Zobrazeno 1 - 10
of 48
pro vyhledávání: '"J. S. Major"'
Autor:
Christine Marie Paul Lambert, Alan Girdwood, Andrew G. Leach, Catherine Bardelle, Andrew P. Garner, Helen Plant, J. S. Major, Brian Law, Dave Buttar, Kevin Blades, Louise Chapman, Nicola Colclough, Joanne V. Allen, Anthony M. Slater, Alexander G. Dossetter
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:5224-5229
A directed screen of a relatively small number of compounds, selected for kinase ATP pocket binding potential, yielded a novel series of hit compounds (1). Hit explosion on two binding residues identified compounds 27 and 43 as the best leads for an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab71f1ec550cbd864375b3a8152d5481
https://doi.org/10.1016/j.bmcl.2011.07.047
https://doi.org/10.1016/j.bmcl.2011.07.047
Autor:
Gary J. Blanchard, J. S. Major
Publikováno v:
Langmuir. 19:2267-2274
We report on the achievement of differential control over adsorption and desorption kinetics of selected vapor phase molecules at ultrathin polymer bilayer interfaces. We synthesize and deposit maleimide−vinyl ether alternating copolymer layers, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6451d4ba9e45a82b4b7fb08a30b0673a
https://doi.org/10.1021/la026918g
https://doi.org/10.1021/la026918g
Autor:
J. S. Major, Gary J. Blanchard
Publikováno v:
Chemistry of Materials. 14:4320-4327
We report on the growth of interfacial multilayer structures formed from maleimide−vinyl ether alternating copolymers. The thickness and density of these polymer layers can be controlled by adding ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba2db7943c9ad574450d24fe73503971
https://doi.org/10.1021/cm020407y
https://doi.org/10.1021/cm020407y
Autor:
J. S. Major and, Gary J. Blanchard
Publikováno v:
Langmuir. 18:6548-6553
We report on the vapor phase adsorption behavior of selected organic molecules onto/into polymer-modified interfaces. We use maleimide−vinyl ether alternating copolymers in conjunction with layer growth chemistry to modify gold-coated substrates wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::343ff21e936c559336c4129ab170fbf9
https://doi.org/10.1021/la011849b
https://doi.org/10.1021/la011849b
Autor:
Gary J. Blanchard, J. S. Major and
Publikováno v:
Chemistry of Materials. 14:2574-2581
We report a strategy for the covalent assembly of polymer multilayers at interfaces, where growth is accomplished one layer at a time. The individual layer constituents are maleimide−vinyl ether alternating copolymers with side groups that possess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdde24f246476d1abda3b738b4059e21
https://doi.org/10.1021/cm011644o
https://doi.org/10.1021/cm011644o
Autor:
Gary J. Blanchard, J. S. Major and
Publikováno v:
Chemistry of Materials. 14:2567-2573
We describe the synthesis and characterization of several maleimide−vinyl ether and maleimide−primary alkene alternating copolymers capable of being incorporated into covalently bound multilayer assemblies. Synthetic control over the monomer subs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eee62fa2d388ecf3d5782352ffde86d7
https://doi.org/10.1021/cm011643w
https://doi.org/10.1021/cm011643w
Publikováno v:
Journal of Materials Chemistry. 11:2996-3001
We have grown layered assemblies of poly[4-(N-maleimido)azobenzene-co-diisopropyl (2-vinyloxy)ethylphosphonate], (poly(MAB-VEP)), where interlayer connections are made using zirconium bisphosphonate (ZP) ionic complexation chemistry. The linear optic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a452560dfac6dd4108bc3c625d859b7f
https://doi.org/10.1039/b103251h
https://doi.org/10.1039/b103251h
Autor:
J. S. Major and, Gary J. Blanchard
Publikováno v:
Langmuir. 17:1163-1168
We report on the design, synthesis, and characterization of a polymeric multilayer assembly that can act as an efficient sorbent for selected metal ions. We use a covalent layer-by-layer deposition scheme for the construction of multilayer assemblies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e29e2c650c9bc1ba621d1b616921d3e
https://doi.org/10.1021/la0013953
https://doi.org/10.1021/la0013953
Autor:
J. S. Major
Publikováno v:
Journal of Receptors and Signal Transduction. 15:595-607
Excessive or inappropriate activation of cell surface receptors can mediate the development of disease. Receptors, therefore, are a focus for drug discovery activities. Empirical screening is important in the search for novel compounds acting at rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32752b2a5bbb91a6ecd2593d8a61fc60
https://doi.org/10.3109/10799899509045242
https://doi.org/10.3109/10799899509045242
Autor:
A.A. Oldham, R.J. Pearce, Robert Hugh Bradbury, M.P. Edwards, M.L. Patel, J.A. Girdwood, John Revill, J. S. Major, Eric Fisher, A.H. Ratcliffe
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:139-144
The synthesis and biological activities of novel 3-substituted 4-amino-2,6-dialkylpyridine derivatives are described. Compounds from this series have potent in vitro and in vivo angiotensin II antagonists activity, including good activity when dosed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2d917ee19feb80e4a77198d3df9e760
https://doi.org/10.1016/s0960-894x(01)81136-7
https://doi.org/10.1016/s0960-894x(01)81136-7