Zobrazeno 1 - 8
of 8
pro vyhledávání: '"J. R. Woodburn"'
Autor:
Jeffrey J Barlow, Lynn Scarlett, Keith Hopkinson Gibson, Susan Ashton, Walter Grundy, Lianne Henthorn, Laura Richards, Brenda Curry, Mark P Healy, Barker Andrew John, J. R. Woodburn, Godfrey Andrew Aydon
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:1911-1914
This paper describes the development of the epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 from a lead series of 4-anilinoquinazoline compounds. ZD1839 has suitable properties for use as a clinically effective drug and shows activi
Autor:
L. Scarlett, Walter Grundy, Barker Andrew John, Keith Hopkinson Gibson, J. R. Woodburn, Susan Ashton, Godfrey Andrew Aydon, D. S. Brown, Brenda Curry
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2723-2728
Investigation of structure-activity relationships of novel quinazolines has identified a 4-(4-iso-quinolylamino)-quinazoline and a 4-(trans-2-phenylcyclopropylamino)-quinazoline as potent inhibitors of EGF-receptor tyrosine kinase in vitro. Further m
Autor:
D. H. Davies, L. R. Green, D. S. Brown, J. R. Woodburn, A. J. Barker, S. A. Cartlidge, A. E. Wakeling
Publikováno v:
Endocrine Related Cancer. 4:351-355
Autor:
D. H. Davies, L. R. Green, D. S. Brown, J. R. Woodburn, A. J. Barker, A. E. Wakeling, S. A. Cartlidge
Publikováno v:
Breast Cancer Research and Treatment. 38:67-73
Since the mitogenic action of EGF is mediated by ligand-induced autophosphorylation of the EGF receptor (EGFR), and EGFR is commonly overexpressed in solid human tumours, inhibitors of receptor tyrosine kinase activity (RTK) could prove to be effecti
Autor:
Godfrey Andrew Aydon, Susan Ashton, J. R. Woodburn, Walter Grundy, L. Scarlett, Barker Andrew John, Brenda Curry, Keith Hopkinson Gibson, D. S. Brown
Publikováno v:
ChemInform. 29
Publikováno v:
Steroids. 65(10-11)
From the dual progestin/antiandrogenic properties of certain synthetic steroids (e.g. cyproterone acetate), it was apparent that the progesterone (P) and androgen (A) receptors must have some common ligand binding features. The nonsteroidal antiandro
Autor:
Barker Andrew John, Keith Hopkinson Gibson, A. E. Wakeling, L. Scarlett, Susan Ashton, L. R. Henthorn, Brenda Curry, J. R. Woodburn
Publikováno v:
Journal of Immunotherapy. 20:408
Autor:
J. R. Woodburn, B. J. A. Furr
Publikováno v:
Journal of endocrinological investigation. 11(7)