Zobrazeno 1 - 10
of 73
pro vyhledávání: '"J. Ramsoondar"'
Publikováno v:
Immunogenetics. 64:469-473
Six putative subclasses of expressed porcine IgG have been described from gene sequences and allotypic variants for five of these have been proposed. We tested this hypothesis by studying the transcription of these 11 variants in outbred hemizygous f
Autor:
A. Vance, Todd Vaught, Jeff A. Monahan, Irina A. Polejaeva, Peter M. Jobst, Y. Dai, Jeremy Boone, M. Mendicino, Carol Phelps, Kevin D. Wells, David Ayares, LeRoith T, J. Ramsoondar, Xiu-Zhu Sun, Dandro A, Suyapa Ball, John E. Butler, Nancy Wertz, Bergman Z, S. Chen
Publikováno v:
Transgenic Research
A poly(A)-trap gene targeting strategy was used to disrupt the single functional heavy chain (HC) joining region (J(H)) of swine in primary fibroblasts. Genetically modified piglets were then generated via somatic cell nuclear transfer (SCNT) and bre
Autor:
Grimus, Sarah1,2,3, Sarangova, Victoria4, Welzel, Petra B.4, Ludwig, Barbara5,6,7,8, Seissler, Jochen9, Kemter, Elisabeth1,2,3,7, Wolf, Eckhard1,2,3,7 ewolf@genzentrum.lmu.de, Ali, Asghar1,2,3
Publikováno v:
Advanced Science. 8/21/2024, Vol. 11 Issue 31, p1-27. 27p.
Autor:
Kenneth R. Bondioli, Barry L. Williams, Cristina Costa, Jagdeece J. Ramsoondar, Zoltan Machaty, William L. Fodor
Publikováno v:
Biology of Reproduction. 69:437-445
The production of genetically engineered pigs as xenotransplant donors aims to solve the severe shortage of organs for transplantation in humans. The first barrier to successful xenotransplantation is hyperacute rejection (HAR). HAR is a rapid and ma
Publikováno v:
Biology of Reproduction. 67:1133-1139
The presence of the Na+/Ca2+ exchange mechanism was investigated in porcine oocytes. Immature and in vitro-matured oocytes were loaded with the Ca2+-sensitive fluorescent dye fura 2 and changes in the intracellular free Ca2+ concentration ([Ca2+]i) w
Autor:
Zoltán Macháty, Jagdeece J. Ramsoondar, Aaron J. Bonk, Kenneth R. Bondioli, Randall S. Prather
Publikováno v:
Biology of Reproduction. 66:667-674
Mammalian oocytes are contacted with a compound that activates a trp calcium channel. In this manner activation or maturation of the oocyte can be achieved.
Autor:
Chang-Kyu Lee, Nannette Scales, Karen Moore, Jorge A. Piedrahita, Fuller W. Bazer, Troy L. Ott, Jagdeece J. Ramsoondar, Betty Oetama
Publikováno v:
Biology of Reproduction. 58:1321-1329
In mice, two pluripotent cell lines, embryonic stem (ES) cells and embryonic germ (EG) cells, have been identified. We present here results indicating that porcine EG cell lines can be isolated, genetically transformed, and utilized to make transgeni
Publikováno v:
Animal Genetics. 28:354-357
In the mouse, ciliary neurotrophic factor (CNTF) maintains embryonic stem cells in an undifferentiated state; yet, the heterologous protein has no similar effects on porcine embryonic stem (ES) cells. Consequently, we cloned and sequenced the porcine
Autor:
Peter M. Jobst, David Ayares, J. Ramsoondar, Suyapa Ball, Y. Dai, A. Vance, M. Mendicino, Nancy Wertz, Carol Phelps, Dandro A, Todd Vaught, Jeremy Boone, S. Chen, Kevin D. Wells, Jeff A. Monahan, John E. Butler, Irina A. Polejaeva
Publikováno v:
Transgenic research. 20(3)
Inactivation of the endogenous pig immunoglobulin (Ig) loci, and replacement with their human counterparts, would produce animals that could alleviate both the supply and specificity issues of therapeutic human polyclonal antibodies (PAbs). Platform
Autor:
John E. Butler, R. Dewald, Michael J. Welsh, Paul B. McCray, Igor Splichal, Joan K. Lunney, W.r. Brown, Marek Sinkora, J. Ramsoondar, Serge Muyldermans, Yiqiang Zhao, P. Navarro, Jishan Sun, Kelly M. Lager, Nancy Wertz, David L. Francis, F. Habe, C.s. Rogers, Imre Kacskovics, S. Dierks, F. Klobasa
Publikováno v:
Veterinary Immunology and Immunopathology
The ability to identify factors responsible for disease in all species depends on the ability to separate those factors which are environmental from those that are intrinsic. This is particularly important for studies on the development of the adapti