Zobrazeno 1 - 10
of 71
pro vyhledávání: '"J. Rasko"'
Autor:
Gerard J. Chu, Charles G. Bailey, Rajini Nagarajah, Sharon M. Sagnella, Stephen Adelstein, John E. J. Rasko
Publikováno v:
Cancer Cell International, Vol 23, Iss 1, Pp 1-18 (2023)
Abstract Background Chimeric antigen receptor (CAR) T-cells have revolutionized the treatment of CD19- and B-cell maturation antigen-positive haematological malignancies. However, the effect of a CAR construct on the function of T-cells stimulated vi
Externí odkaz:
https://doaj.org/article/c567b9f811a84470a0eab063b6a318d5
Autor:
Jaynish S. Shah, Michael J. G. Milevskiy, Veronika Petrova, Amy Y. M. Au, Justin J. L. Wong, Jane E. Visvader, Ulf Schmitz, John E. J. Rasko
Publikováno v:
Breast Cancer Research, Vol 24, Iss 1, Pp 1-11 (2022)
Abstract Background After many years of neglect in the field of alternative splicing, the importance of intron retention (IR) in cancer has come into focus following landmark discoveries of aberrant IR patterns in cancer. Many solid and liquid tumour
Externí odkaz:
https://doaj.org/article/683ffd8de71f4bcaa4fcd67ff3102fbf
Autor:
Dannel Yeo, Steven Kao, Ruta Gupta, Sara Wahlroos, Althea Bastian, Heidi Strauss, Vera Klemm, Prajwol Shrestha, Arturo B. Ramirez, Lillian Costandy, Ryan Huston, Brady S. Gardner, Peter Grimison, Jonathan R. Clark, John E. J. Rasko
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionThe reliable and accurate detection of rare circulating tumor cells (CTCs) from cancer patient blood samples promises advantages in both research and clinical applications. Numerous CTC detection methods have been explored that rely on ei
Externí odkaz:
https://doaj.org/article/209896470a35482d853d2b38153637b2
Publikováno v:
Biomarker Research, Vol 9, Iss 1, Pp 1-13 (2021)
Abstract Malignant mesothelioma (MM) is a treatment-resistant tumor originating in the mesothelial lining of the pleura or the abdominal cavity with very limited treatment options. More effective therapeutic approaches are urgently needed to improve
Externí odkaz:
https://doaj.org/article/d5dfe9e6c3464aae92c833a163be5fef
Autor:
Gabrielle M. O’Sullivan, Joshua G. Philips, Heidi J. Mitchell, Michael Dornbusch, John E. J. Rasko
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
•In contrast to the prior voluntary system, since 2001, gene technology in Australia has been regulated under a legislated national Gene Technology Regulatory Scheme which is administered by the Gene Technology Regulator.•The Scheme provides scie
Externí odkaz:
https://doaj.org/article/42199189d83c4b49a2b76926e2613b44
Autor:
Valerie Barbier, Johanna Erbani, Corrine Fiveash, Julie M. Davies, Joshua Tay, Michael R. Tallack, Jessica Lowe, John L. Magnani, Diwakar R. Pattabiraman, Andrew C. Perkins, Jessica Lisle, John E. J. Rasko, Jean-Pierre Levesque, Ingrid G. Winkler
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The cell adhesion molecule E-selectin regulates haematopoietic stem cell self-renewal in the bone marrow vascular niche. Here, the authors show E-selectin adhesion directly induces survival signaling in acute myeloid leukaemia and therapeutic inhibit
Externí odkaz:
https://doaj.org/article/7dde84bbf79f4a748ecf6d1fab0d7161
Autor:
Kilian Kelly, John E. J. Rasko
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Graft versus host disease (GvHD) is a life-threating complication of allogeneic hematopoietic stem cell transplantation, which is initially treated with high dose corticosteroids. Approximately 50% of acute GvHD cases are resistant to steroid treatme
Externí odkaz:
https://doaj.org/article/7599878c19094f2f83020d633338b199
Autor:
Tamara Treleaven, Matthew Zada, Rajini Nagarajah, Charles G. Bailey, John E. J. Rasko, Michael B. Morris, Margot L. Day
Publikováno v:
Cells, Vol 12, Iss 1, p 18 (2022)
L-proline (Pro) has previously been shown to support normal development of mouse embryos. Recently we have shown that Pro improves subsequent embryo development when added to fertilisation medium during in vitro fertilisation of mouse oocytes. The me
Externí odkaz:
https://doaj.org/article/5d18cc2b9ed44b3ea03a67edc9551eda
Publikováno v:
Cell Communication and Signaling, Vol 17, Iss 1, Pp 1-11 (2019)
Abstract Background Growth factors, such as EGF, activate the PI3K/Akt/mTORC1 signalling pathway, which regulates a distinct program of protein synthesis leading to cell growth. This pathway relies on mTORC1 sensing sufficient levels of intracellular
Externí odkaz:
https://doaj.org/article/434dc0c6851742df8f7324f72d6605f2
Autor:
Megha Rajasekhar, Ulf Schmitz, Stephane Flamant, Justin J.-L. Wong, Charles G. Bailey, William Ritchie, Jeff Holst, John E. J. Rasko
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Abstract Myelopoiesis involves differentiation of hematopoietic stem cells to cellular populations that are restricted in their self-renewal capacity, beginning with the common myeloid progenitor (CMP) and leading to mature cells including monocytes
Externí odkaz:
https://doaj.org/article/5130f8e3f39c40e099172e258a4f2129