Výsledky vyhledávání - "J. S. Haskill"

Expression and localization of IL‐1β mRNA is interrelated with cytoskeletal rearrangement in monocytes stimulated by adherence: A light microscopyin situhybridization study

Autor: M. V. Singer, J. S. Haskill, Ryan Balfour Sartor, Joanna M. Watson, John S. Morris, O I Sirenko, Ulrich Böcker

Publikováno v: Immunology & Cell Biology. 79:444-453

Top of pageAbstract Differences in IL-1 mRNA expression, stability and translation between non-adherent monocytes and those stimulated by adherence suggest that cytokine regulation is coupled to the function and assembly of cytoskeletal structures. I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fb6204a6b7c681239f8b8dbb2f9c93e
https://doi.org/10.1046/j.1440-1711.2001.01031.x

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NF-κB as a target for anti-inflammatory gene therapy: suppression of inflammatory responses in monocytic and stromal cells by stable gene transfer of IκBα cDNA

Autor: K Mondal, Clifford A. Rinehart, J. S. Haskill, John C. Olsen, Sergei S. Makarov, Joanna M. Watson, WN Johnston

Publikováno v: Gene Therapy. 4:846-852

One of the most challenging issues of anti-inflammatory gene therapy is the complexity of inflammatory pathways. Transcription factor NF-kappa B plays a pivotal role in activation of multiple inflammatory molecules, and therefore represents the logic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c30dbe0c5f81e64ba4b4240efa0a1aea
https://doi.org/10.1038/sj.gt.3300461

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Adhesion-Dependent Regulation of an A+U-Rich Element-Binding Activity Associated with AUF1

Autor: J. S. Haskill, John S. Morris, C T DeMaria, O I Sirenko, G Brewer, A K Lofquist

Publikováno v: Molecular and Cellular Biology. 17:3898-3906

Monocyte adherence results in the rapid transcriptional activation and mRNA stabilization of numerous mediators of inflammation and tissue repair. While the enhancer and promoter elements associated with transcriptional activation have been studied,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1617eff0411d897447d2465285400abc
https://doi.org/10.1128/mcb.17.7.3898

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The intracellular IL-1 receptor antagonist alters IL-1-inducible gene expression without blocking exogenous signaling by IL-1 beta

Autor: J M Watson, A K Lofquist, C A Rinehart, J C Olsen, S S Makarov, D G Kaufman, J S Haskill

Publikováno v: The Journal of Immunology. 155:4467-4475

The epithelium-associated tissue distribution of the intracellular IL-1R antagonist (icIL-1Ra) suggests that it functions as a novel regulatory molecule for IL-1 in somatic tissues. We examined the role of the icIL-1Ra in IL-1 beta-induced responses

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ad598ded134a65ee95dfa5a0a35fd97e
https://doi.org/10.4049/jimmunol.155.9.4467

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Transcription-Independent Turnover of IκBα during Monocyte Adherence: Implications for a Translational Component Regulating IκBα/MAD-3 mRNA Levels

Autor: John S. Morris, J. S. Haskill, Krishna Mondal, A. K. Lofquist

Publikováno v: Molecular and Cellular Biology. 15:1737-1746

We identified I kappa B alpha/MAD-3 as an immediate-early gene in human monocytes that is expressed in response to a variety of signals, including adhesion, lipopolysaccharide, and phorbol myristate acetate. Within 5 min of monocyte adhesion, the lev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c46b50014a169666c4658b71925209c9
https://doi.org/10.1128/mcb.15.3.1737

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Interleukin-1 receptor antagonist in normal and psoriatic epidermis

Autor: John J. Voorhees, J S Haskill, A E Berger, W P Arend, Kevin D. Cooper, Lawrence S. Chan, Gary J. Fisher, Craig Hammerberg

Publikováno v: Journal of Clinical Investigation. 90:571-583

The objective of these studies was to characterize the IL-1 inhibitory activity present in normal and psoriatic epidermis from clinically stable lesions. Fractionation of normal epidermal cytosol on a molecular sizing column failed to reveal the pres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39d069d36f430ef9c3ab49b2ec658761
https://doi.org/10.1172/jci115896

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Differential role of tyrosine phosphorylation in adhesion-induced transcription, mRNA stability, and cytoskeletal organization in human monocytes

Autor: J. S. Haskill, Joanna M. Watson, John S. Morris, Krishna Mondal, A K Lofquist, O I Sirenko

Publikováno v: Journal of leukocyte biology. 67(2)

Monocyte adhesion resulted in rapid tyrosine phosphorylation and subsequent cytokine mRNA induction. The objective of this study was to determine the role of specific tyrosine phosphorylation events, particularly those involving members of the MAP ki

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d54836952357efa34ac9a641981eb0d2
https://pubmed.ncbi.nlm.nih.gov/10670583

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Cisplatin inhibits paclitaxel-induced apoptosis in cisplatin-resistant ovarian cancer cell lines: possible explanation for failure of combination therapy

Autor: P L, Judson, J M, Watson, P A, Gehrig, W C, Fowler, J S, Haskill

Publikováno v: Cancer research. 59(10)

Combination chemotherapy using paclitaxel with a platinum-based regimen is currently the standard first-line therapy for ovarian cancer after surgical cytoreduction. Whereas cisplatin-paclitaxel combination chemotherapy has shown significant efficacy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::38986979c80ac52e4260dff2d66a33b5
https://pubmed.ncbi.nlm.nih.gov/10344753

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A calcium-dependent tyrosine kinase splice variant in human monocytes. Activation by a two-stage process involving adherence and a subsequent intracellular signal

Autor: X, Li, D, Hunter, J, Morris, J S, Haskill, H S, Earp

Publikováno v: The Journal of biological chemistry. 273(16)

Freshly isolated human monocytes do not express p125(FAK) but upon adherence to substrata activate the highly related calcium-dependent tyrosine kinase (CADTK), also known as Pyk2, CAKbeta, RAFTK, and FAK2. The monocyte CADTK was 5 kDa smaller than p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f3517a8614d16085f43dd2d609dafedd
https://pubmed.ncbi.nlm.nih.gov/9545257

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Identification of the structural region of taxol that may be responsible for cytokine gene induction and cytotoxicity in human ovarian cancer cells

Autor: Joanna M. Watson, David G. I. Kingston, Clifford A. Rinehart, Mahendra D. Chordia, Ashok G. Chaudhary, J. S. Haskill

Publikováno v: Cancer chemotherapy and pharmacology. 41(5)

Purpose: Interleukin-8 (IL-8) is a pleiotropic chemokine with both chemoattractant and angiogenic properties. In addition to its cytotoxic effects on ovarian cancer cells, taxol can transcriptionally activate genes such as IL-8 that may play a role i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f0130a1c3d1cdf42c93385ef0bb00da
https://pubmed.ncbi.nlm.nih.gov/9523735

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