Výsledky vyhledávání - "J. Robert Coleman"

Abstract PD2-04: Preclinical development of CodaLytic™, a codon-modified influenza virus, as a novel virotherapeutic agent for breast cancer immunotherapy

Autor: Marcin Stawowczyk, Yiwen Zhao, Katie Pfeffer, Juliana Tafrova, James Rodriguez, Chen Yang, Nusrat Jahan, Sybil A. Tasker, Steffen Mueller, J. Robert Coleman, Johanna K. Kaufmann

Publikováno v: Cancer Research. 83:PD2-04

Multiple species of oncolytic viruses (OVs) have been shown to modulate the tumor microenvironment (TME) by increasing immune cell infiltration and activating stimulatory immune responses, leading to the induction of a tumor-specific immune response.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::088baa19794622b06bf2217a4a780822
https://doi.org/10.1158/1538-7445.sabcs22-pd2-04

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Akademický článek

Live-attenuated H1N1 influenza vaccine candidate displays potent efficacy in mice and ferrets.

Autor: Charles B Stauft, Chen Yang, J Robert Coleman, David Boltz, Chiahsuan Chin, Anna Kushnir, Steffen Mueller

Publikováno v: PLoS ONE, Vol 14, Iss 10, p e0223784 (2019)

Currently, influenza vaccine manufacturers need to produce 1-5 x 107 PFU of each vaccine strain to fill one dose of the current live-attenuated-influenza-vaccine (LAIV). To make a single dose of inactivated vaccine (15 ug of each hemagglutinin), the

Externí odkaz: https://doaj.org/article/73ad1e00cc2342e1a115bbc7b97ebe66

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Abstract 689: The codon-modified influenza virus CodaLytic™rescues immunostimulatory activity and anti-tumor efficacy in PD-1-refractory tumor models

Autor: Yiwen Zhao, Nusrat Jahan, Marcin Stawowczyk, Katie Pfeffer, Juliana Tafrova, James Rodriguez, Chen Yang, Sybil A. Tasker, Steffen Mueller, J. Robert Coleman, Johanna K. Kaufmann

Publikováno v: Cancer Research. 83:689-689

Multiple oncolytic viruses have been shown to induce various beneficial changes in the tumor microenvironment (TME), which ultimately support induction of anti-tumor immune responses. We have previously demonstrated that CodaLytic, a codon-modified i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f34f438c813fa91796a4614e608dd8e9
https://doi.org/10.1158/1538-7445.am2023-689

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747 CodaLytic™, a novel codon-pair deoptimized influenza virus creates an immune-stimulatory tumor microenvironment leading to monotherapy efficacy in a preclinical model of breast cancer

Autor: Juliana Tafrova, Steffen Mueller, Sybil A. Tasker, J. Robert Coleman, Marcin Stawowczyk, Katie Pfeffer, Charles B. Stauft, Johanna Kaufmann, Anna Kushnir

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)

BackgroundOncolytic viruses (OVs) of multiple species have been demonstrated to induce beneficial changes in the tumor microenvironment (TME), increasing immune cell infiltration and activating stimulatory immune responses, which ultimately support i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba562964dad1b78b6cee1c8783ff8258
https://doaj.org/article/48c486fc5a694640a8100f05390d164c

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584. Phase 1 Placebo-Controlled Trial of COVI-VAC™, an Intranasal, Live Attenuated COVID-19 Vaccine

Autor: Sybil Tasker, Daryl Bendel, Melissa Bevan, Steffen Mueller, Anna Kushnir, Brandon Londt, J Robert Coleman

Publikováno v: Open Forum Infectious Diseases

Background COVI-VACTM is an intra-nasal live-attenuated SARS-COV-2 synthetic viral vaccine being developed for the prevention of COVID-19. COVI-VAC is attenuated through deletion of the furin cleavage site and introduction of 283 silent deoptimizing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ce41586d0bba8c069cc2a9526c7e994
http://europepmc.org/articles/PMC8644858

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