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Different effects of inhibitors on the O - and N -demethylation of codeine in human liver microsomes
Publikováno v:
European Journal of Clinical Pharmacology. 52:41-47
Objective: The O- and N-demethylation of codeine is catalysed by CYP2D6 and CYP3A4 respectively. The formation rates of morphine by O-demethylation and norcodeine by N-demethylation were studied in two sets of human liver microsomes. Results: Relativ
Publikováno v:
Acta Anaesthesiologica Scandinavica. 40:177-186
Gastrointestinal side effects still constitute a major drawback in both acute and chronic use of opioids. The exact mechanism behind the gastrointestinal effects is not known, but experimental studies indicate both central and peripheral actions. In
Autor:
E, Berntorp, J, Astermark, F, Baghaei, D, Bergqvist, M, Holmström, B, Ljungberg, A, Norlund, J, Palmblad, P, Petrini, L, Stigendal, J, Säwe
Publikováno v:
Haemophilia : the official journal of the World Federation of Hemophilia. 18(2)
In an ongoing health-technology assessment of haemophilia treatment in Sweden, performed by the governmental agency Dental and Pharmaceutical Benefits Agency (TLV; tandvårds-och lākemedelsförmånsverket), the Swedish Council on Health Technology A
Publikováno v:
European Journal of Clinical Pharmacology. 57:309-311
Objective: To study the prescribing of the antiobesity drug orlistat in relation to the approved indication and its weight-reducing effect in clinical practice during the first 3 months of treatment. Methods: Anonymous postal questionnaire survey to
Autor:
Å, Ortqvist, M, Blennow, R-M, Carlsson, L Å, Hanson, A, Lindberg, L, Lindqvist, M, Magnusson, L, Nilsson, A, Norlund, O, Nyrén, P, Olcén, P, Olin, S-A, Silfverdal, J, Säwe, A, Söderström, B, Trollfors
Publikováno v:
Acta paediatrica (Oslo, Norway : 1992). 99(461)
Publikováno v:
Transplant International. 5:S464-S469
Publikováno v:
European journal of clinical pharmacology. 57(4)
To study the prescribing of the antiobesity drug orlistat in relation to the approved indication and its weight-reducing effect in clinical practice during the first 3 months of treatment.Anonymous postal questionnaire survey to prescribers of orlist
Publikováno v:
Clinical pharmacology and therapeutics. 69(1)
The pharmacokinetic interaction between sirolimus, a macrolide immunosuppressant metabolized by CYP3A4, and the calcium channel blocker diltiazem was studied in 18 healthy subjects. Several clinically important interactions have previously been repor