Zobrazeno 1 - 10
of 25
pro vyhledávání: '"J. R. Woodgett"'
Autor:
J. A. Hurcombe, P. Hartley, A. C. Lay, L. Ni, J. J. Bedford, J. P. Leader, S. Singh, A. Murphy, C. L. Scudamore, E. Marquez, A. F. Barrington, V. Pinto, M. Marchetti, L.-F. Wong, J. Uney, M. A. Saleem, P. W. Mathieson, S. Patel, R. J. Walker, J. R. Woodgett, S. E. Quaggin, G. I. Welsh, R. J. M. Coward
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Glycogen Synthase Kinase 3 (GSK3) has conserved functions across species but its role in the kidney is unclear. Here, the authors show that in the kidney podocyte cell of mice and related nephrocyte in Drosophila that GSK3 is a master regulator of fu
Externí odkaz:
https://doaj.org/article/051986d29ba44b0d9f2cf3bc9a46a0bb
Publikováno v:
The EMBO Journal. 15:4526-4536
The Drosophila gene product Wingless (Wg) is a secreted glycoprotein and a member of the Wnt gene family. Genetic analysis of Drosophila epidermal development has defined a putative paracrine Wg signalling pathway involving the zeste-white 3/shaggy (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d48b9fcca43f40d18f2d673d606ab2e4
https://doi.org/10.1002/j.1460-2075.1996.tb00830.x
https://doi.org/10.1002/j.1460-2075.1996.tb00830.x
Publikováno v:
Journal of Biological Chemistry. 267:16878-16882
In cells, stimulation of protein kinase C (PKC) results in the dephosphorylation of specific residues proximal to the DNA binding domain of c-Jun, a major component of the AP-1 transcription factor. Since phosphorylation of this region of c-Jun inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c792168f0937b2a4cac21aed649b6920
https://doi.org/10.1016/s0021-9258(18)41866-2
https://doi.org/10.1016/s0021-9258(18)41866-2
Cloning and Expression of Two Human p70 S6 Kinase Polypeptides Differing Only at Their Amino Termini
Autor:
J R, Grove, P, Banerjee, A, Balasubramanyam, P J, Coffer, D J, Price, J, Avruch, J R, Woodgett
Publikováno v:
Molecular and Cellular Biology. 11:5541-5550
Two classes of human cDNA encoding the insulin/mitogen-activated p70 S6 kinase have been isolated; the two classes differ only in the 5' region, such that the longer polypeptide (p70 S6 kinase alpha I; calculated Mr 58,946) consists of 525 amino acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ad3f7094197e5c86803e1238ccb74a1
https://doi.org/10.1128/mcb.11.11.5541-5550.1991
https://doi.org/10.1128/mcb.11.11.5541-5550.1991
Autor:
M P, Scheid, J R, Woodgett
Publikováno v:
Journal of mammary gland biology and neoplasia. 6(1)
Suppression of apoptosis is now recognized as a key contributory element to tumorigenesis in animal models and human cancer. The phosphatidylinositol 3' kinase pathway plays a seminal role in cell death suppression or "survival signaling." Over the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b3e895eb3cf33da17cf427d1cdd91bd3
https://pubmed.ncbi.nlm.nih.gov/11467455
https://pubmed.ncbi.nlm.nih.gov/11467455
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 163(6)
4-1BB is a member of the TNFR superfamily expressed on activated CD4+ and CD8+ T cells. 4-1BB can costimulate IL-2 production by resting primary T cells independently of CD28 ligation. In this study, we report signaling events following 4-1BB recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e1d99421d44773e701f20bf3b106a3d6
https://pubmed.ncbi.nlm.nih.gov/10477561
https://pubmed.ncbi.nlm.nih.gov/10477561
Publikováno v:
The Biochemical journal. 341
Transient expression of I2PP2A, a potent inhibitor of protein phosphatase 2A (PP2A), in HEK-293 cells increased the concentration and DNA binding of the proto-oncogene c-Jun. In contrast, expression of the catalytic subunit of PP2A (PP2AC) markedly d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5da68bee4e892cd7d7d484a633ea6d9c
https://pubmed.ncbi.nlm.nih.gov/10393085
https://pubmed.ncbi.nlm.nih.gov/10393085
Publikováno v:
The EMBO journal. 15(24)
Mixed lineage kinase-3 (MLK-3) is a 97 kDa serine/threonine kinase with multiple interaction domains, including a Cdc42 binding motif, but unknown function. Cdc42 and the related small GTP binding protein Rac1 can activate the SAPK/JNK and p38/RK str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bb65e0684fb391207e7adae59d772fce
https://pubmed.ncbi.nlm.nih.gov/9003778
https://pubmed.ncbi.nlm.nih.gov/9003778
Autor:
F, Kiefer, L A, Tibbles, M, Anafi, A, Janssen, B W, Zanke, N, Lassam, T, Pawson, J R, Woodgett, N N, Iscove
Publikováno v:
The EMBO journal. 15(24)
In mammalian cells, a specific stress-activated protein kinase (SAPK/JNK) pathway is activated in response to inflammatory cytokines, injury from heat, chemotherapeutic drugs and UV or ionizing radiation. The mechanisms that link these stimuli to act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6cd48db244e5829092096d4d00379004
https://pubmed.ncbi.nlm.nih.gov/9003777
https://pubmed.ncbi.nlm.nih.gov/9003777
Publikováno v:
The EMBO journal. 15(1)
The B cell-associated surface molecule CD40 plays a key role in T cell-dependent B cell maturation, as individuals with defects in either CD40 or its ligand are impaired in immunoglobulin isotype class switching and germinal center formation. CD40 si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::905f2c98dc75d72cdab1f362600d0b3b
https://pubmed.ncbi.nlm.nih.gov/8598210
https://pubmed.ncbi.nlm.nih.gov/8598210