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Akademický článek

Ex vivo cultures combined with vivo-morpholino induced gene knockdown provide a system to assess the role of WT1 and GATA4 during gonad differentiation.

Autor: Lucas J Rudigier, Christof Dame, Holger Scholz, Karin M Kirschner

Publikováno v: PLoS ONE, Vol 12, Iss 4, p e0176296 (2017)

Gonad morphogenesis relies on the correct spatiotemporal expression of a number of genes that together fulfill the differentiation of the bipotential gonad into testes or ovaries. As such, the transcription factors WT1 and GATA4 are pivotal for prope

Externí odkaz: https://doaj.org/article/5720ce3c82924dc8bdac5479f46acffa

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Amine Oxidase Copper-containing 1 (AOC1) Is a Downstream Target Gene of the Wilms Tumor Protein, WT1, during Kidney Development

Autor: Karin M. Kirschner, Julian Braun, Charlotte Louise Justine Jacobi, Holger Scholz, Anja Bondke Persson, Lucas J. Rudigier

Publikováno v: Journal of Biological Chemistry. 289:24452-24462

Amine oxidase copper-containing 1 (AOC1; formerly known as amiloride-binding protein 1) is a secreted glycoprotein that catalyzes the degradation of putrescine and histamine. Polyamines and their diamine precursor putrescine are ubiquitous to all org

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcda067b1e599909fceee18409a03056
https://doi.org/10.1074/jbc.m114.564336

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A dual role of miR-22 in rhabdomyolysis-induced acute kidney injury

Autor: Pontus B. Persson, Karin M. Kirschner, Michael Fähling, Susanne Mathia, Mumtaz Kasim, Kai-Uwe Eckardt, Christian Rosenberger, L. J. Rudigier

Publikováno v: Acta Physiologica. 224:e13102

Aim In acute kidney injury (AKI), regions of the kidney are hypoxic. However, for reasons yet unknown, adaptation to hypoxia through hypoxia-inducible factor (HIF) is limited. Here, we studied miR-22, a potential HIF repressor, in normal kidneys, as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::508792668b24274243c08465fcb2754f
https://doi.org/10.1111/apha.13102

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Replantation peripherer Gliedmaßen: Möglichkeiten und Grenzen

Autor: J. Rudigier, H.-J. Walde

Publikováno v: DMW - Deutsche Medizinische Wochenschrift. 106:1509-1513

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2b5ad0e877ce47419584f6b774761e10
https://doi.org/10.1055/s-2008-1070544

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14 Jahre Erfahrungen mit der zementfreien ESKA-Sprunggelenksendoprothese

Autor: H. Grundei, F. Menzinger, J. Rudigier

Publikováno v: Fuß & Sprunggelenk. 2:65-75

Summary The introduction of the cementless total ankle replacement to treat severe osteoarthritis since the early 1990s showing excellent results has reduced the indication of arthrodesis. In our hospital the fusion of the talocrural joint is now onl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::96e84fc5f298b4e7d0331d9ea8fa5234
https://doi.org/10.1007/s10302-004-0088-2

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Transcriptional regulation by the Wilms tumor protein, Wt1, suggests a role of the metalloproteinase Adamts16 in murine genitourinary development

Autor: Karin M. Kirschner, Charlotte Louise Justine Jacobi, Holger Scholz, Lucas J. Rudigier

ADAMTS16 (a disintegrin and metalloproteinase with thrombospondin motifs) is a secreted mammalian metalloproteinase with unknown function. We report here that murine Adamts16 is co-expressed with the Wilms tumor protein, Wt1, in the developing glomer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ecef6f911a01dd9cf1ec4f2cefb2d8a
https://europepmc.org/articles/PMC4036291/

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Sprunggelenk

Autor: J. Rudigier

Publikováno v: Ossäre Integration ISBN: 9783540227212

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5de95f6a1e5ff8ecd3be2e0b77aaca60
https://doi.org/10.1007/978-3-540-35687-5_20

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[Denervation of finger joints as an alternative procedure to arthrodesis or endoprosthesis]

Autor: J. Rudigier, R. Merk

Publikováno v: Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Mikrochirurgie der Peripheren Nerven und Gefasse : Organ der V.... 34(3)

Since 1995, we have performed a modified Wilhelm's denervation in case of painful osteoarthrosis of the digital joints. We interviewed 50 patients after an average time of 33.7 months (11 to 68) after surgery to review surgical results. We found good

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e51c159459bf77125c3de9f7566ee4a1
https://pubmed.ncbi.nlm.nih.gov/12494387

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