Výsledky vyhledávání - "J. S. Gounarides"

Effects of cevoglitazar, a dual PPARα/γ agonist, on ectopic fat deposition in fatty Zucker rats

Autor: Didier Laurent, J. S. Gounarides, Brian R. Boettcher, Jiaping Gao

Publikováno v: Diabetes, Obesity and Metabolism. 11:632-636

AIM By acting as both insulin sensitizers and lipid-lowering agents, dual-acting peroxisome proliferator-activated receptors alpha/gamma (PPARalpha/gamma) agonists may be used to improve glucose tolerance in type 2 diabetic patients without inducing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::391986175a6c7d741973abdf8c948bbe
https://doi.org/10.1111/j.1463-1326.2008.01017.x

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High resolution MAS-NMR in combinatorial chemistry

Autor: M J, Shapiro, J S, Gounarides

Publikováno v: Biotechnology and bioengineering. 71(2)

High-resolution magic angle spinning (hr-MAS) NMR is a powerful tool for characterizing organic reactions on solid support. Because magic angle spinning reduces the line-broadening due to dipolar coupling and variations in bulk magnetic susceptibilit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5c9431476d0eb48dbaeaaf6bc84408f8
https://pubmed.ncbi.nlm.nih.gov/11288068

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Heterologously expressed inner lipoyl domain of dihydrolipoyl acetyltransferase inhibits ATP-dependent inactivation of pyruvate dehydrogenase complex. Identification of important amino acid residues

Autor: J C, Jackson, C C, Vinluan, C J, Dragland, V, Sundararajan, B, Yan, J S, Gounarides, N R, Nirmala, S, Topiol, P, Ramage, J E, Blume, T D, Aicher, P A, Bell, W R, Mann

Publikováno v: The Biochemical journal. 334

The activity of the pyruvate dehydrogenase multienzyme complex (PDC), which catalyses the oxidation of pyruvate to acetyl-CoA within the mitochondrion, is diminished in animal models of diabetes. Studies with purified PDC components have suggested th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0af0331558bdc163ccad75f9b83400da
https://pubmed.ncbi.nlm.nih.gov/9729480

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NMR investigation of cyclo7,10[C7,X9,C10,Nle12] analogues of the alpha-factor from Saccharomyces cerevisiae

Autor: J. S. Gounarides, Jeffrey M. Becker, Chu-Biao Xue, Fred Naider

Publikováno v: Biopolymers. 34(6)

The cyclo7,10[Cys7,Cys10,Nle12], cyclo7,10[Cys7,D-Ala9,Cys10,Nle12], and cyclo7,10[Cys7,L-Ala9,Cys10,Nle12] analogues of the alpha-factor mating pheromone (WHWLQLKPGQPMY) of the yeast Saccharomyces cerevisiae were studied in DMSO/water (80:20) and aq

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf7e110b318762004528a995b3a3cb35
https://pubmed.ncbi.nlm.nih.gov/8025218

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Conformational analysis of [D-Ala9]alpha-factor and [L-Ala9]alpha-factor in solution and in the presence of lipid

Autor: Michelle S. Broido, Fred Naider, J. S. Gounarides, Jeffrey M. Becker

Publikováno v: Biochemistry. 32(3)

The conformations in solution and in the presence of lipid vesicles of [D-Ala9] and [L-Ala9] analogues of the alpha-factor (WHWLQLKPGQPMY) from the yeast Saccharomyces cerevisiae were examined by NMR spectroscopy. Although both peptides are flexible

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fb687a697de37043db04dbf00d00ebf
https://pubmed.ncbi.nlm.nih.gov/8422395

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