Výsledky vyhledávání

Internal globus pallidotomy in dystonia secondary to Huntington's disease

Autor: E, Cubo, K M, Shannon, R D, Penn, J S, Kroin

Publikováno v: Movement disorders : official journal of the Movement Disorder Society. 15(6)

The prototypic motor feature of Huntington's disease (HD) is chorea, but parkinsonism and involuntary movements such as dystonia and myoclonus can also be present. Pallidotomy has been shown to be an effective treatment for medically refractory Parki

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2629dfa8d0ee673c1b9ab837d6fdeb8d
https://pubmed.ncbi.nlm.nih.gov/11104214

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Chronic intrathecal administration of dexamethasone sodium phosphate: pharmacokinetics and neurotoxicity in an animal model

Autor: J S, Kroin, R B, Schaefer, R D, Penn

Publikováno v: Neurosurgery. 46(1)

Although corticosteroids have been used intraspinally for many years, long-term intrathecal administration has not been examined. We have assessed the stability, bioavailability, and safety of continuously delivering the prodrug dexamethasone sodium

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::00986e09b1b90f90b9a1cf3e7ddebad1
https://pubmed.ncbi.nlm.nih.gov/10626948

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Liquid chromatography/nuclear magnetic resonance spectroscopy and liquid chromatography/mass spectrometry identification of novel metabolites of the multidrug resistance modulator LY335979 in rat bile and human liver microsomal incubations

Autor: W J, Ehlhardt, J M, Woodland, T M, Baughman, M, Vandenbranden, S A, Wrighton, J S, Kroin, B H, Norman, S R, Maple

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 26(1)

Compound LY335979 is a P-glycoprotein inhibitor currently entering phase I clinical trials for potential reversal of multidrug resistance to cancer chemotherapy. In early exploratory studies, LY335979 was found to be rapidly transformed in incubation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::81df0d2d7716b095cf14b88486285449
https://pubmed.ncbi.nlm.nih.gov/9443851

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Effects of intrathecal nonnarcotic analgesics on chronic tactile allodynia in rats: alpha 2-agonists versus somatostatin analog

Autor: N, Ono, J S, Kroin, R D, Penn, J A, Paice

Publikováno v: Neurologia medico-chirurgica. 37(1)

The effects of the intrathecal alpha 2-agonists tizanidine and clonidine and the somatostatin analog octreotide on an experimental rat model of tactile allodynia were investigated to determine the therapeutic potential for treating chronic neuropathi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::99dd4ef994e6bc4aaa39ab734c8873d8
https://pubmed.ncbi.nlm.nih.gov/9046798

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Retrograde transport of brain-derived neurotrophic factor (BDNF) following infusion in neo- and limbic cortex in rat: relationship to BDNF mRNA expressing neurons

Autor: T, Sobreviela, M, Pagcatipunan, J S, Kroin, E J, Mufson

Publikováno v: The Journal of comparative neurology. 375(3)

Brain-derived neurotrophic factor (BDNF) was the second member of the nerve growth factor (NGF) family to be isolated. The ability of BDNF to be retrogradely transported following intraparenchymal infusion represents a unique neurobiological tool to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::603358fda8d9ec52ff3b7ceebc673166
https://pubmed.ncbi.nlm.nih.gov/8915840

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Synthesis and Biological Activity of 2',2'-Difluorodeoxycytidine (Gemcitabine)

Autor: L. W. Hertel, J. S. Kroin, C. S. Grossman, Gerald B. Grindey, A. F. Dorr, A. M. V. Storniolo, W. Plunkett, V. Gandhi, P. Huang

Publikováno v: ACS Symposium Series ISBN: 9780841234420

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fe7ca1bf8193ffbcbb54450fc1c52255
https://doi.org/10.1021/bk-1996-0639.ch019

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Effect of a template-located 2',2'-difluorodeoxycytidine on the kinetics and fidelity of base insertion by Klenow (3'--5'exonuclease-) fragment

Autor: W E, Schy, L W, Hertel, J S, Kroin, L B, Bloom, M F, Goodman, F C, Richardson

Publikováno v: Cancer research. 53(19)

Gemcitabine [2',2'-difluorodeoxycytidine (dFdCyd)], a potent antitumor agent, inhibits DNA synthesis and is incorporated internally into DNA. The effect of a template-incorporated dFdCyd molecule (dFdCyd-) on DNA polymerase function was examined. Two

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b7da9d6afc166bc3f22d20f74c0aad41
https://pubmed.ncbi.nlm.nih.gov/8402631

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The distribution of medication along the spinal canal after chronic intrathecal administration

Autor: J S, Kroin, A, Ali, M, York, R D, Penn

Publikováno v: Neurosurgery. 33(2)

Chronic intrathecal drug infusion for the treatment of neurological diseases, such as spasticity and chronic pain, has become an accepted method of therapy in recent years. Concurrent pharmacokinetic studies have shown that the cisternal cerebrospina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1651cea4747399b14fbea894120af05d
https://pubmed.ncbi.nlm.nih.gov/7690122

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Effects of 2',2'-difluorodeoxycytidine (Gemcitabine) on wild type and variant mouse leukemia L1210 cells

Autor: A H, Cory, L W, Hertel, J S, Kroin, J G, Cory

Publikováno v: Oncology research. 5(2)

2',2'-Difluorodeoxycytidine (Gemcitabine, dFdCyd) is a cytotoxic agent which is active toward a variety of tumor cells. It has been shown that there are multiple intracellular sites of action which include ribonucleotide reductase and DNA polymerase.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::94f986ea0526c092e95b0ec35a308197
https://pubmed.ncbi.nlm.nih.gov/8364254

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