Zobrazeno 1 - 10
of 197
pro vyhledávání: '"J. Ravi Prakash"'
Heterogeneous interactions and polymer entropy decide organization and dynamics of chromatin domains
Publikováno v:
Biophysical Journal. 121:2794-2812
Chromatin is known to be organized into multiple domains of varying sizes and compaction. While these domains are often imagined as static structures, they are highly dynamic and show cell-to-cell variability. Since processes such as gene regulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6928e2a3235ab8fc021aa054a87ebe5
https://doi.org/10.1016/j.bpj.2022.06.008
https://doi.org/10.1016/j.bpj.2022.06.008
Publikováno v:
Physical Review Research, Vol 2, Iss 1, p 013331 (2020)
The existence of two types of internal friction—wet and dry—is revisited, and a simple protocol is proposed for distinguishing between the two types and extracting the appropriate internal friction coefficient. The scheme requires repeatedly stre
Externí odkaz:
https://doaj.org/article/656d640318814771afa8e7a6a9520c08
Although the non-equilibrium behaviour of polymer solutions is generally well understood, particularly in extensional flow, there remain several unanswered questions for dilute solutions in simple shear flow, and full quantitative agreement with expe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abb6094e5818b8c45e119f7bde6e8cf8
Publikováno v:
Korea-Australia Rheology Journal. 31:255-266
The extensional rheology of polymeric liquids has been extensively examined through experiments and theoretical predictions. However, a systematic study of the extensional rheology of polymer solutions in the semidilute regime, in terms of examining
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6f5c90b5399427c116d67d1f2263fbe
https://doi.org/10.1007/s13367-019-0026-1
https://doi.org/10.1007/s13367-019-0026-1
Heterogeneous interactions and polymer entropy decide organization and dynamics of chromatin domains
Chromatin is known to be organized into multiple domains of varying sizes and compaction. While these domains are often imagined as static structures, they are highly dynamic and show cell-to-cell variability. Since processes such as gene regulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82d6b6a4c9356f141d64232fdef8c53e
https://doi.org/10.1101/2021.02.17.431616
https://doi.org/10.1101/2021.02.17.431616
A coarse-grained bead-spring-dashpot chain model with the dashpots representing the presence of internal friction, is solved exactly numerically, for the case of chains with more than two beads. Using a decoupling procedure to remove the explicit cou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42de692ab36b43481c9b79d04ca2d08d
The Rouse model with internal friction (RIF), a widely used theoretical framework to interpret the effects of internal friction on conformational transitions in biomolecules, is shown to be an approximate treatment that is based on preaveraging inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1fc005eace1d5f5a88075b59dae9cb4
Publikováno v:
Human & Experimental Toxicology. 37:540-556
Background:Nicotine and cigarette smoking (CS) are associated with addiction behavior, drug-seeking, and abuse. However, the mechanisms that mediate this association especially, the role of brain-derived neurotrophic factor (BDNF), dopamine (DA), and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::320cd24dc2321f478e4dce8ecd9e0177
https://doi.org/10.1177/0960327117698543
https://doi.org/10.1177/0960327117698543
Rigid macromolecules or polymer chains with persistence length on the order of the contour length (or greater) have traditionally been modelled as rods or very stiff springs. The FENE-Fraenkel-spring dumbbell, which is finitely extensible about a non
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7d8b6f985dc237fd25fc13e97cafc9f
Publikováno v:
Biophysical Journal
Biophys J
Biophys J
The three-dimensional organization of chromatin, on the length scale of a few genes, is crucial in determining the functional state - accessibility and the amount of gene expression - of the chromatin. Recent advances in chromosome conformation captu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69568513db9798ee47a1693e427f9df3