Zobrazeno 1 - 10
of 12
pro vyhledávání: '"J. Russell Grove"'
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:3382-3385
As part of a program to develop better PTP1B fluorogenic substrates that more closely mimic the functionality found in the natural substrate, we have prepared and evaluated nine novel analogs of 4-methylumbelliferone phosphate (MUP) with a variety of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e32acc80b0974e5c4d7965b7840bdb44
https://doi.org/10.1016/j.bmcl.2008.04.021
https://doi.org/10.1016/j.bmcl.2008.04.021
Autor:
Larry Jang, Xianfeng Li, M. Nuria De Francisco, Steven W. Ferla, J. Russell Grove, Siqun Zhou, Jennifer D. Irvine, Yijun Pan, Caiding Xu, Joy A. Miguel, Natalie Macher, Ashok Bhandari, Christopher P. Holmes, Claire M. Moody, Brian Troy Frederick
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:2719-2724
We have synthesized and evaluated a series of triaryl sulfonamide-based PTP1B inhibitors in which a difluoro-methylenephosphonate group of a potent lead has been replaced by potential bioisosteric replacements. Several mono- or di-charged compounds (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22b2e335bf814e75cabe54aa2bb86c94
https://doi.org/10.1016/j.bmcl.2008.03.007
https://doi.org/10.1016/j.bmcl.2008.03.007
Autor:
Xianfeng Li, Liang Wang, Marc Navre, Christopher P. Holmes, J. Russell Grove, Anna Katrin Szardenings, Larry Jang, Ashok Bhandari, Lihong Shi
Publikováno v:
Tetrahedron Letters. 47:19-22
A new method for the synthesis of functionalized biaryl α-ketophosphonic acids has been developed. The key step involves the use of sodium bromobenzoyl phosphonates to react with polymer-bound boronic acids via microwave-assisted aqueous Suzuki coup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::826d53de9c0552daf693fbeda3410ac8
https://doi.org/10.1016/j.tetlet.2005.10.122
https://doi.org/10.1016/j.tetlet.2005.10.122
Autor:
Jennifer E. Martin, J. Russell Grove, Dinesh V. Patel, Jeffrey P. Northrop, Margaret Reed, Matthew J. Pustelnik, Aftab A. Keval, Charles P. Hart
Publikováno v:
Cellular Signalling. 11:453-464
We cloned and expressed the SH2 domain of human GRB2 as glutathione S-transferase and maltose binding protein fusion proteins. We screened three phagemid-based fd pVIII-protein phage display libraries against SH2 domain fusion proteins. Sequence anal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60e70e086656c453f06216b81dd6d7ab
https://doi.org/10.1016/s0898-6568(99)00017-0
https://doi.org/10.1016/s0898-6568(99)00017-0
Publikováno v:
Scopus-Elsevier
The immunosuppressant rapamycin inhibited proliferation of the H4IIEC hepatoma cell line. Rapamycin, but not its structural analog FK506, also inhibited the basal and insulin-stimulated activity of the p70 ribosomal protein S6 kinase. By contrast, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::695a81b5cc3f49e7e9ca35936f554860
https://doi.org/10.1126/science.1380182
https://doi.org/10.1126/science.1380182
Autor:
J. Russell Grove, Claire M. Moody, Xianfeng Li, Jennifer D. Irvine, Steven W. Ferla, Siqun Zhou, Larry Jang, Joy A. Miguel, Caiding Xu, Brian Troy Frederick, Ashok Bhandari, Yijun Pan, Christopher P. Holmes, Natalie Macher, M. Nuria De Francisco
Publikováno v:
Bioorganicmedicinal chemistry letters. 15(19)
A series of novel sulfonamides containing a single difluoromethylene-phosphonate group were discovered to be potent inhibitors of protein tyrosine phosphatase 1B. Structure–activity relationships around the scaffold were investigated, leading to th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bb846b06d0d8cf78ef9246c0ae0210d
https://pubmed.ncbi.nlm.nih.gov/16046123
https://pubmed.ncbi.nlm.nih.gov/16046123
Publikováno v:
Cell. 21:47-56
We have used a mouse mammary tumor virus (MMTV)-infected rat hepatoma cell line as a model system for studying glucocorticoid action. These cells induce tyrosine aminotransferase and MMTV in response to the synthetic glucocorticoid, dexamethasone. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::704c2d898d9d986e9484e3c3cb91c778
https://doi.org/10.1016/0092-8674(80)90113-0
https://doi.org/10.1016/0092-8674(80)90113-0
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