The Relationship Between the Present‐Day Seasonal Cycles of Clouds in the Mid‐Latitudes and Cloud‐Radiative Feedback

Autor: K. Furtado, Y. Tsushima, P. R. Field, J. Rostron, D. Sexton

Publikováno v: Geophysical Research Letters, Vol 50, Iss 15, Pp n/a-n/a (2023)

Abstract We show that the seasonal cycles of clouds over the mid‐latitude oceans in the Northern Hemisphere are predictors of the responses of clouds to increasing sea‐surface temperatures globally. These regions are therefore “natural laborato

Externí odkaz: https://doaj.org/article/f60646bab3894fba8d9c05499505795a

A human model of bilateral pulmonary vein sampling to assess the effects of one-lung ventilation on neutrophil function.

Autor: Wendy Funston, Marie-Hélène Ruchaud-Sparagano, Jonathan Scott, Jason Powell, Faye A H Cooles, Lauren Shelmerdine, Cliona McDowell, Denis O'Leary, Karen L Booth, Stephen C Clark, Simon J Ledingham, Anthony J Rostron, John H Dark, A John Simpson

Publikováno v: PLoS ONE, Vol 17, Iss 7, p e0271958 (2022)

BackgroundNeutrophil activation drives lung complications after cardiopulmonary bypass (CPB). Evidence suggests the healthy, ventilated lung may beneficially re-condition pro-inflammatory neutrophils. However, evidence in humans is lacking, due to a

Externí odkaz: https://doaj.org/article/2aa19e5197294224bd7a878b503c8168

Hydrogeochemical Characteristics Refine the Conceptual Model of Groundwater Flow in Wood Buffalo National Park, Canada

Autor: Judit Déri-Takács, Benjamin J. Rostron, Carl Mendoza, Judit Mádl-Szőnyi

Publikováno v: Water, Vol 14, Iss 6, p 965 (2022)

Wood Buffalo National Park (WBNP), the largest national park of Canada, has unique and complex ecosystems that depend on specific water quantity and quality. We characterize groundwaters and surface waters in WBNP by determining their chemical compos

Externí odkaz: https://doaj.org/article/c36805fbb10f476c8182f31384f8869c

Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation

Autor: Ananda S. Mirchandani, Stephen J. Jenkins, Calum C. Bain, Manuel A. Sanchez-Garcia, Hannah Lawson, Patricia Coelho, Fiona Murphy, David M. Griffith, Ailiang Zhang, Tyler Morrison, Tony Ly, Simone Arienti, Pranvera Sadiku, Emily R. Watts, Rebecca. S. Dickinson, Leila Reyes, George Cooper, Sarah Clark, David Lewis, Van Kelly, Christos Spanos, Kathryn M. Musgrave, Liam Delaney, Isla Harper, Jonathan Scott, Nicholas J. Parkinson, Anthony J. Rostron, J. Kenneth Baillie, Sara Clohisey, Clare Pridans, Lara Campana, Philip Starkey Lewis, A. John Simpson, David H. Dockrell, Jürgen Schwarze, Nikhil Hirani, Peter J. Ratcliffe, Christopher W. Pugh, Kamil Kranc, Stuart J. Forbes, Moira K. B. Whyte, Sarah R. Walmsley

Publikováno v: Mirchandani, A S, Jenkins, S J, Bain, C C, Sanchez Garcia, M A, Lawson, H, Coelho, P, Murphy, F, Griffith, D, Zhang, A, Morrison, T, Ly, T, Arienti, S, Sadiku, P, Watts, E R, Dickinson, R, Reyes, L, Cooper, G, Clark, S, Lewis, D, Kelly, V, Spanos, C, Musgrave, K M, Delaney, L, Harper, I, Scott, J, Parkinson, N, Rostron, A J, Baillie, J K, Clohisey, S, Pridans, C, Campana, L, Starkey Lewis, P, Simpson, A J, Dockrell, D H, Schwarze, J, Hirani, N, Ratcliffe, P J, Pugh, C W, Kranc, K, Forbes, S J, Whyte, M K B & Walmsley, S R 2022, ' Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation ', Nature Immunology . https://doi.org/0.1038/s41590-022-01216-z

Hypoxemia is a defining feature of acute respiratory distress syndrome (ARDS), an often-fatal complication of pulmonary or systemic inflammation, yet the resulting tissue hypoxia, and its impact on immune responses, is often neglected. In the present

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09ab39b51379ba91e60afdc26dc1fbd1
https://doi.org/10.1038/s41590-022-01216-z

Exposure of Monocytic Cells to Lipopolysaccharide Induces Coordinated Endotoxin Tolerance, Mitochondrial Biogenesis, Mitophagy, and Antioxidant Defenses

Autor: John D. Widdrington, Aurora Gomez-Duran, Angela Pyle, Marie-Helene Ruchaud-Sparagano, Jonathan Scott, Simon V. Baudouin, Anthony J. Rostron, Penny E. Lovat, Patrick F. Chinnery, A. John Simpson

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

In order to limit the adverse effects of excessive inflammation, anti-inflammatory responses are stimulated at an early stage of an infection, but during sepsis these can lead to deactivation of immune cells including monocytes. In addition, there is

Externí odkaz: https://doaj.org/article/e3d3a40efb8e4b5e9c5d241718315a08