Zobrazeno 1 - 10 of 16 pro vyhledávání: '"J. S. Nixon"'
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T-cell signal transduction and the role of protein kinase C
Autor: J. S. Nixon, S. E. Wilkinson
Publikováno v: Cellular and Molecular Life Sciences CMLS. 54:1122-1144
The T lymphocyte has a vital part to play in maintaining the host response to bacterial and viral infection and also appears to play a key pathological role in autoimmune diseases such as rheumatoid arthritis. In this review, we summarize the signall
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5552e13f8bd0f39aa62b1375d605de07
https://doi.org/10.1007/s000180050241
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3
Design and synthesis of the cartilage protective agent (CPA, Ro32-3555)
Autor: P.J. Malsher, Michael J. Broadhurst, K. M. K. Bottomley, Geoffrey Lawton, Brown Paul Anthony, M.I. Cooper, J. S. Nixon, Ian Reginald Kilford, Neera Borkakoti, William Henry Johnson, N. Ballantyne, A.J. Eatherton, B.M. Sutton, E. J. Lewis
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 7:2299-2302
A novel series of MMP inhibitors has been identified. The compounds are potent selective inhibitors of collagenase with good solubility and oral bioavailability. One compound, designated Ro32-3555, has been selected for development as a cartilage pro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2abba5802c7d4c274e7e5bc1f9ae53df
https://doi.org/10.1016/s0960-894x(97)00416-2
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4
Ro 32-3555, an orally active collagenase inhibitor, prevents cartilage breakdownin vitroandin vivo
Autor: J. Bishop, M. Brewster, J. M. Budd, David Bradshaw, F. Rose, Brown Paul Anthony, William Henry Johnson, K. M. K. Bottomley, Michael J. Broadhurst, K. Wilson, J. S. Nixon, B.M. Sutton, A. Greenham, L H Elliott, E. J. Lewis
Publikováno v: British Journal of Pharmacology. 121:540-546
1. Ro 32-3555 (3(R)-(cyclopentylmethyl)-2(R)-[(3,4,4-trimethyl-2,5-dioxo-1- imidazolidinyl)methyl]-4-oxo-4-piperidinobutyrohydroxamic acid) is a potent, competitive inhibitor of human collagenases 1, 2 and 3 (Ki values of 3.0, 4.4 and 3.4 nM, respect
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::04ad879a10078b1561ba51fb5a1f8d7b
https://doi.org/10.1038/sj.bjp.0701150
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5
Inhibition of bovine nasal cartilage degradation by selective matrix metalloproteinase inhibitors
Autor: Hans Werner Lahm, Pat Eyers, Brown Paul Anthony, Michael J. Broadhurst, L H Elliott, John M. Budd, Trevor J. Hallam, Urs Röthlisberger, David Bradshaw, Geoffrey Lawton, Amanda Whittle, J. S. Nixon, Maisie James, Hill Christopher Huw, Janet E. Merritt, Neera Borkakoti, William Henry Johnson, Balraj Krishnan Handa, K. M. K. Bottomley
Publikováno v: Biochemical Journal. 323:483-488
N-terminal analysis of aggrecan fragments lost from bovine nasal cartilage cultured in the presence of recombinant human interleukin 1alpha revealed a predominant ARGSVIL sequence with an additional ADLEX sequence. Production of the ARGSVIL-containin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2481197cc0207f066b2fbffa6c53b86
https://doi.org/10.1042/bj3230483
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7
K252a is a potent and selective inhibitor of phosphorylase kinase
Autor: Anthony D. Sedgwick, Peter D. Davis, L H Elliott, Geoffrey Lawton, J. S. Nixon, Sandra E. Wilkinson, Hill Christopher Huw
Publikováno v: Biochemical and Biophysical Research Communications. 171:148-154
The inhibition of phosphorylase kinase by a number of protein kinase inhibitors was examined. Both K252a and staurosporine are potent inhibitors of phosphorylase kinase with IC50 values of 1.7 nM and 0.5 nM respectively. K252a shows a 300-fold select
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf0057ad08f12869bb037721e71211f0
https://doi.org/10.1016/0006-291x(90)91369-4
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8
Ro 32-3555, an orally active collagenase inhibitor, prevents cartilage breakdown in vitro and in vivo
Autor: E J, Lewis, J, Bishop, K M, Bottomley, D, Bradshaw, M, Brewster, M J, Broadhurst, P A, Brown, J M, Budd, L, Elliott, A K, Greenham, W H, Johnson, J S, Nixon, F, Rose, B, Sutton, K, Wilson
Publikováno v: British journal of pharmacology. 121(3)
1. Ro 32-3555 (3(R)-(cyclopentylmethyl)-2(R)-[(3,4,4-trimethyl-2,5-dioxo-1- imidazolidinyl)methyl]-4-oxo-4-piperidinobutyrohydroxamic acid) is a potent, competitive inhibitor of human collagenases 1, 2 and 3 (Ki values of 3.0, 4.4 and 3.4 nM, respect
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::40ec6035c213136ff20675ec5d7a7da5
https://pubmed.ncbi.nlm.nih.gov/9179398
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9
Different sensitivities of neutrophil responses to a selective protein kinase C inhibitor Ro 31-8425; redundancy in signal transduction
Autor: Sandra E. Wilkinson, Janet E. Merritt, J. S. Nixon, John A. Sullivan, Jenny Tse
Publikováno v: Cellular signalling. 9(1)
Previous studies implicating a role for protein kinase C (PKC) in mediating stimulation of cellular responses by physiological agonists have relied on use of non-specific inhibitors or direct stimulation of PKC by phorbol esters. However, much of thi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20de1016667fdcf505610236ce0441b3
https://pubmed.ncbi.nlm.nih.gov/9067630
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10
Novel, potent and selective inhibitors of protein kinase C show oral anti-inflammatory activity
Autor: J S, Nixon, J, Bishop, D, Bradshaw, P D, Davis, C H, Hill, L H, Elliott, H, Kumar, G, Lawton, E J, Lewis, M, Mulqueen
Publikováno v: Drugs under experimental and clinical research. 17(8)
Clarification of the precise role of protein kinase C (PKC) in cellular functional responses has been hampered by a lack of potent, selective inhibitors. The structural lead provided by staurosporine, a potent but non-selective protein kinase (PK) in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2bebf7fae4f69dc40a2b10239e0f4656
https://pubmed.ncbi.nlm.nih.gov/1822831
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