Design of specific inhibitors of quinolinate synthase based on [4Fe-4S] cluster coordination

Autor: J. Saez Cabodevilla, Anne Volbeda, Martin Clémancey, Jean-Marc Latour, Juan-Carlos Fontecilla-Camps, Patricia Amara, S. Ollagnier de Choudens, Claudine Darnault, Océane Gigarel, Olivier Hamelin, Debora Reichmann

Publikováno v: Chemical Communications
Chemical Communications, Royal Society of Chemistry, 2019, 55 (26), pp.3725-3728. ⟨10.1039/c8cc09023h⟩
Chemical Communications, 2019, 55 (26), pp.3725-3728. ⟨10.1039/c8cc09023h⟩

International audience; Quinolinate synthase (NadA) is a [4Fe-4S] cluster-containing enzyme involved in the formation of quinolinic acid, the precursor of the essential NAD coenzyme. Here, we report the synthesis and activity of derivatives of the fi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d577a4e0b4b002faa738856edb5f4c2
https://hal.archives-ouvertes.fr/hal-02091389

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