Zobrazeno 1 - 10
of 275
pro vyhledávání: '"J. Rugg"'
Autor:
Michelle S Balaratnam, Fergus J Rugg-Gunn, Rachel Okin, Freya Powell, Stephen Prior, Panayiota Petrochilos, Dhiren Shivji, Salman Haider, Ali Alim-Marvasti, Arvind Chandratheva, Robert Simister, Charlie Lane, Roberto Macarimban, Diego Kaski, Bal Athwal, Rebecca Liu, Timothy Yates, Sanjeev Rajakulendran, Gerry Christofi, Jeremy Sandford, Alexis Ingram, Katherine Bluston, Caroline Weaver, Oluwaseun Odejide, George Glod, Gulsen Gungor, Edmund Nkrumah, Donal Markey, Gary Hotton, Katie Sidle, Jonathan Kennedy, Lisa Penniall, Helen Plum, Anthony Antoniou, Rakhee Prema, Nadia Jeffries, Carole Walters, Valerie L Stevenson, Malini Drysdale, Sabiha Tasnim, Shahrima Hussain, Lily Mackay, Ryan Baulk, Bianca IIii, David Egan, Adrian Capp, Patricia Turner, Christopher Turner
Publikováno v:
Clinical Medicine, Vol 24, Iss 6, Pp 100234- (2024)
Integrated care systems join up health and care services, so that people have the support they need, in the right place, at the right time. The aims include improving outcomes in healthcare, tackling inequalities in access and enhancing productivity
Externí odkaz:
https://doaj.org/article/944fb01b2de04bde97ad9aca51325398
Autor:
Clara Lopes Novo, Emily V. Wong, Colin Hockings, Chetan Poudel, Eleanor Sheekey, Meike Wiese, Hanneke Okkenhaug, Simon J. Boulton, Srinjan Basu, Simon Walker, Gabriele S. Kaminski Schierle, Geeta J. Narlikar, Peter J. Rugg-Gunn
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Here the authors show satellite transcripts in mouse embryonic stem cells drive HP1α into droplets in vitro and also control HP1α organisation and association with chromatin in vivo. Depleting the satellite transcripts converts heterochromatin into
Externí odkaz:
https://doaj.org/article/9694c15ea6ff49a7afe36d07b4947267
Publikováno v:
Ecology and Evolution, Vol 11, Iss 11, Pp 6913-6926 (2021)
Abstract Although it is common for nestlings to exhibit a strong bias for fledging in the morning, the mechanisms underlying this behavior are not well understood. Avoiding predation risk has been proposed as a likely mechanism by a number of researc
Externí odkaz:
https://doaj.org/article/340de84860c34df39141e2df570d128e
Autor:
Peter Chovanec, Amanda J. Collier, Christel Krueger, Csilla Várnai, Claudia I. Semprich, Stefan Schoenfelder, Anne E. Corcoran, Peter J. Rugg-Gunn
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
The role of transcriptional enhancers and 3D chromatin organisation in coordinating the transition from naive to primed pluripotency remains poorly understood. Here the authors generate a high-resolution atlas of gene regulatory interactions, chromat
Externí odkaz:
https://doaj.org/article/7b14988f9bbd452bb5b113c07a446d36
Autor:
Anna Osnato, Stephanie Brown, Christel Krueger, Simon Andrews, Amanda J Collier, Shota Nakanoh, Mariana Quiroga Londoño, Brandon T Wesley, Daniele Muraro, A Sophie Brumm, Kathy K Niakan, Ludovic Vallier, Daniel Ortmann, Peter J Rugg-Gunn
Publikováno v:
eLife, Vol 10 (2021)
The signalling pathways that maintain primed human pluripotent stem cells (hPSCs) have been well characterised, revealing a critical role for TGFβ/Activin/Nodal signalling. In contrast, the signalling requirements of naïve human pluripotency have n
Externí odkaz:
https://doaj.org/article/477038968eb04a52a24c1167301fe0f5
Autor:
Olga Rosspopoff, Emmanuel Cazottes, Christophe Huret, Agnese Loda, Amanda J Collier, Miguel Casanova, Peter J Rugg-Gunn, Edith Heard, Jean-François Ouimette, Claire Rougeulle
Publikováno v:
Nucleic Acids Research. 51:2177-2194
