Zobrazeno 1 - 10 of 19 pro vyhledávání: '"J. Rogler"'
1
Heme-FeIII Superoxide, Peroxide and Hydroperoxide Thermodynamic Relationships: FeIII-O2•– Complex H-Atom Abstraction Reactivity
Autor: Kenneth D. Karlin, Edward I. Solomon, Patrick J. Rogler, Hyun Kim, Savita Sharma, Andrew W. Schaefer
Publikováno v: Journal of the American Chemical Society. 142:3104-3116
Establishing redox and thermodynamic relationships between metal-ion-bound O2 and its reduced (and protonated) derivatives is critically important for a full understanding of (bio)chemical processes involving dioxygen processing. Here, a ferric heme
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f564c0c79ff1ed9be5bc34e2d2df4a0b
https://doi.org/10.1021/jacs.9b12571
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3
Ferric Heme Superoxide Reductive Transformations to Ferric Heme (Hydro)Peroxide Species: Spectroscopic Characterization and Thermodynamic Implications for H-atom Transfer (HAT)
Autor: Hyun Kim, Savita Sharma, Andrew W. Schaefer, Patrick J. Rogler, Kenneth D. Karlin, Edward I. Solomon
Publikováno v: Angew Chem Int Ed Engl
A new end-on low-spin ferric heme peroxide, [(P(Im))Fe(III)─(O(2)(2−))](−) (P(Im)-P), and subsequently formed hydroperoxide species, [(P(Im))Fe(III)─(OOH)] (P(Im)-HP) are generated utilizing the iron-porphyrinate P(Im) with its tethered axial
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10f73f744fb11c947f2b84a7e005405c
https://europepmc.org/articles/PMC7920932/
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4
Heme-Fe
Autor: Hyun, Kim, Patrick J, Rogler, Savita K, Sharma, Andrew W, Schaefer, Edward I, Solomon, Kenneth D, Karlin
Publikováno v: J Am Chem Soc
Establishing redox and thermodynamic relationships between metal-ion-bound O(2) and its reduced (and protonated) derivatives is critically important for a full understanding of (bio)chemical processes involving dioxygen processing. Here, a ferric hem
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::04106ef1a339351d73532c8d6f5f7652
https://pubmed.ncbi.nlm.nih.gov/31913628
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5
Synthetic Fe/Cu Complexes: Toward Understanding Heme-Copper Oxidase Structure and Function
Autor: David A. Quist, Patrick J. Rogler, Daniel E. Diaz, Kenneth D. Karlin, Jeffrey Liu, Gayan B. Wijeratne, Suzanne M. Adam
Publikováno v: Chemical Reviews. 118:10840-11022
Heme-copper oxidases (HCOs) are terminal enzymes on the mitochondrial or bacterial respiratory electron transport chain, which utilize a unique heterobinuclear active site to catalyze the 4H(+)/4e(−) reduction of dioxygen to water. This process inv
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f80d725db915be46ffd9f3d379b5965f
https://doi.org/10.1021/acs.chemrev.8b00074
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6
Isocyanide or nitrosyl complexation to hemes with varying tethered axial base ligand donors: synthesis and characterization
Autor: Savita Sharma, Kenneth D. Karlin, Patrick J. Rogler, Maxime A. Siegler, Hyun Kim
Publikováno v: JBIC Journal of Biological Inorganic Chemistry. 21:729-743
A series of ferrous-heme 2,6-dimethylphenyl isocyanide (DIMPI) and ferrous-heme mononitrosyl complexes have been synthesized and characterized. The heme portion of the complexes studied is varied with respect to the nature of the axial ligand, includ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cb9e10a9c71231a0a6545736948e352
https://doi.org/10.1007/s00775-016-1369-4
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7
Reactions of a heme-superoxo complex toward a cuprous chelate and •NO(g):CcOand NOD chemistry
Autor: Savita Sharma, Kenneth D. Karlin, Patrick J. Rogler
Publikováno v: Journal of Porphyrins and Phthalocyanines. 19:352-360
Following up on the characterization of a new (heme) FeIII-superoxide species formed from the cryogenic oxygenation of a ferrous-heme ( PPy) FeII(1) ( PPy= a tetraarylporphyrinate with a covalently tethered pyridine group as a potential axial base),
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c0ce833776cdbf93bd52839a713e4b5
https://doi.org/10.1142/s108842461550025x
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8
Design and synthesis of 3,5-disubstituted boron-containing 1,2,4-oxadiazoles as potential combretastatin A-4 (CA-4) analogs
Autor: Xiang-Ying Tang, Bhaskar C. Das, Patrick J. Rogler, Todd Evans
We have designed and synthesized a small library of 3,5-disubstituted-1,2,4-oxadiazole containing combretastatin A-4 (CA-4) analogs. Our objective is to increase the efficacy of the CA-4 as an anti-tubulin and antimitotic agent by substituting the ci
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93be9979ed46f9d246a087685735389c
https://europepmc.org/articles/PMC3771381/
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9
Design and Synthesis of 3,5-Disubstituted 1,2,4-Oxadiazole Containing Retinoids from a Retinoic Acid Receptor Agonist
Autor: Xiang-Ying Tang, Bhaskar C. Das, Patrick J. Rogler, Sabita Nayak, Todd Evans, Swarnava Sanyal, Seetaram Mohapatra
Publikováno v: Tetrahedron letters. 52(19)
We previously synthesized novel retinoid libraries, and after screening for bioactivity found one compound BT10 that functions as a specific agonist for retinoic acid receptors. This lead compound was further derivatized using SAR and LRD to obtain 3
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a8f43551b6b9d2b325a69b948e6c9e0
https://pubmed.ncbi.nlm.nih.gov/21765558
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