Selma Rebus, David K. Chang, Caroline Kelly, Andrea Harkin, Janet Graham, David Church, Ian Tomlinson, Mark Saunders, Tim Iveson, Tamsin R. M. Lannagan, Rene Jackstadt, Noori Maka, Paul G. Horgan, Campbell S. D. Roxburgh, Owen J. Sansom, Donald C. McMillan, Colin W. Steele, Nigel B. Jamieson, James H. Park, Antonia K. Roseweir, Joanne Edwards
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-20 (2024)
Abstract Colorectal cancer (CRC) is a heterogenous malignancy underpinned by dysregulation of cellular signaling pathways. Previous literature has implicated aberrant JAK/STAT3 signal transduction in the development and progression of solid tumors. I
Externí odkaz:
https://doaj.org/article/3b63169b435447a19a5fb490ee037279
Autor:
Arafath K. Najumudeen, Sigrid K. Fey, Laura M. Millett, Catriona A. Ford, Kathryn Gilroy, Nuray Gunduz, Rachel A. Ridgway, Eve Anderson, Douglas Strathdee, William Clark, Colin Nixon, Jennifer P. Morton, Andrew D. Campbell, Owen J. Sansom
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Oncogenic KRAS mutations are well-described functionally and are known to drive tumorigenesis. Recent reports describe a significant prevalence of KRAS allelic imbalances or gene dosage changes in human cancers, including loss of the wild-ty
Externí odkaz:
https://doaj.org/article/cc435f850ded4ca6b07a54a34129b55d
Autor:
Martin Lightening
C. J. Sansom had always wanted to write novels but he felt he might not have the time or the energy until he retired. When he was forty-eight his father died and left him a small inheritance which allowed him time to try. Dissolution (2003), set in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f46181e6a8576c484d5255955611fb0
https://doi.org/10.1057/978-1-137-31902-9_96
https://doi.org/10.1057/978-1-137-31902-9_96
Publikováno v:
Remote Sensing, Vol 16, Iss 19, p 3743 (2024)
Rivers convey a broad range of materials, such as sediment, nutrients, and contaminants. Much of this transport can occur during or immediately after an episodic, pulsed event like a flood or an oil spill. Understanding the flow processes that influe
Externí odkaz:
https://doaj.org/article/326dd3dca70b4260848f2c3909a1a981
Autor:
Lydia Melissourgou-Syka, Michael A. Gillespie, Sean M. O'Cathail, Owen J. Sansom, Colin W. Steele, Campbell S. D. Roxburgh
Publikováno v:
Journal of Immunotherapy and Precision Oncology, Vol 6, Iss 4, Pp 187-197 (2023)
Colorectal cancer (CRC) is the third most common malignancy across the globe and, despite advances in treatment strategies, survival rates remain low. Rectal cancer (RC) accounts for most of these cases, and traditional management strategies for adva
Externí odkaz:
https://doaj.org/article/8489cce57d0f48d292b136f85aaed0f1
Autor:
Anja L Frei, Anthony McGuigan, Ritik RAK Sinha, Mark A Glaire, Faiz Jabbar, Luciana Gneo, Tijana Tomasevic, Andrea Harkin, Tim J Iveson, Mark Saunders, Karin Oein, Noori Maka, Francesco Pezella, Leticia Campo, Jennifer Hay, Joanne Edwards, Owen J Sansom, Caroline Kelly, Ian Tomlinson, Wanja Kildal, Rachel S Kerr, David J Kerr, Håvard E Danielsen, Enric Domingo, TransSCOT Consortium, David N Church, Viktor H Koelzer
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 9, Iss 6, Pp 449-463 (2023)
Abstract Multiplex immunofluorescence (mIF) imaging can provide comprehensive quantitative and spatial information for multiple immune markers for tumour immunoprofiling. However, application at scale to clinical trial samples sourced from multiple i
Externí odkaz:
https://doaj.org/article/d2fd350d290249e6b38f3b09f966ff54