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5,5-Dimethylthiazolidine-4-carboxylic acid (DTC) as a proline analog with restricted conformation

Autor: John W. Bean, D. Regoli, D. S. Eggleston, J. Samanen, T. Romoff, G. Zuber, M. Saunders, K. Kopple

Publikováno v: International Journal of Peptide and Protein Research. 35:501-509

Spectroscopic evidence is presented for the lack of intramolecular hydrogen bonding in a simple peptide derivative of 5,5-dimethylthiazolidine-4-carboxylic acid (Dtc). The infrared spectrum of Boc-Pro-Ile-OMe 1 in nonpolar solvents displays two N-H s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb82b240fdb3df0a444673642c1c8c50
https://doi.org/10.1111/j.1399-3011.1990.tb00254.x

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Discovery of Orally Active Nonpeptide Vitronectin Receptor Antagonists Based on a 2-Benzazepine Gly-Asp Mimetic

Publikováno v: Journal of Medicinal Chemistry. 43:22-26

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::921ed25c145b5edbd1b8a614916fc7cc
https://doi.org/10.1021/jm990446u

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Chemical Approaches to Improve the Oral Bioavailability of Peptidergic Molecules

Autor: Philip L. Smith, A. Nichols, Thomas W. Ku, William E. Bondinell, Glynn Wilson, J. Samanen, Chao-Pin Lee, Gerald R. Rhodes

Publikováno v: Journal of Pharmacy and Pharmacology. 48:119-135

This review discusses both tools and strategies that may be employed as approaches towards the pursuit of orally active compounds from peptidergic molecules. Besides providing a review of these subjects, this paper provides an example of how these we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5af741b2c0bab50ac96bb650166aff3c
https://doi.org/10.1111/j.2042-7158.1996.tb07111.x

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SYNTHESIS OF A S-4-CARBOXYPHENYLALANINE DERIVATIVE FOR USE IN PEPTIDE SYNTHESIS

Autor: Nambi Aiyar, J. Samanen, Robert G. Franz, Joseph Weinstock, Raul R. Calvo

Publikováno v: Organic Preparations and Procedures International. 26:533-538

(1994). SYNTHESIS OF A S-4-CARBOXYPHENYLALANINE DERIVATIVE FOR USE IN PEPTIDE SYNTHESIS. Organic Preparations and Procedures International: Vol. 26, No. 5, pp. 533-538.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::11da9891362750a6d760bc6d8086b232
https://doi.org/10.1080/00304949409458051

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Refinement of a molecular model of angiotensin II (AII) employed in the discovery of potent nonpeptide antagonists

Autor: Joseph Weinstock, Catherine E. Peishoff, Richard M. Keenan, J. Samanen

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 3:909-914

A novel conformational model of AII, Model II, had been employed previously in the design of potent benzylimidazole AII antagonists (J. Med. Chem. 1991, 34, 1514–1517). This paper considers this model in relation to the recently described potent AI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::30e62e997f538c11f27acc7960c8e74e
https://doi.org/10.1016/s0960-894x(00)80691-5

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Characterization of Bovine Ovary Angiotensin II Receptors Using Subtype-Selective Antagonists

Autor: J. Samanen, Richard M. Edwards, Nambi Aiyar, Ponnal Nambi, Griffin E, Joseph Weinstock

Publikováno v: Pharmacology. 46:1-8

Angiotensin-II (AII) receptors have been classified as AT1 and AT2 subtypes based on selective antagonists. AII binding sites in bovine ovary membranes were characterized using the radiolabeled AII antagonist, [125I]Sar1,Ile8-AII ([125I]SIA). The bin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcd245de5470fedd8656dac6ff8bb4e7
https://doi.org/10.1159/000139022

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