Zobrazeno 1 - 10
of 16
pro vyhledávání: '"J. S. Gidda"'
Autor:
Darryle Darwin Schoepp, Buddy E. Cantrell, J. S. Gidda, Dennis M. Zimmerman, J. D. Leander, B G Johnson
Publikováno v:
Journal of Medicinal Chemistry. 37:2262-2265
Structure-activity relationship studies were pursued within N-substituted-trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines in an effort to discover a peripherally selective opioid antagonist with high activity following systemic administration. Alte
Autor:
J. S. Gidda, Buddy E. Cantrell, Darryle Darwin Schoepp, B G Johnson, Dennis M. Zimmerman, J. D. Leander
Publikováno v:
ChemInform. 25
Structure-activity relationship studies were pursued within N-substituted-trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines in an effort to discover a peripherally selective opioid antagonist with high activity following systemic administration. Alte
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 273(2)
Recently discovered serotonin3 (5-HT3) receptor antagonists are potent antiemetics in cytotoxic drug-induced vomiting. The specific site where 5-HT3 receptor antagonists act to abolish emesis is controversial. The major objective of this study was to
LY277359 maleate: a potent and selective 5-HT3 receptor antagonist without gastroprokinetic activity
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 254(1)
Several 5-hydroxytryptamine (5-HT3) receptor antagonists have been described. In addition to 5-HT3 receptor antagonist activity, many of these agents also possess gastroprokinetic activity. In the present report, we identify compound LY277359 maleate
Publikováno v:
The Anatomical Record. 209:125-130
The purpose of the present investigation was to identify and compare cholinergic intramural neurons in the lower esophageal sphincter and esophageal body by histochemical staining for acetylcholinesterase and the enzyme that synthesizes acetylcholine
Autor:
R. K. Goyal, J. S. Gidda
Publikováno v:
Journal of Neurophysiology. 52:1169-1180
Swallow
Autor:
J. P. Buyniski, J. S. Gidda
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 251:G779-G785
This study examined the role of cholinergic mechanisms in esophageal smooth muscle of anesthetized opossums. Swallow-induced motility was recorded manometrically before and after treatment with physostigmine or metoclopramide. At the 5-cm site above
Autor:
M M, Foreman, R W, Fuller, M D, Hynes, J S, Gidda, C L, Nichols, J M, Schaus, E C, Kornfeld, J A, Clemens
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 250(1)
Quinelorane (LY163502) has the endocrine, neurochemical and behavioral profile of a potent and highly selective D2-dopaminergic agonist. The administration of quinelorane produced dose-related decreases in serum prolactin concentration of reserpinize
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 248(1)
The well-documented 5-HT3 receptor antagonists, ICS 205-930 and GR38032F, have been compared with regard to their inhibitory activity at 5-HT3 receptors to another gastrokinetic agent, zacopride. Zacopride and ICS 205-930 showed similar affinity (-lo
Publikováno v:
Journal of neurophysiology. 38(5)
This investigation was undertaken to study the timing properties of low-frequency binaural neurons located in the medulla of kangaroo rat (Dipodomys spectabilis). The results show that the response variables, vector strength (VS) and discharge rate (