X chromosome inactivation (XCI) is an essential process, yet it initiates with remarkable diversity in various mammalian species. XIST, the main trigger of XCI, is controlled in the mouse by an interplay of lncRNA genes (LRGs), some of which evolved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b600f985f7fea03dd6b2c2548171a600
https://doi.org/10.1093/nar/gkad029
https://doi.org/10.1093/nar/gkad029
Autor:
Mun-Kit Choy, Biola M. Javierre, Simon G. Williams, Stephanie L. Baross, Yingjuan Liu, Steven W. Wingett, Artur Akbarov, Chris Wallace, Paula Freire-Pritchett, Peter J. Rugg-Gunn, Mikhail Spivakov, Peter Fraser, Bernard D. Keavney
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Human embryonic stem cell-derived cardiomyocytes (hESC-CM) are a widely used model to study cardiac genomics. Here, Choy et al. perform promoter capture Hi-C to map long-range chromosomal interactions of hESC-CMs and to study overlap of such regions
Externí odkaz:
https://doaj.org/article/83ebcba231fa46148d8363dbe91cb2fe
Autor:
Clara Lopes Novo, Biola-Maria Javierre, Jonathan Cairns, Anne Segonds-Pichon, Steven W. Wingett, Paula Freire-Pritchett, Mayra Furlan-Magaril, Stefan Schoenfelder, Peter Fraser, Peter J. Rugg-Gunn
Publikováno v:
Cell Reports, Vol 22, Iss 10, Pp 2615-2627 (2018)
Summary: Transcriptional enhancers, including super-enhancers (SEs), form physical interactions with promoters to regulate cell-type-specific gene expression. SEs are characterized by high transcription factor occupancy and large domains of active ch
Externí odkaz:
https://doaj.org/article/a9fe24befd3e4a119da1557f07e1eacc
Assessing the Safety of Human Pluripotent Stem Cells and Their Derivatives for Clinical Applications
Autor:
Peter W. Andrews, Uri Ben-David, Nissim Benvenisty, Peter Coffey, Kevin Eggan, Barbara B. Knowles, Andras Nagy, Martin Pera, Benjamin Reubinoff, Peter J. Rugg-Gunn, Glyn N. Stacey
Publikováno v:
Stem Cell Reports, Vol 9, Iss 1, Pp 1-4 (2017)
Pluripotent stem cells may acquire genetic and epigenetic variants during culture following their derivation. At a conference organized by the International Stem Cell Initiative, and held at The Jackson Laboratory, Bar Harbor, Maine, October 2016, pa
Externí odkaz:
https://doaj.org/article/b5251a18ddb241f29499514e11c852b2
Autor:
Dick W. Zijlmans, Irene Talon, Sigrid Verhelst, Adam Bendall, Karlien Van Nerum, Alok Javali, Andrew A. Malcolm, Sam S. F. A. van Knippenberg, Laura Biggins, San Kit To, Adrian Janiszewski, Danielle Admiraal, Ruth Knops, Nikky Corthout, Bradley P. Balaton, Grigorios Georgolopoulos, Amitesh Panda, Natarajan V. Bhanu, Amanda J. Collier, Charlene Fabian, Ryan N. Allsop, Joel Chappell, Thi Xuan Ai Pham, Michael Oberhuemer, Cankat Ertekin, Lotte Vanheer, Paraskevi Athanasouli, Frederic Lluis, Dieter Deforce, Joop H. Jansen, Benjamin A. Garcia, Michiel Vermeulen, Nicolas Rivron, Maarten Dhaenens, Hendrik Marks, Peter J. Rugg-Gunn, Vincent Pasque
Publikováno v:
Nature Cell Biology, 24, pp. 858-871
Nature Cell Biology, 24, 858-871
Nature Cell Biology
NATURE CELL BIOLOGY
Nature Cell Biology, 24, 858-871
Nature Cell Biology
NATURE CELL BIOLOGY
Funder: The Marks lab is supported by an NWO-XS grant
Funder: M.V. is part of the Oncode Institute, which is partly funded by the Dutch Cancer Society
Funder: D.W.Z. is part of the Oncode Institute, which is partly funded by the Dutch Cance
Funder: M.V. is part of the Oncode Institute, which is partly funded by the Dutch Cancer Society
Funder: D.W.Z. is part of the Oncode Institute, which is partly funded by the Dutch Cance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::384bde611e7af191bfec5692d05cf021
https://doi.org/10.1038/s41556-022-00932-w
https://doi.org/10.1038/s41556-022-00932-w