The Brain Image Library: A Community-Contributed Microscopy Resource for Neuroscientists

Autor: Mariah Kenney, Iaroslavna Vasylieva, Greg Hood, Ivan Cao-Berg, Luke Tuite, Rozita Laghaei, Megan C. Smith, Alan M. Watson, Alexander J. Ropelewski

Publikováno v: Scientific Data, Vol 11, Iss 1, Pp 1-11 (2024)

Abstract Advancements in microscopy techniques and computing technologies have enabled researchers to digitally reconstruct brains at micron scale. As a result, community efforts like the BRAIN Initiative Cell Census Network (BICCN) have generated th

Externí odkaz: https://doaj.org/article/35296c1a2825486db21d5e6865fb98e8

In silico analysis of class I adenylate-forming enzymes reveals family and group-specific conservations.

Autor: Louis Clark, Danielle Leatherby, Elizabeth Krilich, Alexander J Ropelewski, John Perozich

Publikováno v: PLoS ONE, Vol 13, Iss 9, p e0203218 (2018)

Luciferases, aryl- and fatty-acyl CoA synthetases, and non-ribosomal peptide synthetase proteins belong to the class I adenylate-forming enzyme superfamily. The reaction catalyzed by the adenylate-forming enzymes is categorized by a two-step process

Externí odkaz: https://doaj.org/article/fcd37408390241d9a0e1e4d33e39e02a

The human body at cellular resolution: the NIH Human Biomolecular Atlas Program

Autor: William J. Greenleaf, Sarah A. Teichmann, Margaret Vella, Ajay Pillai, Aviv Regev, Ananda L. Roy, Kristin E. Burnum-Johnson, Cole Trapnell, Yiing Lin, Marda Jorgensen, Gloria S. Pryhuber, Leslie Gaffney, Ken S. Lau, Kimberly Robasky, Jeffrey M. Spraggins, Chuck McCallum, Stavros Michailidis, Randy Heiland, Orit Rozenblatt-Rosen, Allyson Ricarte, Xin bSun, Kevin J. Otto, Amir Bahmani, Zorina S. Galis, James S. Hagood, Monica Nagendran, Gökcen Eraslan, Robin M. Scibek, Jocelyn Y. Kishi, Jay Mulye, Maria Keays, Griffin M. Weber, Caltech-UW Tmc, Charles Ansong, Nicholas A. Nystrom, Vishal G. Venkataraaman, Vladimir Yu. Kiselev, Ucsd Tmc, Ellen M. Quardokus, Tushar bDesai, Bruce Herr, Engagement Component, James E. Anderson, Shin Lin, Lisel Record, Peter V. Kharchenko, Robert F. dMurphy, Stanford-WashU Tmc, Yu Wang, Jian Ma, Sergio Maffioletti, Sarah Black, Matthew Ruffalo, Salvatore Sechi, John C. Marioni, Ziv Bar-Joseph, Richard M. Caprioli, Stanford Ttd, Garry P. Nolan, Marishka Brown, Elizabeth L. Wilder, Maigan A. Brusko, Peter Chou, Tommaso Biancalani, Christian Martijn Schuerch, Julia Laskin, Richard Conroy, Jonathan C. Silverstein, Paula M. Mabee, Dena Procaccini, Pehr B. Harbury, Michael Snyder, Pothur Srinivas, Jennifer Rood, Dana Jackson, Sanjay Jain, Katy Börner, Visualization HuBMAP Integration, William E. Shirey, Sinem K. Saka, James P. Sluka, Agnes B. Fogo, Isabel Goldaracena, Sushma A. Akoju, Raymond C. Harris, Rahul Satija, Sylvia K. Plevritis, Tim Stuart, Shila Ghazanfar, Peng Yin, Harvard Ttd, Aaron M. Horning, Ed Esplin, Amanda Posgai, Michael J. Clare-Salzler, Raf Van de Plas, Aaron Pawlyk, Guo-Cheng Yuan, Benedict aten, DongHye Ye, Hayan Lee, Eyal Fisher, Jay Shendure, Long Cai, Danielle cGutierrez, Carl Kingsford, Ruben Dries, Sara Ahadi, Paul D. Piehowski, Bernd bBodenmiller, Purdue Ttd, Stephanie A. Nevins, Philip D. Blood, Andrew Butler, W. Christopher Lenhardt, Ying Zhu, Alexander J. Ropelewski, Harry S. Nick, Nathan Heath Patterson, Elizabeth K. Neumann, Anna Hupalowska, Samuel H. Friedman, Clive hWasserfall, Qian Zhu, Mark P. deCaestecker, Leonard E. Cross, Mark A. Atkinson, Paul Macklin, Todd M. Brusko, Eeshit Dhaval Vaishnav, Nils Gehlenborg, Kun Zhang

Publikováno v: Nature

Transformative technologies are enabling the construction of three-dimensional maps of tissues with unprecedented spatial and molecular resolution. Over the next seven years, the NIH Common Fund Human Biomolecular Atlas Program (HuBMAP) intends to de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a760adbbc42a3cb40fdfb6a51c3f81aa
http://europepmc.org/articles/PMC6800388

Strategies for Searching Sequence Databases

Autor: Hugh B. Nicholas, David W. Deerfield, Alexander J. Ropelewski

Publikováno v: BioTechniques, Vol 28, Iss 6, Pp 1174-1191 (2000)

We provide a detailed overview of the choices inherent in performing a sequence database search, including the choice of algorithm, substitution matrix and gap model. Each of these choices has implications that can be described as restrictions on the

Externí odkaz: https://doaj.org/article/4cc47a63e4544b9ab5d50984c1c5143a

MPI-PHYLIP: parallelizing computationally intensive phylogenetic analysis routines for the analysis of large protein families.

Autor: Alexander J Ropelewski, Hugh B Nicholas, Ricardo R Gonzalez Mendez

Publikováno v: PLoS ONE, Vol 5, Iss 11, p e13999 (2010)

Phylogenetic study of protein sequences provides unique and valuable insights into the molecular and genetic basis of important medical and epidemiological problems as well as insights about the origins and development of physiological features in pr

Externí odkaz: https://doaj.org/article/725716e6756e4a79848a6cfbacac013e