Zobrazeno 1 - 10
of 101
pro vyhledávání: '"J. S. Rubin"'
Autor:
Derek R. Holman, Samuel J. S. Rubin, Mariusz Ferenc, Elizabeth A. Holman, Alexander N. Koron, Robel Daniel, Brigid S. Boland, Garry P. Nolan, John T. Chang, Stephan Rogalla
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract The utility of spatial omics in leveraging cellular interactions in normal and diseased states for precision medicine is hampered by a lack of strategies for matching disease states with spatial heterogeneity-guided cellular annotations. Her
Externí odkaz:
https://doaj.org/article/9cf3949b48914fbdaf084cb324a67561
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 24, p 17504 (2023)
Human protein kinases are highly-sought-after drug targets, historically harnessed for treating cancer, cardiovascular disease, and an increasing number of autoimmune and inflammatory conditions. Most current treatments involve small molecule protein
Externí odkaz:
https://doaj.org/article/0abe09b6c29349a490490444dfd39ec9
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 24, p 17600 (2023)
Protein kinases are one of the most significant drug targets in the human proteome, historically harnessed for the treatment of cancer, cardiovascular disease, and a growing number of other conditions, including autoimmune and inflammatory processes.
Externí odkaz:
https://doaj.org/article/d1114a38de384e6eac70c68c1b29e192
Publikováno v:
Cancers, Vol 14, Iss 17, p 4236 (2022)
Pancreatic ductal adenocarcinoma (PDAC) is the most common pancreatic tumor and is associated with poor prognosis and treatment response. The tumor microenvironment (TME) is recognized as an important factor in metastatic progression across cancers.
Externí odkaz:
https://doaj.org/article/4b2a36c24830466a9080c4b344988da3
Autor:
Samuel J. S. Rubin, Lawrence Bai, Yeneneh Haileselassie, Gotzone Garay, Chohee Yun, Laren Becker, Sarah E. Streett, Sidhartha R. Sinha, Aida Habtezion
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Distinguishing clinical subtypes of IBD is critical for optimal treatments, outcome prediction, and better understanding of disease pathogenesis. Here the authors phenotype blood and intestinal immune cells by mass cytometry and identify signatures a
Externí odkaz:
https://doaj.org/article/9a229a7519d7425b9121ac0a514fa771
Autor:
Se Eun Ha, Brian G. Jorgensen, Lai Wei, Byungchang Jin, Min-Seob Kim, Sandra M. Poudrier, Rajan Singh, Allison Bartlett, Hannah Zogg, Sei Kim, Gain Baek, Masaaki Kurahashi, Moon-Young Lee, Yong-Sung Kim, Suck-Chei Choi, Kent C. Sasse, Samuel J. S. Rubin, Andres Gottfried-Blackmore, Laren Becker, Aida Habtezion, Kenton M. Sanders, Seungil Ro
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 9, p 5007 (2022)
Metalloendopeptidase ADAM-Like Decysin 1 (ADAMDEC1) is an anti-inflammatory peptidase that is almost exclusively expressed in the gastrointestinal (GI) tract. We have recently found abundant and selective expression of Adamdec1 in colonic mucosal PDG
Externí odkaz:
https://doaj.org/article/3b9d7495f4dc4c43b12f2780e01c2f2a
Publikováno v:
Journal of Clinical and Translational Science, Vol 5 (2021)
Abstract Introduction: There is significant interest in the use of angiotensin converting enzyme inhibitors (ACE-I) and angiotensin II receptor blockers (ARB) in coronavirus disease 2019 (COVID-19) and concern over potential adverse effects since th
Externí odkaz:
https://doaj.org/article/8e764b7d47254a0e85a3a1a8fc8b9a3f
Publikováno v:
Journal of Clinical and Translational Science, Vol 5 (2021)
Given the rapidly progressing coronavirus disease 2019 (COVID-19) pandemic, this report on a US cohort of 54 COVID-19 patients from Stanford Hospital and data regarding risk factors for severe disease obtained at initial clinical presentation is high
Externí odkaz:
https://doaj.org/article/d8c079847a8c41019feef2c8016bf911
Autor:
Lawrence Bai, Denis Dermadi, Laurynas Kalesinskas, Mai Dvorak, Sarah E Chang, Ananthakrishnan Ganesan, Samuel J S Rubin, Alex Kuo, Peggie Cheung, Michele Donato, Paul J Utz, Aida Habtezion, Purvesh Khatri
Publikováno v:
Journal of Crohn's and Colitis. 17:804-815
Background and Aims Current understanding of histone post-translational modifications [histone modifications] across immune cell types in patients with inflammatory bowel disease [IBD] during remission and flare is limited. The present study aimed to
Publikováno v:
World Journal of Clinical Cases. 10:1787-1794
Colitis is a known potential toxicity of immune checkpoint inhibitors (ICIs). Studies evaluating the risk of disease exacerbation following ICI treatment in patients with pre-existing inflammatory bowel disease (IBD) are limited.To assess the clinica