Zobrazeno 1 - 10 of 112 pro vyhledávání: '"J. Robert Manak"'
1
Akademický článek
Downregulation of oxidative stress-mediated glial innate immune response suppresses seizures in a fly epilepsy model
Autor: Krishna M. Nukala, Anthony J. Lilienthal, Shu Hui Lye, Alexander G. Bassuk, Stanislava Chtarbanova, J. Robert Manak
Publikováno v: Cell Reports, Vol 42, Iss 1, Pp 112004- (2023)
Summary: Previous work in our laboratory has shown that mutations in prickle (pk) cause myoclonic-like seizures and ataxia in Drosophila, similar to what is observed in humans carrying mutations in orthologous PRICKLE genes. Here, we show that pk mut
Externí odkaz: https://doaj.org/article/7b3d4ce31289455297677276d5dc0cb7
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2
Akademický článek
p53-mediated neurodegeneration in the absence of the nuclear protein Akirin2
Autor: Stacey L. Peek, Peter J. Bosch, Ethan Bahl, Brianna J. Iverson, Mrutyunjaya Parida, Preeti Bais, J. Robert Manak, Jacob J. Michaelson, Robert W. Burgess, Joshua A. Weiner
Publikováno v: iScience, Vol 25, Iss 2, Pp 103814- (2022)
Summary: Proper gene regulation is critical for both neuronal development and maintenance as the brain matures. We previously demonstrated that Akirin2, an essential nuclear protein that interacts with transcription factors and chromatin remodeling c
Externí odkaz: https://doaj.org/article/940e5ca7dbf344f6b80be4c28e562945
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4
Akademický článek
The Dm-Myb Oncoprotein Contributes to Insulator Function and Stabilizes Repressive H3K27me3 PcG Domains
Autor: Juan F. Santana, Mrutyunjaya Parida, Abby Long, Joshua Wankum, Anthony J. Lilienthal, Krishna M. Nukala, J. Robert Manak
Publikováno v: Cell Reports, Vol 30, Iss 10, Pp 3218-3228.e5 (2020)
Summary: Drosophila Myb (Dm-Myb) encodes a protein that plays a key role in regulation of mitotic phase genes. Here, we further refine its role in the context of a developing tissue as a potentiator of gene expression required for proper RNA polymera
Externí odkaz: https://doaj.org/article/5df3192e221c40ab9fda468c4bcfe991
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5
Akademický článek
Pervasive genetic interactions modulate neurodevelopmental defects of the autism-associated 16p11.2 deletion in Drosophila melanogaster
Autor: Janani Iyer, Mayanglambam Dhruba Singh, Matthew Jensen, Payal Patel, Lucilla Pizzo, Emily Huber, Haley Koerselman, Alexis T. Weiner, Paola Lepanto, Komal Vadodaria, Alexis Kubina, Qingyu Wang, Abigail Talbert, Sneha Yennawar, Jose Badano, J. Robert Manak, Melissa M. Rolls, Arjun Krishnan, Santhosh Girirajan
Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-19 (2018)
The 16p11.2 deletion leads to a range of neurodevelopmental phenotypes, but to date, sequencing studies have not been able to pinpoint individual genes that are causative for the disease on their own. Here, using Drosophila homologs of 14 16p11.2 gen
Externí odkaz: https://doaj.org/article/d7ac17fe1f8f4fac96fe435cdcaaa18c
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7
Akademický článek
DNA copy number variations in children with vesicoureteral reflux and urinary tract infections.
Autor: Dong Liang, Kirk M McHugh, Pat D Brophy, Nader Shaikh, J Robert Manak, Peter Andrews, Inessa Hakker, Zihua Wang, Andrew L Schwaderer, David S Hains
Publikováno v: PLoS ONE, Vol 14, Iss 8, p e0220617 (2019)
Vesicoureteral reflux (VUR) is a complex, heritable disorder. Genome-wide linkage analyses of families affected by VUR have revealed multiple genomic loci linked to VUR. These loci normally harbor a number of genes whose biologically functional varia
Externí odkaz: https://doaj.org/article/abe8a36d8bb7487d9ac0f2115dde8d7d
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9
Akademický článek
Multiculturalism is good for flies, too.
Autor: J Robert Manak
Publikováno v: PLoS Genetics, Vol 14, Iss 7, p e1007480 (2018)
Externí odkaz: https://doaj.org/article/2607e98c1c3e4f228989468f6902c734
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10
Benign-Ex: Delineating Regions of the Human Genome Benign to Copy Number Variation
Autor: Alyssa S. Wetzel, Heather Major, Mrutyunjaya Parida, J. Robert Manak, Benjamin W. Darbro
While copy number variants (CNVs) have been identified as an important cause of rare genetic disorders, they have also been identified in unaffected control populations, making clinical interpretation of these lesions challenging. Discriminating beni
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::97468729b8b02a0e3c1d82d010290b13
https://doi.org/10.1101/2022.10.17.22280252
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