Zobrazeno 1 - 10
of 282
pro vyhledávání: '"J. Rizkallah"'
Autor:
Christopher T. Esapa, R. A. Jeffrey McIlhinney, Adrian J. Waite, Matthew A. Benson, Jasmin Mirzayan, Henriett Piko, Ágnes Herczegfalvi, Rita Horvath, Veronika Karcagi, Maggie C. Walter, Hanns Lochmüller, Pierre J. Rizkallah, Qi L. Lu, Derek J. Blake
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Fukutin-related protein (FKRP, MIM ID 606596) variants cause a range of muscular dystrophies associated with hypo-glycosylation of the matrix receptor, α-dystroglycan. These disorders are almost exclusively caused by homozygous or compound heterozyg
Externí odkaz:
https://doaj.org/article/35da4e2141714c0fa0e8671065cea821
Autor:
Emily A. Bates, James A. Davies, Jana Váňová, Davor Nestić, Valerie S. Meniel, Sarah Koushyar, Tabitha G. Cunliffe, Rosie M. Mundy, Elise Moses, Hanni K. Uusi-Kerttula, Alexander T. Baker, David K. Cole, Dragomira Majhen, Pierre J. Rizkallah, Toby Phesse, John D. Chester, Alan L. Parker
Publikováno v:
Molecular Therapy: Oncolytics, Vol 25, Iss , Pp 43-56 (2022)
Oncolytic virotherapies (OV) hold immense clinical potential. OV based on human adenoviruses (HAdV) derived from HAdV with naturally low rates of pre-existing immunity will be beneficial for future clinical translation. We generated a low-seroprevale
Externí odkaz:
https://doaj.org/article/e338981455f0434ea7eb7c74250e7338
Autor:
Rory M. Crean, Bruce J. MacLachlan, Florian Madura, Thomas Whalley, Pierre J. Rizkallah, Christopher J. Holland, Catriona McMurran, Stephen Harper, Andrew Godkin, Andrew K. Sewell, Christopher R. Pudney, Marc W. van der Kamp, David K. Cole
Publikováno v:
Molecular Therapy: Oncolytics, Vol 18, Iss , Pp 443-456 (2020)
Immuno-oncology approaches that utilize T cell receptors (TCRs) are becoming highly attractive because of their potential to target virtually all cellular proteins, including cancer-specific epitopes, via the recognition of peptide-human leukocyte an
Externí odkaz:
https://doaj.org/article/468343d29a914222a4306cde545a8b9d
Autor:
Nehad Noby, Husam Sabah Auhim, Samuel Winter, Harley L. Worthy, Amira M. Embaby, Hesham Saeed, Ahmed Hussein, Christopher R. Pudney, Pierre J. Rizkallah, Stephen A. Wells, D. Dafydd Jones
Publikováno v:
Open Biology, Vol 11, Iss 12 (2021)
Here we determined the structure of a cold active family IV esterase (EstN7) cloned from Bacillus cohnii strain N1. EstN7 is a dimer with a classical α/β hydrolase fold. It has an acidic surface that is thought to play a role in cold-adaption by re
Externí odkaz:
https://doaj.org/article/742a9bfe43b248879d57a96a80adc331
Autor:
Hannah L. Best, Lainey J. Williamson, Magdalena Lipka-Lloyd, Helen Waller-Evans, Emyr Lloyd-Evans, Pierre J. Rizkallah, Colin Berry
Publikováno v:
Toxins, Vol 14, Iss 12, p 863 (2022)
Tpp80Aa1 from Bacillus thuringiensis is a Toxin_10 family protein (Tpp) with reported action against Culex mosquitoes. Here, we demonstrate an expanded target range, showing Tpp80Aa1 is also active against the larvae of Anopheles gambiae and Aedes ae
Externí odkaz:
https://doaj.org/article/464c13bcf6e14c4481bcdbf83c7d7ac0
Autor:
Alexander T. Baker, Alexander Greenshields-Watson, Lynda Coughlan, James A. Davies, Hanni Uusi-Kerttula, David K. Cole, Pierre J. Rizkallah, Alan L. Parker
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Adenovirus based (AdV) vectors are promising platforms for therapeutics and vaccines, but receptor usage of serotypes in clinical development remains unclear. Here, based on crystal structures and modeling, Baker et al. show that HAdV-D26/48 fiber kn
Externí odkaz:
https://doaj.org/article/f0b1e1b1b41e4d7397fac97ab6273893
Autor:
Jacob R. Pope, Rachel L. Johnson, W. David Jamieson, Harley L. Worthy, Senthilkumar Kailasam, Rochelle D. Ahmed, Ismail Taban, Husam Sabah Auhim, Daniel W. Watkins, Pierre J. Rizkallah, Oliver K. Castell, D. Dafydd Jones
Publikováno v:
Advanced Science, Vol 8, Iss 1, Pp n/a-n/a (2021)
Abstract Fluorescent proteins (FPs) are commonly used in pairs to monitor dynamic biomolecular events through changes in proximity via distance dependent processes such as Förster resonance energy transfer (FRET). The impact of FP association is ass
Externí odkaz:
https://doaj.org/article/7938b9fd96124ed0a636bbaf8e40a461
Autor:
Alexander Greenshields-Watson, Meriem Attaf, Bruce J. MacLachlan, Thomas Whalley, Cristina Rius, Aaron Wall, Angharad Lloyd, Hywel Hughes, Kathryn E. Strange, Georgina H. Mason, Andrea J. Schauenburg, Sarah L. Hulin-Curtis, James Geary, Yuan Chen, Sarah N. Lauder, Kathryn Smart, Dhanasekaran Vijaykrishna, Miguel L. Grau, Mikhail Shugay, Robert Andrews, Garry Dolton, Pierre J. Rizkallah, Awen M. Gallimore, Andrew K. Sewell, Andrew J. Godkin, David K. Cole
Publikováno v:
Cell Reports, Vol 32, Iss 2, Pp 107885- (2020)
Summary: T cell recognition of peptides presented by human leukocyte antigens (HLAs) is mediated by the highly variable T cell receptor (TCR). Despite this built-in TCR variability, individuals can mount immune responses against viral epitopes by usi
Externí odkaz:
https://doaj.org/article/ac1881b0cc804226bb104e9cab830657
Autor:
Colin D. Reynolds, Lisa M. Wright, Pierre J. Rizkallah, Anthony K. Allen, Willy J. Peumans, Els Van Damme, Michael J. Donovan
Publikováno v:
Protein & Peptide Letters. 6:253-258
Abstract: In the last decade a number of single-domain mannose-binding lectins (11-14 kDa) have l:ieen characterised from different monocot plants and shown to belong to a superfamily of evolutionary related proteins. We have isolated and crystallize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0c650b1ab175cc116ca36ed229922fc
https://doi.org/10.2174/092986650604221115162014
https://doi.org/10.2174/092986650604221115162014
Autor:
Harley L. Worthy, Lainey J. Williamson, Husam Sabah Auhim, Stephen H. Leppla, Inka Sastalla, D. Dafydd Jones, Pierre J. Rizkallah, Colin Berry
Publikováno v:
Toxins, Vol 13, Iss 4, p 253 (2021)
The Hbl toxin is a three-component haemolytic complex produced by Bacillus cereus sensu lato strains and implicated as a cause of diarrhoea in B. cereus food poisoning. While the structure of the HblB component of this toxin is known, the structures
Externí odkaz:
https://doaj.org/article/b0dc8e12acd44a729c284ab42d0a7198